Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters

Rational design of ASCT2 inhibitors using an integrated experimental-computational approach

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Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds

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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

(2018) Amanda J Scopelliti et al.   Nature Communications

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

(2018) Angelika Bröer et al.   Frontiers in Pharmacology

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

(2018) Rachel-Ann A. Garibsingh et al.   Frontiers in Chemistry

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport

(2016) Michael L. Schulte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

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Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2

(2013) Catherine B. Zander et al.   JOURNAL OF GENERAL PHYSIOLOGY

The SLC1 high-affinity glutamate and neutral amino acid transporter family

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How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells

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An improved protocol for the preparation of (S)-vinylglycine from (S)-methionine

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Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Glutamine addiction: a new therapeutic target in cancer

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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