Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

(2021) Yong Won Choi et al.   Advanced Science

Cucurbitacin B exhibits antitumor effects on CD133+ HepG2 liver cancer stem cells by inhibiting JAK2/STAT3 signaling pathway

(2021) Xiaoli Wang et al.   ANTI-CANCER DRUGS

Cucurbitacin B induces apoptosis of primary effusion lymphoma via disruption of cytoskeletal organization

(2021) Mikinori Ueno et al.   PHYTOMEDICINE

Bufalin targets the SRC-3/MIF pathway in chemoresistant cells to regulate M2 macrophage polarization in colorectal cancer

(2021) Jinbao Chen et al.   CANCER LETTERS

Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects

(2021) Jiang Wan et al.   MOLECULES

New insights into M1/M2 macrophages: key modulators in cancer progression

(2021) Jiuyang Liu et al.   Cancer Cell International

Characterizing macrophage diversity in metastasis-bearing lungs reveals a lipid-associated macrophage subset

(2021) Danielle N. Huggins et al.   CANCER RESEARCH

Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β‐serum amyloid A1 axis

(2021) Gota Sudo et al.   CANCER SCIENCE

Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?

(2021) Constantin Stefani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients

(2021) Takehito Yamamoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2/FOXO1 signaling

(2021) Xiao Lang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis

(2021) Renyikun Yuan et al.   PHARMACOLOGICAL RESEARCH

Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer

(2021) Meng-Hua Chen et al.   PHARMACOLOGICAL RESEARCH

Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response

(2021) Manuela Del Cornò et al.   Cells

Cucurbitacin B Inhibits Cell Proliferation by Regulating X-Inactive Specific Transcript Expression in Tongue Cancer

(2021) Boqiang Tao et al.   Frontiers in Oncology

Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration

(2021) Jinglin Zhu et al.   Cancer Cell International

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

(2020) Azucena Salas et al.   Nature Reviews Gastroenterology & Hepatology

Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation

(2020) Llipsy Santiago et al.   Cell Reports

Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers

(2020) Irina Larionova et al.   Frontiers in Oncology

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

(2020) Muyue Yang et al.   Bioactive Materials

Ontogeny of Tumor-Associated Macrophages

(2019) Marie Laviron et al.   Frontiers in Immunology

Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy

(2019) Grégory Verdeil et al.   Cancers

Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer

(2019) Wei Li et al.   Cell Death & Disease

Physalin D regulates macrophage M1/M2 polarization via the STAT1/6 pathway

(2018) Ning Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

(2017) Ting-ting Wang et al.   GUT

Pleural Effusion of Patients with Malignant Mesothelioma Induces Macrophage-Mediated T Cell Suppression

(2016) Lysanne A. Lievense et al.   Journal of Thoracic Oncology

EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation

(2016) J Wu et al.   ONCOGENE

Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines

(2015) AS Yar Saglam et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition

(2015) Sun Young Park et al.   NEUROSCIENCE LETTERS

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer

(2010) Gabriela B Iwanski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH