Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis
出版年份 2022 全文链接
标题
Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis
作者
关键词
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出版物
MOLECULAR NEUROBIOLOGY
Volume 59, Issue 5, Pages 2855-2873
出版商
Springer Science and Business Media LLC
发表日期
2022-03-02
DOI
10.1007/s12035-022-02740-7
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- lncRNA MIR155HG Alleviates Depression-Like Behaviors in Mice by Regulating the miR-155/BDNF Axis
- (2021) Zhang Huan et al. NEUROCHEMICAL RESEARCH
- Long noncoding RNA growth arrest‐specific transcript 5 alleviates renal fibrosis in diabetic nephropathy by downregulating matrix metalloproteinase 9 through recruitment of enhancer of zeste homolog 2
- (2020) Lei Zhang et al. FASEB JOURNAL
- Long non-coding RNA GAS5 accelerates oxidative stress in melanoma cells by rescuing EZH2-mediated CDKN1C downregulation
- (2020) Wei Xu et al. Cancer Cell International
- Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression
- (2020) Orna Issler et al. NEURON
- Long non-coding RNA uc.80- overexpression promotes M2 polarization of microglias to ameliorate depression in rats
- (2020) Xun-Hu Gu et al. IUBMB LIFE
- EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice
- (2020) Wei Wang et al. JOURNAL OF AFFECTIVE DISORDERS
- EZH2: a novel target for cancer treatment
- (2020) Ran Duan et al. Journal of Hematology & Oncology
- Microglia: A Central Player in Depression
- (2020) Si-long Deng et al. Current Medical Science
- Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis
- (2020) Ben Bassett et al. BRAIN BEHAVIOR AND IMMUNITY
- Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-α in the Hippocampus
- (2020) Zhengrong Zhang et al. MOLECULAR NEUROBIOLOGY
- Downregulation of LncRNA Gas5 inhibits apoptosis and inflammation after spinal cord ischemia-reperfusion in rats
- (2020) Zaili Zhang et al. BRAIN RESEARCH BULLETIN
- Downregulation of lncRNA GAS5 Alleviates Hippocampal Neuronal Damage in Mice with Depression-Like Behaviors Via Modulation of MicroRNA-26a/EGR1 Axis
- (2020) Yigao Wu et al. Journal of Stroke & Cerebrovascular Diseases
- Ginsenoside Rg1 Prevents Chemotherapy-Induced Cognitive Impairment: Associations with Microglia-Mediated Cytokines, Neuroinflammation, and Neuroplasticity
- (2019) Dong-Dong Shi et al. MOLECULAR NEUROBIOLOGY
- Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus
- (2019) Lin-Lin Liu et al. BRAIN BEHAVIOR AND IMMUNITY
- Lidocaine Potentiates SOCS3 to Attenuate Inflammation in Microglia and Suppress Neuropathic Pain
- (2019) Yan Zheng et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors
- (2019) Yun Wang et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
- (2019) Burak I. Arioz et al. Frontiers in Immunology
- Altered expression of long noncoding RNAs in patients with major depressive disorder
- (2019) Tomoe Seki et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Ginsenoside Rg1 Exerts Anti-inflammatory Effects via G Protein-Coupled Estrogen Receptor in Lipopolysaccharide-Induced Microglia Activation
- (2019) Xian-Qi Gao et al. Frontiers in Neuroscience
- Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways
- (2019) Xiao Huang et al. ACTA PHARMACOLOGICA SINICA
- Ginsenosides Rb1 and Rg1 Protect Primary Cultured Astrocytes against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Improving Mitochondrial Function
- (2019) Meng Xu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis
- (2019) Xiaoyuan Zhu et al. MOLECULAR IMMUNOLOGY
- Knockdown of GAS5 Inhibits Atherosclerosis Progression via Reducing EZH2-Mediated ABCA1 Transcription in ApoE−/− Mice
- (2019) Xiang-Dong Meng et al. Molecular Therapy-Nucleic Acids
- Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway
- (2018) Li-Ping Xue et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Nrf2-Keap1 signaling in oxidative and reductive stress
- (2018) Ilaria Bellezza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3
- (2018) Xingli Zhang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
- (2018) Adam K. Walker et al. MOLECULAR PSYCHIATRY
- Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
- (2018) Moataz Abdalkader et al. Frontiers in Neuroscience
- Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
- (2018) Shi-feng Chu et al. ACTA PHARMACOLOGICA SINICA
- Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats
- (2018) Hongluan Yu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats
- (2018) Cuiqin Fan et al. Frontiers in Immunology
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Mitochondrial Dysfunction in Depression
- (2016) Yashika Bansal et al. Current Neuropharmacology
- Cellular and molecular basis for stress-induced depression
- (2016) J-S Seo et al. MOLECULAR PSYCHIATRY
- Pathogenesis of depression: Insights from human and rodent studies
- (2016) C. Ménard et al. NEUROSCIENCE
- Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway
- (2015) JIAYIN GAO et al. ONCOLOGY REPORTS
- Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease
- (2015) Wenda Jiang et al. PHARMACOLOGY
- The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2
- (2014) Ziming Li et al. FEBS LETTERS
- Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus
- (2012) Bo Jiang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mitochondria: In Sickness and in Health
- (2012) Jodi Nunnari et al. CELL
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