Review
Medicine, General & Internal
Piotr Szwed, Aleksandra Gasecka, Mateusz Zawadka, Ceren Eyileten, Marek Postula, Tomasz Mazurek, Lukasz Szarpak, Krzysztof J. Filipiak
Summary: Atherosclerotic cardiovascular diseases are a major global cause of mortality, with infections and pathogens playing a role in their development and progression. In addition to traditional risk factors, infections should be considered as important non-classical risk factors, and early diagnosis and treatment are crucial for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Joshua D. Bundy, Mahboob Rahman, Kunihiro Matsushita, Byron C. Jaeger, Jordana B. Cohen, Jing Chen, Rajat Deo, Mirela A. Dobre, Harold I. Feldman, John Flack, Radhakrishna R. Kallem, James P. Lash, Stephen Seliger, Tariq Shafi, Shoshana J. Weiner, Myles Wolf, Wei Yang, Norrina B. Allen, Nisha Bansal, Jiang He, CRIC Study Investigators
Summary: This study developed 10-year ASCVD risk prediction models in patients with CKD, including novel biomarkers, which performed better than models using only traditional risk factors developed for the general population.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Tsung-Hui Wu, Yi-Chun Lin, Chii-Min Hwu
Summary: This study assessed the impact of isolated postchallenge hyperglycemia on 10-year atherosclerotic cardiovascular disease risk scores in postmenopausal women. The results showed that women with isolated postchallenge hyperglycemia had higher blood pressure, worse lipid profile, and increased 10-year ASCVD risk scores.
Article
Gastroenterology & Hepatology
Maria Pina Dore, Gian Luca Erre, Jessica Piroddu, Giovanni Mario Pes
Summary: In patients from Northern Sardinia, Italy, rheumatoid arthritis (RA) and Helicobacter pylori (H. pylori) infection were found to be risk-enhancer factors for atherosclerotic cardiovascular diseases (aCVD). After adjusting for confounding factors, patients with RA and LLHp infection had a significantly increased risk for aCVD.
Review
Cardiac & Cardiovascular Systems
Faraedon Zardawi, Sarhang Gul, Ali Abdulkareem, Aram Sha, Julian Yates
Summary: Periodontitis is potentially a risk factor for the development of atheroma in the arteries, highlighting the association between periodontal disease and atherosclerotic cardiovascular disease. Early diagnosis and treatment of periodontitis may be crucial in reducing complications associated with ACVDs. Further research with longer follow-up is needed to confirm the causal relationship between periodontal disease and ACVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Timoteo Marchini, Sara Malchow, Lourdes Caceres, Abed Al Hadi El Rabih, Sophie Hansen, Timothy Mwinyella, Lisa Spiga, Sven Piepenburg, Hauke Horstmann, Tijani Olawale, Xiaowei Li, Lucia Sol Mitre, Mark Colin Gissler, Heiko Bugger, Andreas Zirlik, Timo Heidt, Ingo Hilgendorf, Peter Stachon, Constantin von Zur Muehlen, Christoph Bode, Dennis Wolf
Summary: Using a novel assay, this study found that circulating human ApoB auto-antibodies are associated with cardiovascular risk factors but not with the clinical appearance of atherosclerosis. This finding suggests that humoral immune responses against ApoB are shaped by cardiovascular risk factors rather than the disease itself. This tool could be helpful for immune-based risk stratification in clinical atherosclerosis in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mie Balling, Shoaib Afzal, George Davey Smith, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Borge G. Nordestgaard
Summary: Elevated LDL triglycerides are associated with an increased risk of ASCVD and its individual components, as shown in two prospective cohort studies and meta-analyses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Stefan Acosta, Anna Johansson, Isabel Drake
Summary: This study found that adhering to a healthy diet, particularly increasing intake of fish, shellfish, fiber, and decreasing saturated fat intake, was associated with a reduced risk of ACVD. Additionally, high levels of leisure-time physical activity were found to reduce the risk of ACVD, while obesity was associated with an increased risk.
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jinjing Li, Jieqiong Zhao, Yonghong Lei, Yan Chen, Miaomiao Cheng, Xiaoqing Wei, Jing Liu, Pengyun Liu, Ruirui Chen, Xiaoqing Yin, Lei Shang, Xue Li
Summary: The study revealed a mutual risk between coronary atherosclerotic heart disease (CAD) and cancer. Digestive, respiratory, and urogenital cancers were identified as independent risk factors for CAD. Additionally, a formula for predicting cancer among CAD patients was developed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Giulia Germena, Laura Cecilia Zelarayan, Rabea Hinkel
Summary: Exosomes are small membranous vesicles that contain biological material and can mediate cell-to-cell communication, maintaining homeostasis or modulating disease processes. They play a crucial role in cardiovascular diseases and have potential diagnostic value, although their specific physiological and pathophysiological functions in the cardiovascular system are still not fully understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Health Care Sciences & Services
Yeong Chan Lee, Jiho Cha, Injeong Shim, Woong-Yang Park, Se Woong Kang, Dong Hui Lim, Hong-Hee Won
Summary: In this study, an artificial intelligence model was developed to identify cardiovascular disease using multimodal data including clinical risk factors and fundus photographs. The model achieved high accuracy in both validation datasets and suggested that fundus photography can serve as a possible predictive marker for CVD.
NPJ DIGITAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Stanislaw Surma, Maciej Banach
Summary: Atherosclerotic cardiovascular diseases (ASCVD) are a major cause of premature death worldwide. Biomarkers that can detect and assess the prognosis of ASCVD are highly sought after. Fibrinogen, a protein that increases in concentration in ASCVD patients, may serve as a biomarker for the disease and contribute to its development through genetic polymorphisms and post-translational modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Article
Medicine, General & Internal
Michelle T. Lee, Dhruv Mahtta, Liang Chen, Aliza Hussain, Mahmoud Al Rifai, Preetika Sinh, Umair Khalid, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani
Summary: This study found an association between inflammatory bowel disease and extremely premature atherosclerotic cardiovascular disease, especially in patients under 40 years of age. As patients age, this risk is attenuated by traditional cardiometabolic factors such as obesity, hypertension, diabetes, smoking, and dyslipidemia.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Anesthesiology
Takafumi Saito, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Yukiko Morisaki, Kozo Anno, Nobuyuki Sudo, Masako Hosoi, Toshiharu Ninomiya
Summary: This study aimed to examine the association between family dysfunction levels and the presence of chronic pain in a community-dwelling Japanese population. The results showed that family dysfunction levels were positively associated with the presence and severity of chronic pain. This suggests that social support or family therapy may be helpful in preventing or managing chronic pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Endocrinology & Metabolism
Mayu Higashioka, Yoichiro Hirakawa, Jun Hata, Takanori Honda, Satoko Sakata, Mao Shibata, Takanari Kitazono, Haruhiko Osawa, Toshiharu Ninomiya
Summary: This study found that serum M2BPGi concentrations were associated with the development of type 2 diabetes. A 7-year follow-up was conducted on 2143 Japanese individuals aged 40-79 years without diabetes at baseline. The age- and sex-adjusted cumulative incidence of type 2 diabetes significantly increased with elevating serum M2BPGi levels. This association remained significant after adjustment for potential confounders, but became nonsignificant after adjusting for inflammation and insulin resistance markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya
Summary: The aim of this study was to investigate the association between white matter lesions volume (WMLV) levels and dementia risk, as well as the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population. The study found that the risk of dementia significantly increased with higher levels of WMLV/ICV. Additionally, a additive increase in dementia risk was observed with higher levels of WMLV/ICV and lower levels of TBV/ICV or a higher number of dementia-related brain regional atrophy.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Urology & Nephrology
Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya
Summary: This study aimed to examine the associations between urinary albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) levels with brain atrophy and white matter lesion volume (WMLV) in a large-scale community-dwelling older population of Japanese. The results showed that higher UACR levels were significantly associated with lower total brain volume-to-intracranial volume ratio (TBV/ICV) and higher WMLV-to-ICV ratio. Lower eGFR levels were associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. Higher UACR levels were also associated with lower regional brain volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio.
Article
Clinical Neurology
Jessica Gong, Katie Harris, Darren M. Lipnicki, Erico Castro-Costa, Maria Fernanda Lima-Costa, Breno S. Diniz, Shifu Xiao, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Pierre-Marie Preux, Maelenn Guerchet, Antoine Gbessemehlan, Karen Ritchie, Marie-Laure Ancelin, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Mary H. Kosmidis, Antonio Guaita, Elena Rolandi, Annalisa Davin, Oye Gureje, Stella Trompet, Jacobijn Gussekloo, Steffi Riedel-Heller, Alexander Pabst, Susanne Rohr, Suzana Shahar, Devinder Kaur Ajit Singh, Nurul Fatin Malek Rivan, Martin van Boxtel, Sebastian Kohler, Mary Ganguli, Chung-Chou Chang, Erin Jacobsen, Mary Haan, Ding Ding, Qianhua Zhao, Zhenxu Xiao, Kenji Narazaki, Tao Chen, Sanmei Chen, Tze Pin Ng, Xinyi Gwee, Katya Numbers, Karen A. Mather, Marcia Scazufca, Antonio Lobo, Concepcion De-la-Camara, Elena Lobo, Perminder S. Sachdev, Henry Brodaty, Maree L. Hackett, Sanne A. E. Peters, Mark Woodward
Summary: This meta-analysis of data from 21 cohorts across six continents found that women have a higher risk of developing dementia than men, especially in low- and lower-middle-income economies. Longer education and former alcohol use are stronger risk factors for dementia in men than in women, while other risk factors have similar effects in both genders.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Takahiro Tajimi, Yoshihiko Furuta, Naoki Hirabayashi, Takanori Honda, Jun Hata, Tomoyuki Ohara, Mao Shibata, Tomohiro Nakao, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya
Summary: The study found that gait speed is associated with regional brain volumes and the risk of developing dementia. A total of 1112 dementia-free Japanese residents aged 65 years and older underwent brain MRI and were followed for 5 years. Lower gait speed was associated with smaller gray matter volumes and larger white matter hyper-intensities volumes. The risk of developing dementia significantly increased with decreasing gait speed.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Peripheral Vascular Disease
Takanori Honda, Sanmei Chen, Jun Hata, Mao Shibata, Yoshihiko Furuta, Emi Oishi, Satoko Sakata, Takanari Kitazono, Toshiharu Ninomiya
Summary: In a Japanese community, the serum EPA/AA ratio decreased over 10 years, especially in middle-aged participants.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Ophthalmology
Emi Ueda, Miho Yasuda, Kohta Fujiwara, Sawako Hashimoto, Takanori Honda, Shun Nakamura, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda
Summary: This study aims to investigate the association between choroidal thickness and myopic maculopathy. A total of 2841 residents aged > 40 years from a Japanese community were enrolled in the study. It was found that individuals with thinner choroidal thickness had a higher likelihood of myopic maculopathy. Therefore, measuring choroidal thickness in addition to axial length can be useful for assessing the risk and understanding the pathogenesis of myopic maculopathy.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Nursing
Qiongqiong Zhang, Bin Li, Jing Han, Sanmei Chen, Yongchao Lu, Shengnan Tang, Qingyan Wang
Summary: During the COVID-19 outbreak, family caregivers of individuals with dementia in China sought positivity amidst difficulties and experienced corresponding reactions, social support resources, and resilient coping strategies.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Public, Environmental & Occupational Health
Kenji Kawatoko, Yasuyoshi Washio, Tomoyuki Ohara, Satoru Fukuyama, Takanori Honda, Jun Hata, Taro Nakazawa, Keiko Kan-o, Hiromasa Inoue, Koichiro Matsumoto, Tomohiro Nakao, Takanari Kitazono, Isamu Okamoto, Toshiharu Ninomiya
Summary: The study found that PRISm was associated with an increased risk of dementia in the older Japanese population, indicating that PRISm could be a potential risk factor for dementia.
JOURNAL OF EPIDEMIOLOGY
(2023)
Correction
Peripheral Vascular Disease
Takanori Honda, Sanmei Chen, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Yoshihiko Furuta, Mao Shibata, Satoko Sakata, Takanari Kitazono, Toshiharu Ninomiya
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)