Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses

Power of Biocatalysis for Organic Synthesis

(2021) Christoph K. Winkler et al.   ACS Central Science

Chemoenzymatic Total Synthesis of Natural Products

(2021) Suman Chakrabarty et al.   ACCOUNTS OF CHEMICAL RESEARCH

Powering Artificial Enzymatic Cascades with Electrical Energy

(2020) Ammar Al‐Shameri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transaminases for industrial biocatalysis: novel enzyme discovery

(2020) Stephen A. Kelly et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases

(2020) Yu-Hui Zhang et al.   ORGANIC LETTERS

The Development of Biocatalysis as a Tool for Drug Discovery

(2020) Jenny Schwarz et al.   CHIMIA

Biocatalytic Monoacylation of Symmetrical Diamines and its Application to the Synthesis of Pharmaceutically Relevant Amides

(2020) Max Lubberink et al.   ACS Catalysis

The high cost of prescription drugs: causes and solutions

(2020) S. Vincent Rajkumar   Blood Cancer Journal

Modular Enzymatic Cascade Synthesis of Nucleotides Using a (d)ATP Regeneration System

(2020) Maryke Fehlau et al.   Frontiers in Bioengineering and Biotechnology

Photobiocatalytic cascades: combining chemical and enzymatic transformations fueled by light

(2020) Fatma Feyza Özgen et al.   CHEMBIOCHEM

Cascade Biocatalysis for Regio- and Stereoselective Aminohydroxylation of Styrenyl Olefins to Enantiopure Arylglycinols

(2020) Jiandong Zhang et al.   ACS Sustainable Chemistry & Engineering

Photo-Biocatalysis: Biotransformations in the Presence of Light

(2019) Luca Schmermund et al.   ACS Catalysis

Green chemistry in United States science policy

(2019) Emily A. A. Jarvis   Green Chemistry Letters and Reviews

Synthesis of Ribavirin, Tecadenoson, and Cladribine by Enzymatic Transglycosylation

(2019) Marco Rabuffetti et al.   Catalysts

One Pot Asymmetric Synthesis of ( R )‐Phenylglycinol from Racemic Styrene Oxide via Cascade Biocatalysis

(2019) Zai‐Bao Sun et al.   ChemCatChem

One-pot Two-Step Chemoenzymatic Cascade for the Synthesis of a Bis-benzofuran Derivative

(2019) M.A. Stephanie Mertens et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis

(2019) Carol J. Hartley et al.   Nature Catalysis

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

(2019) Markus Schober et al.   Nature Catalysis

Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases

(2019) Rhys Cutlan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemoenzymatic o-Quinone Methide Formation

(2019) Tyler J. Doyon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Machine Learning in Enzyme Engineering

(2019) Stanislav Mazurenko et al.   ACS Catalysis

Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

(2018) Huihua Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Speeding up enzyme discovery and engineering with ultrahigh-throughput methods

(2018) Hans Adrian Bunzel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Total synthesis of pipecolic acid and 1-C-alkyl 1,5-iminopentitol derivatives by way of stereoselective aldol reactions from (S)-isoserinal

(2018) Sebastian Baś et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Combinatorial drug discovery in nanoliter droplets

(2018) Anthony Kulesa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase

(2018) William R. Birmingham et al.   ACS Catalysis

Industrial Applications of Enzymes: Recent Advances, Techniques, and Outlooks

(2018) Jordan Chapman et al.   Catalysts

Extending Designed Linear Biocatalytic Cascades for Organic Synthesis

(2018) Somayyeh Gandomkar et al.   ChemCatChem

Biocatalytic production of amino-carbohydrates through oxidoreductase and transaminase cascades

(2018) Ville Aumala et al.   ChemSusChem

Photocatalytic Synthesis of Pipecolic Acid from Lysine on TiO2: Effects of the Structure of Catalysts and Adsorbed Species on Chiral Selectivity

(2018) Yuxin Zhai et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Transaminase biocatalysis: optimization and application

(2017) Fei Guo et al.   GREEN CHEMISTRY

Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation

(2017) Torsten Sehl et al.   GREEN CHEMISTRY

Biocatalysis in the Pharmaceutical Industry: The Need for Speed

(2017) Matthew D. Truppo   ACS Medicinal Chemistry Letters

Toward Rational Design of High-efficiency Enzyme Cascades

(2017) Yifei Zhang et al.   ACS Catalysis

Enantioselective Synthesis of 1-Aryl-Substituted Tetrahydroisoquinolines Employing Imine Reductase

(2017) Jinmei Zhu et al.   ACS Catalysis

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

(2017) Iustina Slabu et al.   ACS Catalysis

Cofactor NAD(P)H Regeneration Inspired by Heterogeneous Pathways

(2017) Xiaodong Wang et al.   Chem

Co-immobilized Phosphorylated Cofactors and Enzymes as Self-Sufficient Heterogeneous Biocatalysts for Chemical Processes

(2016) Susana Velasco-Lozano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of NAD(P)H oxidase for cofactor regeneration in dehydrogenase catalyzed oxidations

(2016) Gustav Rehn et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Artificial concurrent catalytic processes involving enzymes

(2015) Valentin Köhler et al.   CHEMICAL COMMUNICATIONS

InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

(2015) Gideon Grogan et al.   CHEMISTRY-A EUROPEAN JOURNAL

A system for ω-transaminase mediated (R)-amination using l-alanine as an amine donor

(2015) N. Richter et al.   GREEN CHEMISTRY

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

(2015) B. R. Lichman et al.   GREEN CHEMISTRY

Towards a sustainable system of drug development

(2014) Ellen H.M. Moors et al.   DRUG DISCOVERY TODAY

Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers

(2014) Torsten Sehl et al.   GREEN CHEMISTRY

Bioretrosynthetic construction of a didanosine biosynthetic pathway

(2014) William R Birmingham et al.   Nature Chemical Biology

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

(2013) Katharina Tauber et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols

(2012) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flavoenzymes: Versatile catalysts in biosynthetic pathways

(2012) Christopher T. Walsh et al.   NATURAL PRODUCT REPORTS

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

Purification and Characterization of a Novel (R)-Imine Reductase fromStreptomycessp. GF3587

(2011) Koichi MITSUKURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

S-Selective Mixed Carboligation by Structure-Based Design of the Pyruvate Decarboxylase from Acetobacter pasteurianus

(2011) Dörte Rother neé Gocke et al.   ChemCatChem

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid screening and scale-up of transaminase catalysed reactions

(2008) Matthew D. Truppo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

(2008) Carlos A. Martinez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT