Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

(2012) Tamir Chandra et al.   MOLECULAR CELL

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

(2012) Zhen Shao et al.   GENOME BIOLOGY

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

(2011) D. T. Ting et al.   SCIENCE

Involvement of CENP-F in histone methylation

(2010) J. Du et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Age-associated increase in heterochromatic marks in murine and primate tissues

(2010) Jill A. Kreiling et al.   AGING CELL

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses

(2010) K. Maehara et al.   MOLECULAR AND CELLULAR BIOLOGY

Defective Lamin A-Rb Signaling in Hutchinson-Gilford Progeria Syndrome and Reversal by Farnesyltransferase Inhibition

(2010) Jackleen Marji et al.   PLoS One

Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci

(2010) Alyssa L Kennedy et al.   Cell Division

Higher-order Genome Organization in Human Disease

(2010) T. Misteli   Cold Spring Harbor Perspectives in Biology

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA hypomethylation in cancer cells

(2009) Melanie Ehrlich   Epigenomics

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation

(2008) Melanie Ehrlich et al.   AUTOIMMUNITY

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

(2008) Rajini Mudhasani et al.   JOURNAL OF CELL BIOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY