Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges

Heat shock induces premature transcript termination and reconfigures the human transcriptome

(2022) Simona Cugusi et al.   MOLECULAR CELL

On the evolution of chaperones and cochaperones and the expansion of proteomes across the Tree of Life

(2021) Mathieu E. Rebeaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

(2021) Netta Shemesh et al.   Nature Communications

The Interplay Between Disordered Regions in RNAs and Proteins Modulates Interactions Within Stress Granules and Processing Bodies

(2021) Andrea Vandelli et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteome plasticity in response to persistent environmental change

(2021) Matthew Domnauer et al.   MOLECULAR CELL

A heat shock–responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m6A modification

(2021) Quanquan Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress Granule-Mediated Oxidized RNA Decay in P-Body: Hypothetical Role of ADAR1, Tudor-SN, and STAU1

(2021) Ravi Kumar Alluri et al.   Frontiers in Molecular Biosciences

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

(2021) Raul Jobava et al.   MOLECULAR CELL

High-throughput quantification of protein structural change reveals potential mechanisms of temperature adaptation in Mytilus mussels

(2020) Ying-Chen Chao et al.   BMC EVOLUTIONARY BIOLOGY

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models

(2020) Rachel Kuta et al.   CELL STRESS & CHAPERONES

Stress- and ubiquitylation-dependent phase separation of the proteasome

(2020) Sayaka Yasuda et al.   NATURE

Imaging of DNA and RNA in Living Eukaryotic Cells to Reveal Spatiotemporal Dynamics of Gene Expression

(2020) Hanae Sato et al.   Annual Review of Biochemistry

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

(2020) Rebecca San Gil et al.   JOURNAL OF CELL SCIENCE

Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors

(2020) Stefan Bresson et al.   MOLECULAR CELL

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

Multicolour single-molecule tracking of mRNA interactions with RNP granules

(2019) Stephanie L. Moon et al.   NATURE CELL BIOLOGY

Protein Phase Separation as a Stress Survival Strategy

(2019) Titus M. Franzmann et al.   Cold Spring Harbor Perspectives in Biology

Functional Modules of the Proteostasis Network

(2019) Gopal G. Jayaraj et al.   Cold Spring Harbor Perspectives in Biology

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease

(2019) Richard I. Morimoto   Cold Spring Harbor Perspectives in Biology

The Organizing Principles of Eukaryotic Ribosome Recruitment

(2019) Jerry Pelletier et al.   Annual Review of Biochemistry

Regulation of the heat shock response in Escherichia coli: history and perspectives

(2019) Takashi Yura   GENES & GENETIC SYSTEMS

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin conformation remains stable upon extensive transcriptional changes driven by heat shock

(2019) Judhajeet Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pericentromeric protein shugoshin 2 cooperates with HSF 1 in heat shock response and RNA Pol II recruitment

(2019) Ryosuke Takii et al.   EMBO JOURNAL

Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning

(2019) Tyler Matheny et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural and functional analysis of the Hsp70/Hsp40 chaperone system

(2019) Qinglian Liu et al.   PROTEIN SCIENCE

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Heat acclimation-induced intracellular HSP70 in humans: a meta-analysis

(2019) Roberto Nava et al.   CELL STRESS & CHAPERONES

The Heat Shock Response in Yeast Maintains Protein Homeostasis by Chaperoning and Replenishing Proteins

(2019) Moritz Mühlhofer et al.   Cell Reports

Imaging mRNA In Vivo, from Birth to Death

(2018) Evelina Tutucci et al.   Annual Review of Biophysics

P-Bodies: Composition, Properties, and Functions

(2018) Yang Luo et al.   BIOCHEMISTRY

Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

(2018) Botond Penke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

Molecular mechanisms driving transcriptional stress responses

(2018) Anniina Vihervaara et al.   NATURE REVIEWS GENETICS

Stress pre-conditioning with temperature, UV and gamma radiation induces tolerance against phosphine toxicity

(2018) Saad M. Alzahrani et al.   PLoS One

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage

(2018) Nancy Standart et al.   TRENDS IN GENETICS

Translation Elongation and Recoding in Eukaryotes

(2018) Thomas E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Toward a Kinetic Understanding of Eukaryotic Translation

(2018) Masaaki Sokabe et al.   Cold Spring Harbor Perspectives in Biology

Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

(2018) Joanna Krakowiak et al.   eLife

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

(2018) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Effect of Exogenous Hsp70 in Mouse Models of Alzheimer's Disease

(2018) Natalia V. Bobkova et al.   JOURNAL OF ALZHEIMERS DISEASE

A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges

(2018) Xavier Pichon et al.   MOLECULAR CELL

O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response

(2018) Xingqian Zhang et al.   Nature Chemical Biology

mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction

(2018) Anthony Khong et al.   JOURNAL OF CELL BIOLOGY

Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway

(2018) Srivathsan Adivarahan et al.   MOLECULAR CELL

Widespread changes in nucleosome accessibility without changes in nucleosome occupancy during a rapid transcriptional induction

(2017) Britta Mueller et al.   GENES & DEVELOPMENT

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer’s Disease

(2017) Michail B. Evgen’ev et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of declining adaptive homeostasis in ageing

(2017) Laura C. D. Pomatto et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heat Shock Protein Genes Undergo Dynamic Alteration in Their Three-Dimensional Structure and Genome Organization in Response to Thermal Stress

(2017) Surabhi Chowdhary et al.   MOLECULAR AND CELLULAR BIOLOGY

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

m 6 A Facilitates eIF4F-Independent mRNA Translation

(2017) Ryan A. Coots et al.   MOLECULAR CELL

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional response to stress is pre-wired by promoter and enhancer architecture

(2017) Anniina Vihervaara et al.   Nature Communications

Eukaryotic elongation factor 2 kinase as a drug target in cancer and in cardiovascular and neurodegenerative diseases

(2016) Rui Liu et al.   ACTA PHARMACOLOGICA SINICA

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

(2016) Haishan Huang et al.   Autophagy

Targeting Hsp70: A possible therapy for cancer

(2016) Sanjay Kumar et al.   CANCER LETTERS

Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104

(2016) Elizabeth A. Sweeny et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress

(2016) Kenneth T. Farabaugh et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation

(2016) Dig B. Mahat et al.   MOLECULAR CELL

mRNA quality control is bypassed for immediate export of stress-responsive transcripts

(2016) Gesa Zander et al.   NATURE

Molecular basis of HSF regulation

(2016) Akira Nakai   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP

(2016) Rachel Ruoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Molecular basis of HSF regulation

(2016) Akira Nakai   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1

(2016) Nikolai Hentze et al.   eLife

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

(2016) Xu Zheng et al.   eLife

Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans

(2016) Daiana Silva Avila et al.   BMC Pharmacology & Toxicology

Integrated stress response of vertebrates is regulated by four eIF2α kinases

(2016) Shusuke Taniuchi et al.   Scientific Reports

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5′-Terminal Cap and Hairpin

(2015) Nadejda L. Korneeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chemical Biology of Molecular Chaperones—Implications for Modulation of Proteostasis

(2015) Kristoffer R. Brandvold et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing

(2015) Li Li et al.   MOLECULAR CELL

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Getting up to speed with transcription elongation by RNA polymerase II

(2015) Iris Jonkers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18

(2015) Xingqian Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18

(2015) Xingqian Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Gene Regulation: The HSP70 Gene Jumps When Shocked

(2014) Maria Vera et al.   CURRENT BIOLOGY

HSP70 Transgene Directed Motion to Nuclear Speckles Facilitates Heat Shock Activation

(2014) Nimish Khanna et al.   CURRENT BIOLOGY

Translational control by heme-regulated eIF2α kinase during erythropoiesis

(2014) Jane-Jane Chen   CURRENT OPINION IN HEMATOLOGY

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

(2014) P. van Oosten-Hawle et al.   GENES & DEVELOPMENT

Identification of Mixed Lineage Leukemia 1(MLL1) Protein as a Coactivator of Heat Shock Factor 1(HSF1) Protein in Response to Heat Shock Protein 90 (HSP90) Inhibition

(2014) Yaoyu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

Proteomics to study adaptations in marine organisms to environmental stress

(2014) Lars Tomanek   Journal of Proteomics

Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast

(2014) Brian M. Zid et al.   NATURE

Stress granules are dispensable for mRNA stabilization during cellular stress

(2014) Nadine Bley et al.   NUCLEIC ACIDS RESEARCH

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

(2014) Maria Vera et al.   eLife

Mechanisms of heat shock response in mammals

(2013) Artem K. Velichko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sensing temperature

(2013) Piali Sengupta et al.   CURRENT BIOLOGY

Insulin Secretion and Ca2+Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

(2013) Rong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cotranslational Response to Proteotoxic Stress by Elongation Pausing of Ribosomes

(2013) Botao Liu et al.   MOLECULAR CELL

Widespread Regulation of Translation by Elongation Pausing in Heat Shock

(2013) Reut Shalgi et al.   MOLECULAR CELL

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Heme-regulated eIF2  kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

(2012) R. N. V. S. Suragani et al.   BLOOD

eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

(2012) T. Alain et al.   CANCER RESEARCH

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Heme metabolism and erythropoiesis

(2012) Jacky Chung et al.   CURRENT OPINION IN HEMATOLOGY

ncRNAs and thermoregulation: A view in prokaryotes and eukaryotes

(2012) Mercedes de la Fuente et al.   FEBS LETTERS

Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System

(2012) J. Verghese et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

A mechanistic overview of translation initiation in eukaryotes

(2012) Colin Echeverría Aitken et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

(2012) A. G. Hinnebusch et al.   Cold Spring Harbor Perspectives in Biology

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae

(2011) K. A. Morano et al.   GENETICS

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

Keeping mRNPs in check during assembly and nuclear export

(2011) Evelina Tutucci et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the members of the mammalian heat shock factor family

(2010) Johanna K. Björk et al.   FEBS Journal

PI3K-mTORC1 Attenuates Stress Response by Inhibiting Cap-independent Hsp70 Translation

(2010) Jun Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variation in the heat shock response and its implication for predicting the effect of global climate change on species' biogeographical distribution ranges and metabolic costs

(2010) L. Tomanek   JOURNAL OF EXPERIMENTAL BIOLOGY

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

(2010) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Animal performance and stress: responses and tolerance limits at different levels of biological organisation

(2009) Karin S. Kassahn et al.   BIOLOGICAL REVIEWS

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Uncoupling Stress Granule Assembly and Translation Initiation Inhibition

(2009) Sophie Mokas et al.   MOLECULAR BIOLOGY OF THE CELL

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Rapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 Loci

(2008) Steven J. Petesch et al.   CELL

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Molecular mechanism of preconditioning

(2008) Manika Das et al.   IUBMB LIFE

Human Alu RNA Is a Modular Transacting Repressor of mRNA Transcription during Heat Shock

(2008) Peter D. Mariner et al.   MOLECULAR CELL

The Control of mRNA Decapping and P-Body Formation

(2008) Tobias M. Franks et al.   MOLECULAR CELL

A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly

(2008) Takbum Ohn et al.   NATURE CELL BIOLOGY

The Importance of Physiological Limits in Determining Biogeographical Range Shifts due to Global Climate Change: The Heat‐Shock Response

(2008) Lars Tomanek   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE