Aquaporin-4 and Alzheimer’s Disease

Amyloid-β Induces Cyclooxygenase-2 and PGE2 Release in Human Astrocytes in NF-κ B Dependent Manner

(2017) Almudena Blanco et al.   JOURNAL OF ALZHEIMERS DISEASE

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Aβ Clearance, “hub” of Multiple Deficiencies Leading to Alzheimer Disease

(2015) Pasquale Gallina et al.   Frontiers in Aging Neuroscience

Neurogranin Levels in Cerebrospinal Fluid

(2015) Henrik Zetterberg et al.   JAMA Neurology

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy

(2014) Cheryl A. Hawkes et al.   BRAIN PATHOLOGY

Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders

(2014) Ming Xiao et al.   CNS Neuroscience & Therapeutics

Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability

(2014) Feng Ru Tang et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

GLT-1 transporter: An effective pharmacological target for various neurological disorders

(2014) Neha Soni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Biology of AQP4 and Anti-AQP4 Antibody: Therapeutic Implications for NMO

(2013) A. S. Verkman et al.   BRAIN PATHOLOGY

Glia Protein Aquaporin-4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze

(2013) Ji Zhang et al.   CNS Neuroscience & Therapeutics

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

(2012) Nadia Nabil Haj-Yasein et al.   GLIA

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

(2012) Akihiko Hoshi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aquaporin-4 mediates astrocyte response to β-amyloid

(2012) Wei Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression

(2012) Yan-Kun Li et al.   NEUROPSYCHOPHARMACOLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Aquaporin-4 promotes memory consolidation in Morris water maze

(2011) Yi Fan et al.   Brain Structure & Function

Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4

(2011) V. A. Skucas et al.   JOURNAL OF NEUROSCIENCE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Aquaporin Expression in the Brains of Patients With or Without Cerebral Amyloid Angiopathy

(2010) Parham Moftakhar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

(2010) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy

(2009) Seth Love   Frontiers in Bioscience-Landmark

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Altered blood–brain barrier integrity in adult aquaporin-4 knockout mice

(2009) Jianping Zhou et al.   NEUROREPORT

AQP4 gene deletion in mice does not alter blood–brain barrier integrity or brain morphology

(2009) S. Saadoun et al.   NEUROSCIENCE

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

(2009) Roy O Weller et al.   Alzheimers Research & Therapy

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Aquaporin water channels in mammals

(2008) Kenichi Ishibashi et al.   Clinical and Experimental Nephrology

Aquaporins—new players in cancer biology

(2008) A. S. Verkman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY