Targeting the endocannabinoid system in the treatment of PTSD: A promising case of preclinical-clinical translation?

Endocannabinoid reactivity to acute stress: Investigation of the relationship between salivary and plasma levels

(2021) Luke Ney et al.   BIOLOGICAL PSYCHOLOGY

Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals

(2021) Duncan G.J. Green et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory

(2021) Ikumi Mizuno et al.   Pharmacological Reports

The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial

(2021) Marcel O. Bonn-Miller et al.   PLoS One

Fear extinction learning and anandamide: an fMRI study in healthy humans

(2021) Jennifer Spohrs et al.   Translational Psychiatry

A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults

(2021) Nicole L. Zabik et al.   JOURNAL OF NEUROSCIENCE RESEARCH

2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics

(2020) Gaurav Bedse et al.   BIOLOGICAL PSYCHIATRY

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

(2020) Elliot D. Mock et al.   Nature Chemical Biology

Cannabinoid CB2 receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear

(2020) Devon Ivy et al.   NEUROPSYCHOPHARMACOLOGY

Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: a preliminary study

(2020) Christine A. Rabinak et al.   PSYCHOPHARMACOLOGY

Influence of Δ9-tetrahydrocannabinol on long-term neural correlates of threat extinction memory retention in humans

(2019) Mira Z. Hammoud et al.   NEUROPSYCHOPHARMACOLOGY

Loss of exercise- and stress-induced increases in circulating 2-arachidonoylglycerol concentrations in adults with chronic PTSD

(2019) Kevin M. Crombie et al.   BIOLOGICAL PSYCHOLOGY

Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial

(2019) Leah M. Mayo et al.   BIOLOGICAL PSYCHIATRY

Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala

(2019) Farhana Yasmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex

(2018) Jayme R. McReynolds et al.   BIOLOGICAL PSYCHIATRY

Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation

(2018) Patrizia Ratano et al.   NEUROPHARMACOLOGY

Modulation of the endocannabinoid system by sex hormones: Implications for Posttraumatic Stress Disorder

(2018) Luke John Ney et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Functional Neuroanatomy of Emotion and Its Regulation in PTSD

(2018) Jacklynn M. Fitzgerald et al.   HARVARD REVIEW OF PSYCHIATRY

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

(2018) Gaurav Bedse et al.   Translational Psychiatry

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice

(2018) Leah M. Mayo et al.   MOLECULAR PSYCHIATRY

Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice

(2018) Victoria S. Cavener et al.   Frontiers in Neuroscience

Effects of acute Δ9-tetrahydrocannabinol on next-day extinction recall is mediated by post-extinction resting-state brain dynamics

(2018) Christine A. Rabinak et al.   NEUROPHARMACOLOGY

Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses

(2018) Tina Zimmermann et al.   NEUROPSYCHOPHARMACOLOGY

Reconsolidation/destabilization, extinction and forgetting of fear memory as therapeutic targets for PTSD

(2018) Satoshi Kida   PSYCHOPHARMACOLOGY

Endocannabinoid interactions in the regulation of acquisition of contextual conditioned fear

(2018) Zoltan Balogh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The involvement of cannabinoids and mTOR in the reconsolidation of an emotional memory in the hippocampal–amygdala–insular circuit

(2017) Salman Zubedat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle

(2017) Daniel E. Heinz et al.   NEUROPHARMACOLOGY

Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats

(2017) Maria Morena et al.   NEUROPSYCHOPHARMACOLOGY

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

(2017) Matthew N Hill et al.   NEUROPSYCHOPHARMACOLOGY

Pretreatment biomarkers predicting PTSD psychotherapy outcomes: A systematic review

(2017) Peter J. Colvonen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

(2017) Annelot C. M. van Esbroeck et al.   SCIENCE

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

(2017) Rebecca J. Bluett et al.   Nature Communications

FAAHGene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence

(2016) Primavera A. Spagnolo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions

(2016) Catherine H. Demers et al.   BIOLOGICAL PSYCHIATRY

Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels

(2016) Imke Jenniches et al.   BIOLOGICAL PSYCHIATRY

EFFECTIVENESS OF INTERNET-DELIVERED COGNITIVE BEHAVIORAL THERAPY FOR POSTTRAUMATIC STRESS DISORDER: A SYSTEMATIC REVIEW AND META-ANALYSIS

(2016) Marit Sijbrandij et al.   DEPRESSION AND ANXIETY

Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma

(2016) Judit Lazary et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala

(2016) S. Di et al.   JOURNAL OF NEUROSCIENCE

Involvement of the infralimbic cortex and CA1 hippocampal area in reconsolidation of a contextual fear memory through CB1 receptors: Effects of CP55,940

(2016) Fabiana Santana et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety

(2016) Maria Morena et al.   NEUROPHARMACOLOGY

Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species

(2016) Dylan G. Gee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid concentrations in hair are associated with PTSD symptom severity

(2016) Sarah Wilker et al.   PSYCHONEUROENDOCRINOLOGY

Lessons from the fatal French study BIA-10-2474

(2016) Nicholas Moore   BMJ-British Medical Journal

Lessons from the fatal French study BIA-10-2474

(2016) Nicholas Moore   BMJ-British Medical Journal

2-arachidonoylglycerol signaling impairs short-term fear extinction

(2016) N D Hartley et al.   Translational Psychiatry

Neural changes in extinction recall following prolonged exposure treatment for PTSD: A longitudinal fMRI study

(2016) Liat Helpman et al.   NeuroImage-Clinical

Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats

(2015) Jonathan J. Simone et al.   BEHAVIOURAL BRAIN RESEARCH

The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB

(2015) Isabelle Boileau et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Corticotropin-Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety

(2015) J. M. Gray et al.   JOURNAL OF NEUROSCIENCE

The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction

(2015) R. M. Sachser et al.   LEARNING & MEMORY

Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats

(2015) James Lim et al.   NEUROPSYCHOPHARMACOLOGY

Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids

(2015) Ozge Gunduz-Cinar et al.   NEUROPSYCHOPHARMACOLOGY

Neurobiological Interactions Between Stress and the Endocannabinoid System

(2015) Maria Morena et al.   NEUROPSYCHOPHARMACOLOGY

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

(2015) Alvaro Llorente-Berzal et al.   PSYCHOPHARMACOLOGY

Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

(2015) John M. Keith et al.   ACS Medicinal Chemistry Letters

FAAH genetic variation enhances fronto-amygdala function in mouse and human

(2015) Iva Dincheva et al.   Nature Communications

Prefrontal inputs to the amygdala instruct fear extinction memory formation

(2015) O. Bukalo et al.   Science Advances

The endocannabinoid system: An emotional buffer in the modulation of memory function

(2014) Maria Morena et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training

(2014) Maria Morena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice

(2014) Mano Aliczki et al.   PSYCHOPHARMACOLOGY

Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice

(2013) Mano Aliczki et al.   HORMONES AND BEHAVIOR

Cannabinoid modulation of prefrontal–limbic activation during fear extinction learning and recall in humans

(2013) Christine A. Rabinak et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks

(2013) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Testing the effects of Δ9-THC and D-cycloserine on extinction of conditioned fear in humans

(2012) Floris Klumpers et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

(2012) O Gunduz-Cinar et al.   MOLECULAR PSYCHIATRY

Cannabinoid receptors activation and glucocorticoid receptors deactivation in the amygdala prevent the stress-induced enhancement of a negative learning experience

(2012) Assaf Ramot et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cannabinoid facilitation of fear extinction memory recall in humans

(2012) Christine A. Rabinak et al.   NEUROPHARMACOLOGY

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission

(2012) Alejandro Aparisi Rey et al.   NEUROPSYCHOPHARMACOLOGY

Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans

(2012) Andrea Dlugos et al.   NEUROPSYCHOPHARMACOLOGY

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response

(2011) M. N. Hill et al.   JOURNAL OF NEUROSCIENCE

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol

(2011) C.J. Roberts et al.   NEUROSCIENCE

Remission from post-traumatic stress disorder in the general population

(2011) C. Chapman et al.   PSYCHOLOGICAL MEDICINE

Impaired fear inhibition is a biomarker of PTSD but not depression

(2010) Tanja Jovanovic et al.   DEPRESSION AND ANXIETY

Fast Feedback Inhibition of the HPA Axis by Glucocorticoids Is Mediated by Endocannabinoid Signaling

(2010) Nathan K. Evanson et al.   ENDOCRINOLOGY

Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats

(2010) N.R. Sciolino et al.   NEUROSCIENCE

Endogenous cannabinoid signaling is essential for stress adaptation

(2010) M. N. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo

(2010) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

(2010) Douglas S. Johnson et al.   ACS Medicinal Chemistry Letters

Cannabinoids modulate hippocampal memory and plasticity

(2009) Hila Abush et al.   HIPPOCAMPUS

Impairments in Endocannabinoid Signaling and Depressive Illness

(2009) Matthew N. Hill   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cannabinoid Receptor Activation in the Basolateral Amygdala Blocks the Effects of Stress on the Conditioning and Extinction of Inhibitory Avoidance

(2009) E. Ganon-Elazar et al.   JOURNAL OF NEUROSCIENCE

Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic–Pituitary–Adrenal Axis

(2009) Matthew N Hill et al.   NEUROPSYCHOPHARMACOLOGY

An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics

(2009) Regina A. Mangieri et al.   PSYCHOPHARMACOLOGY

The Role of Prefrontal Cortex CB1 Receptors in the Modulation of Fear Memory

(2008) H.-C. Lin et al.   CEREBRAL CORTEX

Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats

(2008) Rafael M. Bitencourt et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms

(2008) Lucas De Oliveira Alvares et al.   NEUROBIOLOGY OF LEARNING AND MEMORY