Functional Rescue of Inactivating Mutations of the Human Neurokinin 3 Receptor Using Pharmacological Chaperones

Rescue of cell surface expression and signalling of mutant follicle-stimulating hormone receptors

(2021) Sharika Hanyroup et al.   ENDOCRINOLOGY

Rescue of function of mutant luteinising hormone receptors with deficiencies in cell surface expression, hormone binding and hormone signalling

(2020) Claire Louise Newton et al.   NEUROENDOCRINOLOGY

Tacr3/NK3R: Beyond Their Roles in Reproduction

(2020) Wen-wen Zhang et al.   ACS Chemical Neuroscience

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism

(2017) Kohei Aoyama et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Pharmacological chaperone approaches for rescuing GPCR mutants: Current state, challenges, and screening strategies

(2017) Pieter Beerepoot et al.   PHARMACOLOGICAL RESEARCH

Loss-of-Function Mutations in the Human Luteinizing Hormone Receptor Predominantly Cause Intracellular Retention

(2016) Claire Louise Newton et al.   ENDOCRINOLOGY

Neurokinin B Administration Induces Hot Flushes in Women

(2015) Channa N. Jayasena et al.   Scientific Reports

Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics

(2014) Ya-Xiong Tao et al.   ENDOCRINE REVIEWS

The necessity of and strategies for improving confidence in the accuracy of western blots

(2014) Rajeshwary Ghosh et al.   Expert Review of Proteomics

Using pharmacological chaperones to restore proteostasis

(2014) Ya-Juan Wang et al.   PHARMACOLOGICAL RESEARCH

Pharmacological chaperoning: A primer on mechanism and pharmacology

(2014) Nancy J. Leidenheimer et al.   PHARMACOLOGICAL RESEARCH

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders

(2013) Cintia Tusset et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Regulation of Arcuate Neurons Coexpressing Kisspeptin, Neurokinin B, and Dynorphin by Modulators of Neurokinin 3 and κ-Opioid Receptors in Adult Male Mice

(2013) Kristen A. Ruka et al.   ENDOCRINOLOGY

TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients

(2013) Sekoni D. Noel et al.   FASEB JOURNAL

Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function

(2013) Alfredo Ulloa-Aguirre et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Current and future applications of GnRH, kisspeptin and neurokinin B analogues

(2013) Robert P. Millar et al.   Nature Reviews Endocrinology

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

(2013) J. A. Janovick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications

(2012) Jacques Young et al.   NEUROENDOCRINOLOGY

Molecular Modeling of Neurokinin B and Tachykinin NK3Receptor Complex

(2011) Anjali D. Ganjiwale et al.   Journal of Chemical Information and Modeling

Evidence from the Agonadal Juvenile Male Rhesus Monkey (Macaca mulatta) for the View that the Action of Neurokinin B to Trigger Gonadotropin-Releasing Hormone Release Is Upstream from the Kisspeptin Receptor

(2011) Suresh Ramaswamy et al.   NEUROENDOCRINOLOGY

Normosmic Congenital Hypogonadotropic Hypogonadism Due to TAC3/TACR3 Mutations: Characterization of Neuroendocrine Phenotypes and Novel Mutations

(2011) Bruno Francou et al.   PLoS One

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TAC3/TACR3Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood

(2010) Elena Gianetti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TAC3andTACR3Defects Cause Hypothalamic Congenital Hypogonadotropic Hypogonadism in Humans

(2010) Jacques Young et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting of G protein-coupled receptors to the plasma membrane in health and disease

(2009) Alfredo Ulloa-Aguirre   Frontiers in Bioscience-Landmark

Hypogonadotropic Hypogonadism due to a Novel Missense Mutation in the First Extracellular Loop of the Neurokinin B Receptor

(2009) Tulay Guran et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma Membrane Expression of Gonadotropin-Releasing Hormone Receptors: Regulation by Peptide and Nonpeptide Antagonists

(2009) Ann R. Finch et al.   MOLECULAR ENDOCRINOLOGY

Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine

(2008) Jo Ann Janovick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains

(2008) P. Malherbe et al.   MOLECULAR PHARMACOLOGY

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS