Article
Medicine, General & Internal
Zhi-Hong Sun, Chuang Chen, Xin-Wen Kuang, Jun-Long Song, Sheng-Rong Sun, Wei-Xing Wang
Summary: This study found that, compared to mastectomy, breast-conserving therapy (BCT) can provide better breast cancer-specific survival and overall survival benefits in young white patients under 40 with early-stage breast cancer, especially in the 36 to 40 years age group.
Article
Oncology
Hakyoung Kim, Sae Byul Lee, Seok-Jin Nam, Eun Sook Lee, Byeong-Woo Park, Ho Yong Park, Hyouk Jin Lee, Jisun Kim, Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn
Summary: This study evaluated the long-term outcomes of Korean women with early breast cancer undergoing breast-conserving surgery plus radiotherapy or total mastectomy. Findings showed that the breast-conserving surgery plus radiotherapy group had better overall survival and breast cancer-specific survival than the total mastectomy group in both the Korean Breast Cancer Registry and Asan Medical Center cohorts. The results suggest that breast-conserving surgery plus radiotherapy is at least equivalent to total mastectomy in terms of overall survival and may influence treatment decisions for early breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Birgitte V. Offersen, Jan Alsner, Hanne M. Nielsen, Erik H. Jakobsen, Mette H. Nielsen, Lars Stenbygaard, Anders N. Pedersen, Mette S. Thomsen, Esben Yates, Martin Berg, Ebbe L. Lorenzen, Ingelise Jensen, Mirjana Josipovic, Maj-Britt Jensen, Jens Overgaard
Summary: External-beam PBI is noninferior to WBI in terms of breast induration for patients with low-risk breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Elizaveta Vasilyeva, Jeremy Hamm, Alan Nichol, Kathryn V. Isaac, Amy Bazzarelli, Carl Brown, Caroline Lohrisch, Elaine McKevitt
Summary: This study assessed the oncological outcomes of breast cancer patients using clinical nodal status as the criterion. The results showed that breast-conserving surgery (BCT) had better overall survival and breast cancer-specific survival compared to mastectomy for both clinically node-negative and node-positive patients, without an increased risk of locoregional recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Shi-Ping Yang, Lu-Lu Tan, Ping Zhou, Chen-Lu Lian, San-Gang Wu, Zhen-Yu He
Summary: The study aimed to evaluate the association between adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) and survival among elderly breast cancer patients. The results showed that patients who received adjuvant RT had better breast cancer-specific survival (BCSS) and overall survival (OS) compared to those without RT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Huanzuo Yang, Mengxue Qiu, Yu Feng, Nan Wen, Jiao Zhou, Xiangquan Qin, Juan Li, Xinran Liu, Xiaodong Wang, Zhenggui Du
Summary: This study aimed to develop an individualized nomogram to identify early-stage HER2+ patients who could omit radiotherapy after breast-conserving surgery. The results showed that radiotherapy could significantly improve the overall survival and breast cancer-specific survival of HER2+ early-stage breast cancer patients. For high-risk patients, radiotherapy is an essential component of cancer therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Judy C. C. Boughey, Kari M. M. Rosenkranz, Karla V. V. Ballman, Linda McCall, Bruce G. G. Haffty, Laurie W. W. Cuttino, Charlotte S. D. Kubicky, Huong T. T. Le-Petross, Armando E. E. Giuliano, Kimberly J. J. Van Zee, Kelly K. K. Hunt, Olwen M. M. Hahn, Lisa A. A. Carey, Ann H. H. Partridge
Summary: This study is a prospective trial to evaluate the effectiveness of breast-conserving therapy in patients with multiple foci of breast cancer. The results demonstrate that breast-conserving surgery with adjuvant radiation can significantly reduce the 5-year recurrence rate. It suggests that breast-conserving therapy is a reasonable option, especially for patients evaluated with preoperative breast MRI.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jiameng Liu, Zhanlin Zhu, Zhipeng Hua, Weijie Lin, Yiyin Weng, Juli Lin, Hehui Mao, Lifen Lin, Xuming Chen, Jujiang Guo
Summary: The aim of this study is to identify risk factors for refusal of radiotherapy after breast-conserving surgery. The study found that patients with old age, low income, divorce, white race, advanced stage, and no chemotherapy were more likely to refuse radiotherapy.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Yu-Chun Song, Guang-Yi Sun, Hui Fang, Yu Tang, Yong-Wen Song, Chen Hu, Shu-Nan Qi, Bo Chen, Hao Jing, Yuan Tang, Jing Jin, Yue-Ping Liu, Ning-ning Lu, Ye-Xiong Li, Shu-Lian Wang
Summary: This study aimed to compare the quality of life of breast cancer patients after receiving partial breast irradiation (PBI) and whole-breast irradiation (WBI) one year post-treatment. The results showed that both treatments had comparable effects on quality of life within the first year.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Baiyang Fu, Xi Chen, Wenlong Liang, Yao Wang, Yuan Yao, Jianguo Zhang
Summary: This study aimed to establish a nomogram to predict the survival outcome of elderly patients with early breast cancer and compare the prognosis of breast-conserving surgery (BCS) group without postoperative radiotherapy and mastectomy group through risk stratification. The results showed that BCS improved the breast cancer-specific survival of patients in the middle-risk group to some extent.
Review
Oncology
Camille Hardy Abeloos, Juhi M. Purswani, Paulina Galavis, Allison McCarthy, Christine Hitchen, J. Isabelle Choi, Naamit K. Gerber
Summary: Breast re-irradiation (reRT) using external beam radiation is an increasingly popular salvage approach for recurrent or new primary breast cancer after breast-conserving surgery (BCS). However, there are differences in radiation technique, dose, and eligibility criteria among studies. Limited data is available on the efficacy and safety of external beam hypofractionation and accelerated partial-breast irradiation (APBI) regimens. This paper reviews existing data and highlights the need for a randomized controlled trial to better define patient selection for different reRT fractionation regimens.
Article
Oncology
Ying Zhong, Zhe Wang, Yali Xu, Yidong Zhou, Feng Mao, Songjie Shen, Qiang Sun
Summary: This study aimed to assess the safety of breast-conserving surgery without axillary lymph node dissection and radiotherapy in elderly patients with early-stage breast cancer. The results showed that for patients with clinically negative axillary lymph nodes, breast-conserving surgery with radiotherapy is a safe treatment option, and it does not significantly affect distant recurrence-free survival and breast cancer-specific survival compared to mastectomy plus axillary lymph node dissection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Sigaudi, Micol Zannetti, Eleonora Ferrara, Irene Manfredda, Eleonora Mones, Gianfranco Loi, Marco Krengli, Pierfrancesco Franco
Summary: This study reports the early clinical outcomes of a prospective series of early breast cancer patients who received ultra-hypofractionated post-operative whole-breast irradiation after breast-conserving surgery and axillary management. The results show that ultra-hypofractionated WBI provides favorable compliance and early clinical outcomes in early breast cancer after BCS in a real-world setting.
Article
Oncology
Tingting Han, Mingwei Shi, Qiwei Chen, Dongbo Chen, Jiqing Hao
Summary: This study found that adjuvant radiation therapy after breast-conserving surgery can improve both breast cancer-specific survival and overall survival in elderly patients with early-stage breast cancer. The results of subgroup analysis also support this conclusion.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Leqian Guo, Guilan Xie, Ruiqi Wang, Liren Yang, Landi Sun, Mengmeng Xu, Wenfang Yang, Mei Chun Chung
Summary: This study found that for TNBC patients, the survival benefit of breast-conserving surgery with radiotherapy was higher than or similar to that of total mastectomy.