Copper(II) Complexes of Halogenated Quinoline Schiff Base Derivatives Enabled Cancer Therapy through Glutathione-Assisted Chemodynamic Therapy and Inhibition of Autophagy Flux

Biomedicine Meets Fenton Chemistry

(2021) Zhongmin Tang et al.   CHEMICAL REVIEWS

One-Pot Synthesis-Biocompatible Copper–Tripeptide Complex as a Nanocatalytic Medicine to Enhance Chemodynamic Therapy

(2021) Zu-E. Hu et al.   ACS Biomaterials-Science & Engineering

ZIF‐Based Nanoparticles Combine X‐Ray‐Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy

(2021) Yanli Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Boosting tumor treatment by dredging the hurdles of chemodynamic therapy synergistic ion therapy

(2021) Junjie Liu et al.   CHEMICAL ENGINEERING JOURNAL

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca2+ Overload and Autophagy Inhibition

(2021) Xuan Wang et al.   ACS Applied Materials & Interfaces

Effects of Replacing Oxygenated Functionality with Fluorine on Lipophilicity

(2021) Richard J. Glyn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemodynamic therapy agents Cu(II) complexes of quinoline derivatives induced ER stress and mitochondria-mediated apoptosis in SK-OV-3 cells

(2021) Wen-Ying Shen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy

(2021) Pei-Ru Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function

(2021) Meng-ya Geng et al.   Cell Death & Disease

Activatable autophagy inhibition-primed chemodynamic therapy via targeted sandwich-like two-dimensional nanosheets

(2021) Hongshuai Wu et al.   CHEMICAL ENGINEERING JOURNAL

Tumor-Targeted Supramolecular Catalytic Nanoreactor for Synergistic Chemo/Chemodynamic Therapy via Oxidative Stress Amplification and Cascaded Fenton Reaction

(2020) Xiaoyu Xu et al.   CHEMICAL ENGINEERING JOURNAL

Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

(2020) Zhao Wang et al.   ACS Applied Materials & Interfaces

Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent

(2020) Xing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

New copper complexes inducing bimodal death through apoptosis and autophagy in A549 cancer cells

(2020) Noor Shad Gul et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Specifically Generation of Singlet Oxygen via Russell Mechanism in Hypoxic Tumor and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy

(2019) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer‐Specific Therapy by Artificial Modulation of Intracellular Calcium Concentration

(2019) Cheng Wang et al.   Advanced Healthcare Materials

A pH-responsive platform combining chemodynamic therapy with limotherapy for simultaneous bioimaging and synergistic cancer therapy

(2019) Jianmin Xiao et al.   BIOMATERIALS

GSH‐Depleted PtCu 3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

(2019) Xiaoyan Zhong et al.   ADVANCED FUNCTIONAL MATERIALS

Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

(2019) Ziyan Zhang et al.   Autophagy

Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resistance

(2019) Zhikun Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate

(2018) Zhongping Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

(2018) Ke-Bin Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction

(2018) Zhongmin Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands

(2018) Jungang Deng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction

(2018) Hadi Ranji-Burachaloo et al.   ACS Nano

New Water-Soluble Copper(II) Complexes with Morpholine–Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action

(2018) Kateryna Ohui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

(2017) Harshini Neelakantan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Facile Ion-Doping Strategy To Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics

(2017) Jing Bai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct one-pot synthesis of 3-nitroquinolin-2( 1H )-one via H 2 O/AcOH system: An improvement to classical Friedlander reaction

(2017) Xin-fei Chen et al.   TETRAHEDRON LETTERS

Trimetazidine restores the positive adaptation to exercise training by mitigating statin-induced skeletal muscle injury

(2017) Ming Song et al.   Journal of Cachexia Sarcopenia and Muscle

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Biofilm Impeding AgNPs Target Skin Carcinoma by Inducing Mitochondrial Membrane Depolarization Mediated through ROS Production

(2016) Debasis Nayak et al.   ACS Applied Materials & Interfaces

Copper(II)-Graphitic Carbon Nitride Triggered Synergy: Improved ROS Generation and Reduced Glutathione Levels for Enhanced Photodynamic Therapy

(2016) Enguo Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Lipophilic Pt(IV) Oxaliplatin Derivative Enhances Antitumor Activity

(2016) Aiman Abu Ammar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of High Basal Level of Autophagy Induces Apoptosis in Human Bladder Cancer Cells

(2016) Yi-Chia Lin et al.   JOURNAL OF UROLOGY

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Water-Soluble Ruthenium(II) Complexes with Chiral 4-(2,3-Dihydroxypropyl)-formamide Oxoaporphine (FOA): In Vitro and in Vivo Anticancer Activity by Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Induction of Tumor Cell Apoptosis

(2015) Zhen-Feng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chiral Phosphoric Acid-Catalyzed Asymmetric Transfer Hydrogenation of Quinolin-3-amines

(2014) Xian-Feng Cai et al.   ORGANIC LETTERS

The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes

(2013) Chen Qian et al.   Metallomics

TCM Active Ingredient Oxoglaucine Metal Complexes: Crystal Structure, Cytotoxicity, and Interaction with DNA

(2012) Zhen-Feng Chen et al.   INORGANIC CHEMISTRY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE