Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

(2021) Prashant V. Bommi et al.   CANCER RESEARCH

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche

(2020) Manolis Roulis et al.   NATURE

A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical Trial

(2020) Matthias Kloor et al.   CLINICAL CANCER RESEARCH

Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa

(2020) Laura Reyes-Uribe et al.   GUT

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

(2020) John Burn et al.   LANCET

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

The Age of Cyclic Dinucleotide Vaccine Adjuvants

(2020) Himanshu Gogoi et al.   Vaccines

Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

(2019) Rajarsi Mandal et al.   SCIENCE

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

(2019) Sean K. Maynard et al.   BMC CANCER

Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome

(2018) Kyle Chang et al.   JAMA Oncology

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

(2018) John J. McNeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

(2018) Alicia Latham et al.   JOURNAL OF CLINICAL ONCOLOGY

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Cancer risk and survival inpath_MMRcarriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

(2017) Pål Møller et al.   GUT

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2

(2017) Sigurdis Haraldsdottir et al.   Nature Communications

Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention

(2017) Juana Martín-López et al.   Oncotarget

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer

(2016) Aung Ko Win et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients

(2016) Satoru Iwasa et al.   CANCER SCIENCE

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

Sumoylation regulates EXO1 stability and processing of DNA damage

(2015) Serena Bologna et al.   CELL CYCLE

Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors

(2014) Stefan M. Woerner et al.   MOLECULAR CARCINOGENESIS

Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells

(2014) Elena Tosti et al.   Genome Medicine

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

(2013) Yared Hailemichael et al.   NATURE MEDICINE

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

(2011) John Burn et al.   LANCET

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

(2009) Melanie H. Kucherlapati et al.   GASTROENTEROLOGY

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology

(2009) Stefan M. Woerner et al.   NUCLEIC ACIDS RESEARCH

Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers

(2008) Yvette Schwitalle et al.   GASTROENTEROLOGY