Article
Biochemistry & Molecular Biology
Giulia Sierri, Roberta Dal Magro, Barbara Vergani, Biagio Eugenio Leone, Beatrice Formicola, Lorenzo Taiarol, Stefano Fagioli, Marcelo Kravicz, Lucio Tremolizzo, Laura Calabresi, Francesca Re
Summary: Astrocytes in the brain are responsible for cholesterol synthesis, but in Alzheimer's disease, astrocytosis occurs, affecting cholesterol metabolism. Aβ-induced astrocytosis impairs cholesterol efflux, possibly due to reduced levels of ABCA1 transporters. Biomimetic HDLs have been designed to promote cholesterol efflux from astrocytes and show potential as a supportive treatment for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lei Chen, Zhen-Wang Zhao, Peng-Hui Zeng, Ying-Jie Zhou, Wen-Jun Yin
Summary: The maintenance of cellular cholesterol homeostasis is crucial for normal cell function and viability. Excessive cholesterol accumulation is the molecular basis of many diseases. Peripheral cells eliminate excessive cholesterol through cholesterol efflux, which is mainly mediated by ATP-binding cassette transporter A1 (ABCA1). This article focuses on the mechanisms underlying ABCA1-mediated cholesterol efflux, providing important insights for future investigation and lipid-lowering therapy.
Review
Biochemistry & Molecular Biology
Shiraz Dib, Jens Pahnke, Fabien Gosselet
Summary: ABCA7 plays a central role in Alzheimer's disease by regulating molecular processes such as cholesterol metabolism and amyloid processing, impacting the onset and development of late onset Alzheimer disease. Its functions are implicated in brain functioning and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Antonino Picataggi, Amrith Rodrigues, Debra A. Cromley, Hu Wang, Joel P. Wiener, Viktor Garliyev, Jeffrey T. Billheimer, Brian C. Grabiner, Jessica A. Hurt, Allen C. Chen, Xianlin Han, Daniel J. Rader, Domenico Pratico, Nicholas N. Lyssenko
Summary: ABCA7 functions differently from ABCA1 in lipid efflux and HDL synthesis. ABCA7 exhibits more efficient efflux of serine-lipid and phosphatidylinositol to apo A-I, but less efflux of cholesterol compared to ABCA1. Shotgun lipidomic analysis reveals lower phosphatidylcholine content and higher serine-lipid and phosphatidylinositol content in ABCA7-HDL, whereas ABCA1-HDL contains more cholesterol.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Biochemistry & Molecular Biology
Alexander D. Dergunov, Dmitry Y. Litvinov, Artem A. Malkov, Veronika B. Baserova, Elena Nosova, Liudmila Dergunova
Summary: The study investigated the denaturation of HDL and the dissociation of apoA-I in relation to cholesterol efflux from macrophages. Factors influencing apoA-I dissociation from HDL include phospholipid concentration, compositional and structural heterogeneity, and partition between aqueous and lipid phases. The release of apoA-I enhances ABCA1-mediated cholesterol efflux, suggesting apoA-I dissociation as a new functional property of HDL.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biology
Jialiang Yang, Yuhong Chen, Tongdan Zou, Bai Xue, Fang Yang, Xiangzhou Wang, Yibo Huo, Boyun Yan, Yuxia Xu, Shiyu He, Yi Yin, Jing Wang, Xiong Zhu, Lin Zhang, Yu Zhou, Zhengfu Tai, Ping Shuai, Man Yu, Qian Luo, Yilian Cheng, Bo Gong, Xianjun Zhu, Jing Zhang, Xinghuai Sun, Ying Lin, Houbin Zhang, Zhenglin Yang
Summary: This study reveals that lower ABCA1 expression and lower HDL are risk factors for primary open-angle glaucoma (POAG). Ablation of Abca1 in mice leads to elevated cholesterol levels in the retina, causing a POAG-like phenotype. Treatment with atorvastatin reduces cholesterol levels in the retina, improving metabolism and protecting retinal ganglion cells.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Summary: By using simulations, the authors of this study uncover the mechanism by which ATP-binding cassette transporter A1 (ABCA1) functions in extracting lipids from the outer face of the plasma membrane and facilitating the production of high density lipoprotein (HDL). Contrary to existing models, their findings suggest that ABCA1 removes lipids from the plasma membrane and forces them through its gateway and annulus into an elongated hydrophobic tunnel. This study provides important insights into the function of ABCA1 and presents a potential target for further research.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Masatsune Ogura
Summary: Homozygotes with loss-of-function mutations in ABCA1 develop Tangier disease, which is characterized by significantly reduced or absent blood high-density lipoprotein (HDL) cholesterol. ABCA1 was identified as a key player in HDL production based on studies involving ABCA1-deficient mice. While the activation of ABCA1 and promotion of cholesterol efflux could potentially lead to the development of anti-atherosclerotic drugs, it is challenging to consider simple ABCA1 activation or cholesterol efflux promotion as an effective strategy for intracellular cholesterol homeostasis. Currently, there is no evidence supporting the preventive effect of HDL-increasing drugs that enhance ABCA1 expression on atherosclerotic disease in humans. However, in situations where intracellular cholesterol homeostasis is disrupted by inflammation, aging, or metabolic abnormalities, restoring ABCA1 expression and cholesterol efflux may be a useful strategy.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Sumiko Abe-Dohmae, Shinji Yokoyama
Summary: ABCA7 is a membrane protein belonging to the ABC transporter family, showing differences in function compared to ABCA1. It plays a role in regulating the host defense system rather than in lipid metabolism. Its activity is negatively regulated by the SREBP system and may be a potential target for managing Alzheimer's disease through modulation of cholesterol metabolism.
Review
Health Care Sciences & Services
Jing Wang, Qianqian Xiao, Luyun Wang, Yan Wang, Daowen Wang, Hu Ding
Summary: ABCA1 plays a significant role in cholesterol homeostasis and inflammation inhibition, and decreased expression of ABCA1 is associated with an increased risk of cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ryoko Shinohata, Misako Shibakura, Yujiro Arao, Shogo Watanabe, Satoshi Hirohata, Shinichi Usui
Summary: A high-fat/high-cholesterol diet increases serum levels of apoE-rich HDL, while a high-cholesterol diet does not. This study investigates the effects of dietary fat and cholesterol on gene expression and HDL production. The results suggest that increased apoE-rich HDL induced by fat and cholesterol may be mediated by increased ABCA1-mediated cholesterol efflux from the liver.
Article
Endocrinology & Metabolism
Yuetao Zhang, Yue Wang
Summary: The study found that the HDL-C/ApoA-I ratio can more stably predict fasting glucose levels, guiding better in predicting blood sugar levels, and the negative correlation between HDL-C/ApoA-I ratio and FBG levels gradually strengthens as blood glucose levels increase.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Genetics & Heredity
Ghada M. A. Ajabnoor, Suhad M. Bahijri, Wafa Alrashidi, Sumia Mohammad Enani, Aliaa A. Alamoudi, Lubna Al Sheikh, Basmah Eldakhakhny
Summary: Studies suggest that there is an association between ATP-binding cassette transporter A1 (ABCA1 C69T) gene polymorphism and the risk of type 2 diabetes mellitus (T2DM) and dyslipidemia in diabetic individuals. However, contradictory findings exist. This study aimed to investigate the prevalence of ABCA1 C69T gene polymorphism in a representative sample of the Saudi population and its possible association with dyslipidemia and dysglycemia. The results showed that the T allele of ABCA1 C69T gene polymorphism was associated with dysglycemia but not dysregulation of lipid parameters.
Review
Cardiac & Cardiovascular Systems
Yang Wang, Min Guo, Chao-Ke Tang
Summary: This paper analyzes the history, hotspot, and development trend of ATP-binding cassette protein A1 (ABCA1) through bibliometrics. The research on ABCA1 is still hot in the past 20 years and it has emerged in previously unrelated disciplines such as cancer. The relationship between cancer and cardiovascular disease has been linked by ABCA1.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)