Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

Synthesis of chiral amines using redox biocatalysis

(2018) Gideon Grogan   CURRENT OPINION IN CHEMICAL BIOLOGY

Enantioselective reduction of sulfur-containing cyclic imines through biocatalysis

(2018) Nadine Zumbrägel et al.   Nature Communications

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

(2017) P. Matzel et al.   GREEN CHEMISTRY

Asymmetric Biocatalytic Reduction of Cyclic Imines: Design and Application of a Tailor-Made Whole-Cell Catalyst

(2017) Harald Gröger et al.   HETEROCYCLES

A reductive aminase from Aspergillus oryzae

(2017) Godwin A. Aleku et al.   Nature Chemistry

Recent advances in imine reductase-catalyzed reactions

(2017) Maike Lenz et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Updating and further expanding GSK's solvent sustainability guide

(2016) Catherine M. Alder et al.   GREEN CHEMISTRY

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

(2016) Godwin A. Aleku et al.   ACS Catalysis

Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis

(2015) Hao Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalytic Imine Reduction and Reductive Amination of Ketones

(2015) Joerg H. Schrittwieser et al.   ADVANCED SYNTHESIS & CATALYSIS

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

(2015) Dennis Wetzl et al.   CHEMBIOCHEM

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

(2015) F. G. Mutti et al.   SCIENCE

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

(2012) Michael J. Abrahamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

(2011) Concepcion Jimenez-Gonzalez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE