Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality

Ηypercoagulation and myocardial injury as risk factors for mortality in patients with COVID-19 pneumonia

(2021) Nicholas G. Kounis et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Platelet count reduction during in vitro membrane oxygenation affects platelet activation, neutrophil extracellular trap formation and clot stability, but does not prevent clotting

(2021) Patrick Winnersbach et al.   PERFUSION-UK

Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)

(2021) Pascal Urwyler et al.   Trials

Significance of NETs Formation in COVID-19

(2021) Karolina Janiuk et al.   Cells

Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19

(2021) Tanuj Sharma et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Scrutinizing Mechanisms of the ‘Obesity Paradox in Sepsis’: Obesity Is Accompanied by Diminished Formation of Neutrophil Extracellular Traps (NETs) Due to Restricted Neutrophil–Platelet Interactions

(2021) Iwona Cichon et al.   Cells

Immune Response to SARS-CoV-2 Infection in Obesity and T2D: Literature Review

(2021) Jorge Pérez-Galarza et al.   Vaccines

Neutrophil Extracellular Traps in SARS-CoV2 Related Pneumonia in ICU Patients: The NETCOV2 Study

(2021) Mathieu Godement et al.   Frontiers in Medicine

Protective effect of ethyl pyruvate on gut barrier function through regulations of ROS-related NETs formation during sepsis

(2021) Xinyu Wang et al.   MOLECULAR IMMUNOLOGY

Pleiotropic Effects of Tetracyclines in the Management of COVID-19: Emerging Perspectives

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Pharmacology

COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Cardiovascular Medicine

The Looming Effects of Estrogen in Covid-19: A Rocky Rollout

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Nutrition

The potential role of neopterin in Covid-19: a new perspective

(2021) Hayder M. Al-kuraishy et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Covid-19 and development of heart failure: mystery and truth

(2021) Hope Onohuean et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Levamisole Therapy in COVID-19

(2021) Hayder M. Al-kuraishy et al.   VIRAL IMMUNOLOGY

Impact of Sitagliptin in Non-Diabetic Covid-19 Patients

(2021) Hayder M. Al-kuraishy et al.   Current Molecular Pharmacology

The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections

(2021) Mohamed Moubarak et al.   Life-Basel

Niclosamide for Covid-19: bridging the gap

(2021) Hayder M. Al-kuraishy et al.   MOLECULAR BIOLOGY REPORTS

Effects of β-Blockers on the Sympathetic and Cytokines Storms in Covid-19

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Immunology

Maternal Transmission of SARS-CoV-2: Safety of Breastfeeding in Infants Born to Infected Mothers

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Pediatrics

Acute kidney injury and COVID-19

(2021) Hayder M. Al-kuraishy et al.   The Egyptian Journal of Internal Medicine

Thrombomodulin alfa for Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Randomized, Double-blind, Placebo-controlled Trial

(2020) Yasuhiro Kondoh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Vitamin D deficiency 2.0: an update on the current status worldwide

(2020) Karin Amrein et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection

(2020) Carlos H. Hiroki et al.   Frontiers in Immunology

Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis

(2020) Pan Luo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series

(2020) Sigurd F. Lax et al.   ANNALS OF INTERNAL MEDICINE

Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?

(2020) Undurti N. Das   ARCHIVES OF MEDICAL RESEARCH

Severe COVID‐19 infection and thrombotic microangiopathy: success does not come easily

(2020) Eleni Gavriilaki et al.   BRITISH JOURNAL OF HAEMATOLOGY

HMGB1: A Possible Crucial Therapeutic Target for COVID-19?

(2020) Maria Elisabeth Street   Hormone Research in Paediatrics

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypercoagulability of COVID‐19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis

(2020) Mauro Panigada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The versatile heparin in COVID‐19

(2020) Jecko Thachil   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy

(2020) F. Burcu Belen-Apak et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Heparin resistance in COVID-19 patients in the intensive care unit

(2020) D. White et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

A novel peptidylarginine deiminase 4 (PAD4) inhibitor BMS-P5 blocks formation of neutrophil extracellular traps and delays progression of multiple myeloma

(2020) Marina Li et al.   MOLECULAR CANCER THERAPEUTICS

Obesity and its Implications for COVID‐19 Mortality

(2020) William Dietz et al.   Obesity

Cyclosporine therapy in cytokine storm due to coronavirus disease 2019 (COVID-19)

(2020) Erkan Cure et al.   RHEUMATOLOGY INTERNATIONAL

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Heparin as a therapy for COVID-19: current evidence and future possibilities

(2020) Joseph A. Hippensteel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?

(2020) Michael Mazzeffi et al.   ANESTHESIA AND ANALGESIA

C1 esterase inhibitor and the contact system in COVID‐19

(2020) Timothy M. Thomson et al.   BRITISH JOURNAL OF HAEMATOLOGY

SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure

(2020) Alain R. Thierry et al.   CLINICAL SCIENCE

Azithromycin in COVID-19 Patients: Pharmacological Mechanism, Clinical Evidence and Prescribing Guidelines

(2020) Janet Sultana et al.   DRUG SAFETY

What about COVID-19 and arachidonic acid pathway?

(2020) Malvina Hoxha   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis

(2020) Jia-Fu Wei et al.   HEART

Complement Inhibition in Coronavirus Disease (COVID)-19: A Neglected Therapeutic Option

(2020) Philip F. Stahel et al.   Frontiers in Immunology

Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production

(2020) Ravi Holani et al.   Gut Microbes

The complement system in COVID-19: friend and foe?

(2020) Anuja Java et al.   JCI Insight

Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19

(2020) Jonathan H. Chow et al.   ANESTHESIA AND ANALGESIA

Zika virus NS1 affects the junctional integrity of human brain microvascular endothelial cells

(2020) Meghana Rastogi et al.   BIOCHIMIE

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series

(2020) Andrew G. Weber et al.   MOLECULAR MEDICINE

CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes

(2020) Danielle A. S. Rodrigues et al.   PLoS Pathogens

Tempering Macrophage Plasticity for Controlling SARS-CoV-2 Infection for Managing COVID-19 Disease

(2020) Devinder Toor et al.   Frontiers in Pharmacology

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

(2020) Jun Wang et al.   Frontiers in Immunology

Neutrophils in respiratory syncytial virus infection: From harmful effects to therapeutic opportunities

(2020) Alireza Tahamtan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophil extracellular traps exacerbate coagulation and endothelial damage in patients with essential hypertension and hyperhomocysteinemia

(2020) Ji-He Li et al.   THROMBOSIS RESEARCH

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

(2019) Elodie Laridan et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Hyperglycemia Induces Neutrophil Extracellular Traps Formation Through an NADPH Oxidase-Dependent Pathway in Diabetic Retinopathy

(2019) Luoziyi Wang et al.   Frontiers in Immunology

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

(2019) José Perdomo et al.   Nature Communications

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

(2019) Yohei Hisada et al.   HAEMATOLOGICA

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy

(2019) Jean-Louis Vincent et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Excessive Neutrophil Extracellular Trap Formation Aggravates Acute Myocardial Infarction Injury in Apolipoprotein E Deficiency Mice via the ROS-Dependent Pathway

(2019) Zheliang Zhou et al.   Oxidative Medicine and Cellular Longevity

Critical role of neutrophil extracellular traps (NETs) in patients with Behcet’s disease

(2019) Alexandre Le Joncour et al.   ANNALS OF THE RHEUMATIC DISEASES

The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease

(2019) Scott H. Twaddell et al.   CHEST

Prostaglandins in Marine Organisms: A Review

(2019) Federica Di Costanzo et al.   Marine Drugs

Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction

(2019) Kaveh Eghbalzadeh et al.   Frontiers in Immunology

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased plasmatic NETs by-products in patients in severe obesity

(2019) Marco D’Abbondanza et al.   Scientific Reports

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

(2019) Binita Shrestha et al.   Frontiers in Immunology

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

(2019) Jiann-Jyh Lai et al.   IMMUNITY

Complement-coagulation connections

(2018) Edward M. Conway   BLOOD COAGULATION & FIBRINOLYSIS

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

(2018) Brian A. Boone et al.   BMC CANCER

Reduced Variability to Aspirin Antiplatelet Effect by the Coadministration of Statins in High-Risk Patients for Cardiovascular Disease

(2018) Stefania Tacconelli et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Implant delivering hydroxychloroquine attenuates vaginal T lymphocyte activation and inflammation

(2018) Yufei Chen et al.   JOURNAL OF CONTROLLED RELEASE

Clinical Outcomes of Aspirin Interaction with Other Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review

(2018) Zuhair Alqahtani et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Neutrophil extracellular traps prevent HIV infection in the female genital tract

(2018) Fiona D. Barr et al.   Mucosal Immunology

Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms

(2018) Kenneth C. Malcolm et al.   PLoS One

Neutrophil extracellular traps possess anti-human respiratory syncytial virus activity: Possible interaction with the viral F protein

(2018) Priscila Silva Sampaio Souza et al.   VIRUS RESEARCH

The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins

(2018) Vanesa Stojanovska et al.   Frontiers in Cellular Neuroscience

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

Inhibition of Immune Complex Complement Activation and Neutrophil Extracellular Trap Formation by Peptide Inhibitor of Complement C1

(2018) Pamela S. Hair et al.   Frontiers in Immunology

The Lectin Pathway of Complement in Myocardial Ischemia/Reperfusion Injury—Review of Its Significance and the Potential Impact of Therapeutic Interference by C1 Esterase Inhibitor

(2018) Anneza Panagiotou et al.   Frontiers in Immunology

Vitamin D: Nutrient, Hormone, and Immunomodulator

(2018) Francesca Sassi et al.   Nutrients

TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase

(2018) Tingting Gan et al.   Frontiers in Microbiology

Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia

(2018) Shigeo Hanada et al.   Frontiers in Immunology

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy

(2017) Uchini Kosgodage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activated protein C inhibits neutrophil extracellular trap formationin vitroand activationin vivo

(2017) Laura D. Healy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

(2017) Michael J. Kraakman et al.   JOURNAL OF CLINICAL INVESTIGATION

Amplified using DNase I and aptamer/graphene oxide for sensing prostate specific antigen in human serum

(2017) Bi-Yun Fang et al.   SENSORS AND ACTUATORS B-CHEMICAL

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

Neutrophil Extracellular Traps and Endothelial Dysfunction in Atherosclerosis and Thrombosis

(2017) Haozhe Qi et al.   Frontiers in Immunology

Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized double-blind placebo-controlled study

(2017) Ilaria Buondonno et al.   PLoS One

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

(2017) Ingrid Stroo et al.   PLoS One

Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2

(2016) Racquel Domingo-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Different procedures of diphenyleneiodonium chloride addition affect neutrophil extracellular trap formation

(2016) Magdalena Ostafin et al.   ANALYTICAL BIOCHEMISTRY

Neutrophil Extracellular Traps Promote AngiogenesisHighlights

(2016) Lulwah Aldabbous et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hydroxychloroquine in systemic lupus erythematosus (SLE)

(2016) C. Ponticelli et al.   Expert Opinion On Drug Safety

Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation

(2016) Christian C. Yost et al.   JOURNAL OF CLINICAL INVESTIGATION

Aspirin, but Not Tirofiban Displays Protective Effects in Endotoxin Induced Lung Injury

(2016) Jessica Tilgner et al.   PLoS One

Hydroxychloroquine as an anti-thrombotic in antiphospholipid syndrome

(2015) Cristina Belizna   AUTOIMMUNITY REVIEWS

Prostaglandin E2inhibits neutrophil extracellular trap formation through production of cyclic AMP

(2015) Kyosuke Shishikura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arginine-rich histones have strong antiviral activity for influenza A viruses

(2015) Marloes Hoeksema et al.   Innate Immunity

Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils

(2015) Juliana D. B. Rocha et al.   Scientific Reports

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

(2014) Jon Hazeldine et al.   AGING CELL

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aspirin for prevention and treatment of venous thromboembolism

(2014) Cecilia Becattini et al.   BLOOD REVIEWS

β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

(2014) Martin J. Raftery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients

(2014) Seigo Miyoshi et al.   Drug Design Development and Therapy

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury

(2014) Maria Entezari et al.   Redox Biology

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice

(2013) Rui Kang et al.   GASTROENTEROLOGY

Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients

(2013) Emilie Tourneur et al.   PLoS Pathogens

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications

(2010) S. Kanoh et al.   CLINICAL MICROBIOLOGY REVIEWS

Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) in the Treatment of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-Analysis

(2010) Kentaro Iwata et al.   INTERNAL MEDICINE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Pathology of the swine-origin influenza A (H1N1) flu

(2010) E.E. Calore et al.   PATHOLOGY RESEARCH AND PRACTICE

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

(2009) C. C. Yost et al.   BLOOD

Activation of the Human Contact System on Neutrophil Extracellular Traps

(2009) Sonja Oehmcke et al.   Journal of Innate Immunity

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA