Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy

Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect

(2021) Chao Wang et al.   JOURNAL OF CONTROLLED RELEASE

Manganese salts function as potent adjuvants

(2021) Rui Zhang et al.   Cellular & Molecular Immunology

2D Piezoelectric Bi 2 MoO 6 Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

(2021) Yushan Dong et al.   ADVANCED MATERIALS

Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy

(2021) Xiaoqi Sun et al.   Nature Nanotechnology

Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy

(2020) Leilei Shi et al.   ACS Nano

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

(2020) John D. Martin et al.   Nature Reviews Clinical Oncology

T Cell Dysfunction and Exhaustion in Cancer

(2020) Zhen Zhang et al.   Frontiers in Cell and Developmental Biology

Dendritic Cells and Their Role in Immunotherapy

(2020) Alycia Gardner et al.   Frontiers in Immunology

Immunoadjuvants for Cancer Immunotherapy: A Review of Recent Developments

(2020) Asmita Banstola et al.   Acta Biomaterialia

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

(2020) Zhen Zhao et al.   Cell Reports

Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

(2020) Yuefei Zhu et al.   Acta Pharmaceutica Sinica B

A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

(2019) Zhigang Ren et al.   ADVANCED MATERIALS

In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence

(2019) Xiao Han et al.   BIOMATERIALS

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Dendritic Cells and Programmed Death-1 Blockade: A Joint Venture to Combat Cancer

(2018) Maarten Versteven et al.   Frontiers in Immunology

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Micro/Nanoparticle-Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

(2016) Xiaoqin Qian et al.   ADVANCED MATERIALS

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor

(2016) Yekuo Li et al.   Scientific Reports

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Dendritic Cells in the Cancer Microenvironment

(2013) Yang Ma et al.   Journal of Cancer

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology