The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

(2021) Jan Budczies et al.   OncoImmunology

Familial Burden and Other Clinical Factors Associated With Various Types of Cancer in Individuals With Lynch Syndrome

(2021) Leah H. Biller et al.   GASTROENTEROLOGY

DNA Mismatch Repair Deficient Non‐Neoplastic Endometrial Glands Are Common in Lynch Syndrome Patients and Are Present at a Higher Density Compared to the Colon

(2021) Shaymaa Hegazy et al.   HISTOPATHOLOGY

The coding microsatellite mutation profile of PMS2-deficient colorectal cancer

(2021) Sanne W. Bajwa - ten Broeke et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

(2021) Johannes Gebert et al.   GASTROENTEROLOGY

Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients

(2020) Randall E. Brand et al.   Familial Cancer

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome

(2020) Christoph Engel et al.   GASTROENTEROLOGY

Spontaneous regression of mismatch repair deficient colorectal cancers: a case series

(2020) Takahiro Utsumi et al.   Digestive Endoscopy

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

(2020) Alireza Labani-Motlagh et al.   Frontiers in Immunology

A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical Trial

(2020) Matthias Kloor et al.   CLINICAL CANCER RESEARCH

Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa

(2020) Laura Reyes-Uribe et al.   GUT

Immune suppression in gliomas

(2020) Matthew M. Grabowski et al.   JOURNAL OF NEURO-ONCOLOGY

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

(2020) John Burn et al.   LANCET

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer

(2020) Bernhard Mlecnik et al.   JOURNAL OF CLINICAL ONCOLOGY

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

(2020) Alexej Ballhausen et al.   Nature Communications

Tumor Mutational Burden as a Predictor of Immunotherapy Response: Is More Always Better?

(2020) John H. Strickler et al.   CLINICAL CANCER RESEARCH

Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review

(2019) Nozomi Karakuchi et al.   World Journal of Surgical Oncology

High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer

(2019) Pauline L. Pfuderer et al.   BRITISH JOURNAL OF CANCER

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

(2019) Mev Dominguez-Valentin et al.   GENETICS IN MEDICINE

Precision Treatment and Prevention of Colorectal Cancer—Hope or Hype?

(2019) Charles Muller et al.   GASTROENTEROLOGY

Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGF β

(2019) Markus Germann et al.   EMBO Molecular Medicine

The Intestinal Microbiota in Colorectal Cancer

(2018) Herbert Tilg et al.   CANCER CELL

DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome

(2018) Rish K. Pai et al.   MODERN PATHOLOGY

The gut microbiota influences anticancer immunosurveillance and general health

(2018) Bertrand Routy et al.   Nature Reviews Clinical Oncology

Complex pattern of immune evasion in MSI colorectal cancer

(2018) Mine Ozcan et al.   OncoImmunology

International society for gastrointestinal hereditary tumours—InSiGHT

(2017)   Familial Cancer

Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas

(2017) Mark Clendenning et al.   Familial Cancer

Cancer risk and survival inpath_MMRcarriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

(2017) Pål Møller et al.   GUT

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome

(2017) Hans Binder et al.   JOURNAL OF PATHOLOGY

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer

(2017) Jonas Janikovits et al.   OncoImmunology

Gene expression markers of Tumor Infiltrating Leukocytes

(2017) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Gut Microbiota, Inflammation, and Colorectal Cancer

(2016) Caitlin A. Brennan et al.   Annual Review of Microbiology

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

(2016) Pål Møller et al.   GUT

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

(2016) Bernhard Mlecnik et al.   IMMUNITY

Reverse immunoediting: When immunity is edited by antigen

(2016) Anna Merlo et al.   IMMUNOLOGY LETTERS

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer

(2015) Fabian Echterdiek et al.   OncoImmunology

Fusobacterium nucleatumand T Cells in Colorectal Carcinoma

(2015) Kosuke Mima et al.   JAMA Oncology

Cancer Risks forMLH1andMSH2Mutation Carriers

(2012) James G. Dowty et al.   HUMAN MUTATION

Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study

(2012) Matthias Kloor et al.   LANCET ONCOLOGY

HIV Infection, Immunodeficiency, Viral Replication, and the Risk of Cancer

(2011) M. J. Silverberg et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology

(2009) Stefan M. Woerner et al.   NUCLEIC ACIDS RESEARCH

Fas Ligand Expression in Lynch Syndrome-Associated Colorectal Tumours

(2009) Jan J. Koornstra et al.   PATHOLOGY & ONCOLOGY RESEARCH

Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers

(2008) Yvette Schwitalle et al.   GASTROENTEROLOGY