Review
Cell & Tissue Engineering
Xiaofeng Qi, Yali Luo, Mengyong Xiao, Qiuju Zhang, Jing Luo, Linna Ma, Linfeng Ruan, Nini Lian, Yongqi Liu
Summary: This article reviews the major death modes of AT2 cells and compares the various forms of death, revealing their unique action mechanisms and partially overlapping pathways. Studying the mechanism of AT2 cell death is helpful in restoring the barrier function of AECs and provides new ideas and strategies for preventing and treating ALI.
Article
Pharmacology & Pharmacy
Anantha Harijith, Prathima Basa, Alison Ha, Jaya Thomas, Anjum Jafri, Panfeng Fu, Peter M. MacFarlane, Thomas M. Raffay, Viswanathan Natarajan, Tara Sudhadevi
Summary: This study aimed to determine the possible role of AT2 epithelial cell NOX4 in epithelial cell death from hyperoxic acute lung injury (HALI). The results demonstrated that deletion of the Nox4 gene or silencing NOX4 can attenuate epithelial cell apoptosis and mitochondrial ROS production, thus protecting the lungs from severe lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yonghong Jian, Yifei Yang, Lingli Cheng, Xueyan Yang, Hongyan Liu, Wei Li, Yuhan Wan, Dingping Yang
Summary: This study identifies Sirt3 as a vital factor in protecting against LPS-induced mitochondrial damage and apoptosis in TECs through the YME1L1-OPA1 signaling pathway.
CELL PROLIFERATION
(2023)
Article
Medicine, Research & Experimental
Wen-Jing Zhong, Jun Zhang, Jia-Xi Duan, Chen-Yu Zhang, Sheng-Chao Ma, Yu-Sheng Li, Nan-Shi-Yu Yang, Hui-Hui Yang, Jian-Bing Xiong, Cha-Xiang Guan, Zhi-Xing Jiang, Zhi-Jian You, Yong Zhou
Summary: In this study, it was found that activation of TREM-1 induces necroptosis of alveolar macrophages and aggravates acute lung injury (ALI). The study also revealed that mTOR-dependent mitochondrial fission is the underlying mechanism of TREM-1-induced necroptosis and inflammation. Therefore, targeting TREM-1 to regulate necroptosis may provide a new therapeutic approach for ALI in the future.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Liangjun Xia, Chunli Zhang, Nianyin Lv, Zihao Liang, Tonghui Ma, Haibo Cheng, Youbing Xia, Liyun Shi
Summary: AdMSC-Exos effectively donate mitochondrial components to improve macrophage mitochondrial integrity and oxidative phosphorylation, leading to the restoration of metabolic and immune homeostasis in airway macrophages and alleviating lung inflammatory pathology.
Article
Immunology
Su Hwan Lee, Ju Hye Shin, Min Woo Park, Junhyung Kim, Kyung Soo Chung, Sungwon Na, Ji-Hwan Ryu, Jin Hwa Lee, Moo Suk Park, Young Sam Kim, Jong-Seok Moon
Summary: The impairment of mitochondrial ATP synthesis may induce RIPK3-dependent necroptosis in lung epithelial cells during lung injury by lung inflammation, exacerbating lung tissue damage.
Article
Plant Sciences
Yapeng Hou, Jun Li, Yan Ding, Yong Cui, Hongguang Nie
Summary: The study found that Luteolin can alleviate pulmonary edema by enhancing the abundance of membrane ENaC, at least partially through the cGMP/PI3K pathway, providing a promising therapeutic strategy for treating ALI/ARDS.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Tengyue Zhang, Mengyuan Li, Siyuan Zhao, Mianjing Zhou, Huai Liao, Haiyan Wu, Xinyue Mo, Hongxing Wang, Chaohuan Guo, Hui Zhang, Niansheng Yang, Yuefang Huang
Summary: This study found that CaMK4 activation contributes to the activation of NLRP3 inflammasome during acute lung injury (ALI), and inhibiting CaMK4 can reduce the development of ALI and inflammation. These findings suggest that CaMK4 inhibition may be a novel therapeutic approach for the treatment of ALI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ping Zhan, Xue Lu, Zhao Li, Wen-Jing Wang, Kun Peng, Nan-Nan Liang, Yan Wang, Jian Li, Lin Fu, Hui Zhao, De-Xiang Xu, Zhu-Xia Tan
Summary: This study explored the role of mitochondrial reactive oxygen species (ROS) in bleomycin-induced acute lung injury (ALI) and ferroptosis of pulmonary epithelial cells. Mitochondria-targeted antioxidants may serve as potential therapeutic agents for bleomycin-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Fen Liu, Wei Peng, Jiaquan Chen, Zeyao Xu, Rong Jiang, Qiang Shao, Ning Zhao, Kejian Qian
Summary: The study revealed that AEC-derived exosomes activate AMs and induce pulmonary inflammation mediated by miR-92a-3p, indicating a novel disease mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan Ding, Lei Ma, Limin He, Quanxiao Xu, Zhuang Zhang, Zhen Zhang, Xinping Zhang, Rui Fan, Wenjun Ma, Ya 'nan Sun, Baile Zhang, Wentai Li, Yao Zhai, Jiandong Zhang
Summary: This study demonstrates the preventive effect of crocetin on radiation-induced lung injury, primarily achieved by inhibiting necroptosis. This work provides a new strategy for the prevention of lung radiation injury using extracts from Chinese herbal medicine.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Wenyang Jiang, Jie Ren, Hongling Zhou, Ruyuan He, Donghang Li, Rui Xiong, Zhuokun He, Dan Cheng
Summary: This study found that TMEM16A plays an important role in sepsis-induced acute lung injury (ALI) by regulating endoplasmic reticulum stress-induced ferroptosis in alveolar epithelial type II (AT2) cells. Knockout of TMEM16A improved lung function and alleviated lung pathological injury in LPS-treated mice. Inhibition of TMEM16A by shikonin also showed therapeutic effect on LPS-induced ALI in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yangyang Li, Anqi Zhang, Kuayue Li, Dahai Zhao, Feng Li, Songyan Liao, Yunting Zhang, Yan Huang
Summary: In this study, the researchers investigated the promoting effect of ASIC1a on LPS-induced ALI and its mechanisms. They found that ASIC1a induces apoptotic response in ALI through mitochondrial apoptosis. Pretreatment with the ASIC1a specific blocker PcTx-1 inhibited both the pathological changes of ALI and lung dysfunction. PcTx-1 also reduced the expression of apoptosis-related proteins and reversed the changes in mitochondrial membrane potential and calcium influx.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Yang, Lulu Wang, Yuehong Liang, Qingyu He, Qi Sun, Jing Luo, Hongdi Cao, Yi Fang, Yang Zhou, Junwei Yang, Ping Wen, Lei Jiang
Summary: Mitochondrial dysfunction, regulated by UCP2, plays a crucial role in the development of podocyte injury and proteinuria.
Article
Critical Care Medicine
Maomao Sun, Zhenhua Zeng, Gege Xu, Sheng An, Zhiya Deng, Ran Cheng, Yi Yao, Junjie Wu, Hongbin Hu, Qiaobing Huang, Jie Wu
Summary: This study revealed that the mitochondrial dynamics of alveolar macrophages (AMs) are imbalanced in sepsis and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), characterized by impaired mitochondrial fusion, increased fission, and mitochondrial cristae remodeling. Modulating mitochondrial dynamics by suppressing excessive fission or promoting fusion can inhibit the polarization of AMs into a proinflammatory phenotype and attenuate sepsis-induced ALI.