Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

Principles and functions of pericentromeric satellite DNA clustering into chromocenters

(2022) Franziska Brändle et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

(2020) Fabian Erdel et al.   MOLECULAR CELL

DNA repair by Rad52 liquid droplets

(2020) Roxanne Oshidari et al.   Nature Communications

How to maintain the genome in nuclear space

(2020) Ioanna Mitrentsi et al.   CURRENT OPINION IN CELL BIOLOGY

Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters

(2020) Christian Umkehrer et al.   NATURE BIOTECHNOLOGY

A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks

(2019) Thomas Clouaire et al.   TRENDS IN GENETICS

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair

(2019) Aline Marnef et al.   GENES & DEVELOPMENT

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

A conserved function for pericentromeric satellite DNA

(2018) Madhav Jagannathan et al.   eLife

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

(2016) Rebecca Kring Hansen et al.   NATURE CELL BIOLOGY

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

(2016) Daniël O. Warmerdam et al.   Cell Reports

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

Spatiotemporal regulation of Heterochromatin Protein 1- alpha oligomerization and dynamics in live cells

(2015) Elizabeth Hinde et al.   Scientific Reports

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

(2015) Shane M. Harding et al.   Cell Reports

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

(2015) Alkmini Kalousi et al.   Cell Reports

Chromatin Dynamics during DNA Repair Revealed by Pair Correlation Analysis of Molecular Flow in the Nucleus

(2014) Elizabeth Hinde et al.   BIOPHYSICAL JOURNAL

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage

(2014) Dorthe H. Larsen et al.   NATURE CELL BIOLOGY

Differential contribution of HP1 proteins to DNA end resection and homology-directed repair

(2013) Gaston Soria et al.   CELL CYCLE

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks

(2012) Tibor Pankotai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

(2011) Burkhard Jakob et al.   NUCLEIC ACIDS RESEARCH

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow

(2010) E. Hinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Barriers to Diffusion by Pair Correlation Functions

(2009) Michelle A. Digman et al.   BIOPHYSICAL JOURNAL

Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin

(2009) Aurélien Bancaud et al.   EMBO JOURNAL

Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes

(2009) Carola Engler et al.   PLoS One

Stoichiometry of molecular complexes at adhesions in living cells

(2009) M. A. Digman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the Number of Molecules and Brightness in the Laser Scanning Microscope

(2007) Michelle A. Digman et al.   BIOPHYSICAL JOURNAL