Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

(2019) Elisabeth Rossaert et al.   Acta Neuropathologica Communications

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease

(2018) Veronick Benoy et al.   BRAIN

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

(2018) Marcel Naumann et al.   Nature Communications

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

(2018) Toshiki Kijima et al.   Scientific Reports

Tailoring of Proteostasis Networks with Heat Shock Factors

(2018) Jenny Joutsen et al.   Cold Spring Harbor Perspectives in Biology

High content organelle trafficking enables disease state profiling as powerful tool for disease modelling

(2018) Arun Pal et al.   Scientific Data

Regulation of the mammalian heat shock factor 1

(2017) Sharadha Dayalan Naidu et al.   FEBS Journal

Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis

(2017) Michael Tibshirani et al.   HUMAN MOLECULAR GENETICS

Rethinking HSF1 in Stress, Development, and Organismal Health

(2017) Jian Li et al.   TRENDS IN CELL BIOLOGY

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

(2017) Wenting Guo et al.   Nature Communications

Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor

(2016) Yogesh K. Chutake et al.   NUCLEIC ACIDS RESEARCH

Lysine Deacetylases Regulate the Heat Shock Response Including the Age-Associated Impairment of HSF1

(2015) Elena Zelin et al.   JOURNAL OF MOLECULAR BIOLOGY

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

(2015) Marek A. Budzyński et al.   MOLECULAR AND CELLULAR BIOLOGY

Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1

(2014) Swasti Raychaudhuri et al.   CELL

Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1

(2014) Michael Tibshirani et al.   HUMAN MOLECULAR GENETICS

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

(2014) Haiyan Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of HDAC6 Modifies Tau Inclusion Body Formation and Impairs Autophagic Clearance

(2014) Janina Leyk et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

(2014) Lydia Pernet et al.   MOLECULAR BIOLOGY OF THE CELL

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

(2014) Maria Vera et al.   eLife

A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

(2013) Jieun R. C. Cha et al.   CELL STRESS & CHAPERONES

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

(2013) Adam S. Mastrocola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

(2013) Wen-Yuan Wang et al.   NATURE NEUROSCIENCE

Neuron-specific chromatin remodeling: A missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders

(2013) Annie Vogel-Ciernia et al.   NEUROPHARMACOLOGY

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

(2013) Peter Reinhardt et al.   PLoS One

Proteomic Analysis Reveals Differentially Regulated Protein Acetylation in Human Amyotrophic Lateral Sclerosis Spinal Cord

(2013) Dong Liu et al.   PLoS One

Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis

(2011) Young-Eun Yoo et al.   EXPERIMENTAL NEUROLOGY

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

(2010) Zoya Marinova et al.   NEUROPHARMACOLOGY

Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis

(2009) Sanne Piepers et al.   ANNALS OF NEUROLOGY

Arimoclomol: a potential therapy under development for ALS

(2009) Veena Lanka et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

(2009) Zoya Marinova et al.   JOURNAL OF NEUROCHEMISTRY

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells

(2008) R. Rao et al.   BLOOD

Stress-Dependent Dynamics of Global Chromatin Remodeling in Yeast: Dual Role for SWI/SNF in the Heat Shock Stress Response

(2008) S. Shivaswamy et al.   MOLECULAR AND CELLULAR BIOLOGY