Article
Oncology
Judy C. C. Boughey, Kari M. M. Rosenkranz, Karla V. V. Ballman, Linda McCall, Bruce G. G. Haffty, Laurie W. W. Cuttino, Charlotte S. D. Kubicky, Huong T. T. Le-Petross, Armando E. E. Giuliano, Kimberly J. J. Van Zee, Kelly K. K. Hunt, Olwen M. M. Hahn, Lisa A. A. Carey, Ann H. H. Partridge
Summary: This study is a prospective trial to evaluate the effectiveness of breast-conserving therapy in patients with multiple foci of breast cancer. The results demonstrate that breast-conserving surgery with adjuvant radiation can significantly reduce the 5-year recurrence rate. It suggests that breast-conserving therapy is a reasonable option, especially for patients evaluated with preoperative breast MRI.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Caiqin Mo, Weihong Ruan, Junyu Lin, Huaying Chen, Xiangjin Chen
Summary: Repeat breast-conserving surgery (RBCS) has a higher secondary local recurrence rate compared to salvage mastectomy (SM) for patients with ipsilateral breast tumour recurrence (IBTR), but it does not significantly affect survival rates. RBCS may be considered as an alternative method for IBTR patients after breast-conserving surgery (BCS).
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Courtney E. Pisano, Michael Z. Kharouta, Eleanor E. Harris, Robert Shenk, Janice A. Lyons
Summary: This prospective study assessed the feasibility and efficacy of using APBI in patients who had prior whole breast irradiation, showing that APBI using IORT had excellent local control and may be a reasonable alternative to mastectomy for IBTR patients. Further research is needed to determine the most suitable candidates for this approach.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. M. Heaney, L. Sweeney, F. Flanagan, A. 'Brien, C. Smith
Summary: The study analysed stereotactic biopsies of microcalcifications in patients with previous ipsi-lateral breast-conserving surgery to identify factors associated with the risk of recurrence, such as positive margin status and types of calcifications.
CLINICAL RADIOLOGY
(2022)
Article
Oncology
Hiroshi Nakagomi, Masayuki Inoue, Yosuke Hirotsu, Kenji Amemiya, Hitoshi Mochiduki, Masao Omata
Summary: This study used genome profiling to reveal the association between Ipsilateral Breast Tumor Recurrence (IBTR) and abnormalities in the PIK3CA-AKT pathway, with a matching rate of 77% between clinical and genomic classifications.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Surgery
Damiano Gentile, Andrea Sagona, Erika Barbieri, Lidija Antunovic, Davide Franceschini, Agnese Losurdo, Bethania Fernandes, Corrado Tinterri
Summary: The study compared the long-term oncological outcomes of IBCR patients who had undergone either mastectomy or second BCS, showing that second BCS had significantly better DDFS, OS, and BCSS compared to salvage mastectomy.
UPDATES IN SURGERY
(2022)
Article
Oncology
Mingdi Zhang, Kejin Wu, Peng Zhang, Maoli Wang, Fang Bai, Hongliang Chen
Summary: BCS shows independent favorable prognostic factor and can be acceptable and preferable alternative to mastectomy for well-selected early-stage T1 or T2 CLBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Timothy J. Whelan, Sally Smith, Sameer Parpia, Anthony W. Fyles, Anita Bane, Fei-Fei Liu, Eileen Rakovitch, Lynn Chang, Christiaan Stevens, Julie Bowen, Sawyna Provencher, Valerie Theberge, Anna Marie Mulligan, Zuzana Kos, Mohamed A. Akra, K. David Voduc, Tarek Hijal, Ian S. Dayes, Gregory Pond, James R. Wright, Torsten O. Nielsen, Mark N. Levine
Summary: Among women with T1N0 grade 1 or 2 luminal A breast cancer who had undergone breast-conserving surgery and received endocrine therapy, the incidence of local recurrence at 5 years was low without radiotherapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Oncology
Fei-Lin Qu, Song-Yang Wu, Jun-Jie Li, Zhi-Ming Shao
Summary: Despite advances in surgical and radiation techniques, ipsilateral breast tumor recurrence (IBTR) still occurs in a small percentage of women treated with breast conservative treatment. Treatment guidelines for these patients are lacking, leading to inconsistent strategies. Furthermore, the methods for defining true recurrence and new primary tumor for IBTR are controversial. This editorial discusses current trends in surgical de-escalation for IBTR patients and highlights innovative approaches in molecular-integrated classification and multimodal staging for clinical practice and postoperative surveillance strategies.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Fei-Lin Qu, Cai-Jin Lin, Zhe-Bin Liu, A-Yong Cao, Jiong Wu, Guang-Yu Liu, Ke-Da Yu, Gen-Hong Di, Jun-Jie Li, Zhi-Ming Shao
Summary: This study aimed to evaluate the oncologic safety of omitting surgical axillary staging (SAS) for patients with ipsilateral breast tumor recurrence (IBTR) and negative nodes. Results showed that for node-negative IBTR patients, shorter recurrence interval and concordant molecular subtype favored no SAS. However, there were no significant differences in locoregional recurrence-free survival, distant metastasis-free survival, and overall survival between the SAS and no SAS groups.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Acoustics
E. Rascevska, L. C. M. Yip, P. Omidi, M. Brackstone, J. J. L. Carson
Summary: This study designed a low-frequency, hand-held photoacoustic imaging probe to evaluate the feasibility of assessing surgical margins in breast cancer. The results showed that the probe could detect optical absorption gaps as small as 1 mm and obtain strong signals from fatty tissue in imaging. This hand-held probe has the potential for detecting residual breast cancer tissue during breast conserving surgery.
Article
Medicine, General & Internal
Ian H. H. Kunkler, Linda J. J. Williams, Wilma J. L. Jack, David A. A. Cameron, J. Michael Dixon
Summary: This study suggests that omission of radiotherapy in older women with low-risk, hormone receptor-positive early breast cancer may increase the risk of local recurrence, but has no detrimental effect on distant recurrence and overall survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Concetta Blundo, Massimo Giroda, Nicola Fusco, Elham Sajjadi, Konstantinos Venetis, M. Cristina Leonardi, Elisa Vicini, Luca Despini, Claudia F. Rossi, Letterio Runza, Maria S. Sfondrini, Roberto Piciotti, Eugenia Di Loreto, Giovanna Scarfone, Elena Guerini-Rocco, Giuseppe Viale, Paolo Veronesi, Barbara Buonomo, Fedro A. Peccatori, Viviana E. Galimberti
Summary: This study investigated the feasibility and safety of breast-conserving surgery during the first trimester of pregnancy in women with early-stage breast cancer. The findings provide evidence that this approach is feasible and reasonably safe for both the mother and the baby.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Miyako Nara, Sakiko Ishihara, Atsuko Kitano, Nobuko Tamura, Tomoyuki Aruga, Daiki Kobayashi, Seigo Nakamura, Hideko Yamauchi
Summary: This study demonstrates that BRCA-mutation carriers who undergo BCS have a higher risk of IBTR, which increases with longer observation periods. However, there is no evidence to suggest a negative impact on overall survival with BCS.
Article
Oncology
Yong Li, Wei-wen Li, Lin Yuan, Bo Xu
Summary: This study compared the prognosis of repeat BCS and mastectomy in patients with IBTR, finding that repeat BCS was associated with worse overall survival and breast cancer-specific survival compared to mastectomy. The estrogen receptor status of IBTR was found to be an important factor in choosing repeat BCS, and radiation therapy may improve oncological safety after repeat BCS.
