Article
Agriculture, Dairy & Animal Science
Xin-Xin Liu, Hong-Yun Zhang, Xin Song, Ying Yang, Zhi-Qiang Xiong, Yong-Jun Xia, Lian-Zhong Ai
Summary: The study found that the CLA biotransformation abilities of different Lactobacillus plantarum strains significantly depended on the transcriptional maintenance of cla-hy, cla-dh, and cla-dc. A high transcriptional level in the exponential phase did not necessarily lead to high CLA production, and there was a correlation between CLA production and increased levels of cla-hy transcription.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Patryk Zdziobek, Grzegorz Stefan Jodlowski, Edyta Aneta Strzelec
Summary: The concentration of polyphenols, lactic acid, and antioxidant properties increased more at 30 degrees C than at 35 degrees C during the lactic fermentation process in butanol extract and broccoli juice. The fermented juice exhibited the ability to reduce free radicals and had high total antioxidant capacity. Lactic acid concentration, total flavonoid content, and acidity increased during the fermentation process in broccoli juice. The use of Lactiplantibacillus plantarum showed beneficial effects on health and the human body.
Article
Biotechnology & Applied Microbiology
Tamara Stela Mendonca Azevedo, Lavinia Kelly Barros Silva, Alvaro Silva Lima, Matheus Mendonca Pereira, Elton Franceschi, Cleide Mara Faria Soares
Summary: This study conducted a computational analysis on the biotransformation of alpha-tocopherol into tocopherol esters, observing the tunnels in enzymatic structures and the energies related to molecule transport. Results revealed variations in the quantity of tunnels in different lipases, with CALB identified as the enzyme most likely to transport substrates during alpha-tocopherol biotransformation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Haocheng Liu, Yuqian Tang, Zhaowen Deng, Jiguo Yang, Dan Gan
Summary: A process for transforming litchis' polymeric proanthocyanidins (LPPCs) using Lactobacilli has been established to enhance their antioxidative properties. Lactobacillus plantarum was used to enhance the transformation effect, achieving a transformation rate of 78.36%. The products showed significantly higher in vitro antioxidative activity compared to LOPCs and LPPCs, with a scavenging activity for DPPH free radicals that was 1.71 times higher than LOPCs, and a rate of inhibiting CD-POV that was 2.0 times higher than LPPCs.
Review
Biotechnology & Applied Microbiology
Leila Maidana, Marielen de Souza, Ana Paula F. R. L. Bracarense
Summary: Mycotoxins are toxic metabolites produced by fungi that contaminate animal feeds, causing economic losses due to direct effects on animal health and rejection of contaminated grains. L. plantarum, a lactic acid bacteria, has shown promise in reducing DON levels and toxicity through inhibition of fungal growth, adsorption, and biotransformation.
JOURNAL OF FOOD PROTECTION
(2022)
Article
Biochemistry & Molecular Biology
Duaa Eliwa, Mohamed A. Albadry, Abdel-Rahim S. Ibrahim, Amal Kabbash, Kumudini Meepagala, Ikhlas A. Khan, Mona El-Aasr, Samir A. Ross
Summary: This study identified various metabolites of papaverine produced by four different fungi, including two new metabolites. The structures of these metabolites were elucidated using NMR and HRMS, and some of them showed better binding properties in docking studies compared to papaverine.
Article
Chemistry, Multidisciplinary
Houefa Egidia Fallon Adido, Cristian Kallahan Silva Chagas, Gleison Goncalves Ferreira, Mirian Leticia Carmo Bastos, Maria Fani Dolabela
Summary: As life expectancy increases, the number of people affected by cancer is increasing. This study evaluated the antitumor potential of acetogenins isolated from Annona muricata. The results showed that muricatacin and cis-uvariamicin IV have promising antitumor activity.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gleison Goncalves Ferreira, Ana Carolina Sousa Quaresma, Dayse Lucia do Nascimento Brandao, Andrey Moacir do Rosario Marinho, Jose Edson de Sousa Siqueira, Kamila Leal Correa, Jose Otavio Carrera Silva-Junior, Sandro Percario, Maria Fani Dolabela
Summary: This study evaluated the toxic behavior of an extract and fraction rich in acetogenins from Annona muricata seeds and studied the acetogenin, Annonacin, in silico. The results showed that the extract and fraction exhibited genotoxic activity against plant cells and produced negative effects on the cells. Additionally, Annonacin effectively linked to complex I and presented different toxicity activities, highlighting its potential as an anticancer agent.
Article
Microbiology
Xin-Xin Liu, Lei Liu, Xin Song, Guang-Qiang Wang, Zhi-Qiang Xiong, Yong-Jun Xia, Lian-Zhong Ai
Summary: CLA (conjugated linoleic acid) has important physiological functions and has attracted extensive attention. CLA from natural sources cannot meet the demand. This study revealed the underlying transcriptional regulation mechanism of CLA biotransformation in Lactiplantibacillus plantarum. The transcriptional regulator ArgR(2) was identified to play a role in regulating the production of CLA. This finding expands our knowledge of CLA biosynthesis regulation and provides theoretical foundations for its production and application.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Applied
Ahmet Furkan Caglar, Ayse Gulden Goksu, Bilal Cakir, Ibrahim Gulseren
Summary: Cold press technology can produce high quality oil products and stable oilseed cakes, with hazelnut cakes being a potential source of antidiabetic peptides. By extracting and fractionating hazelnut peptides, it was found that some exhibited moderate DPP-IV inhibitory activity, suggesting their potential as antidiabetic agents.
Article
Plant Sciences
Florina Stoica, Iuliana Aprodu, Elena Enachi, Nicoleta Stanciuc, Nina Nicoleta Condurache, Denisa Eglantina Duta, Gabriela Elena Bahrim, Gabriela Rapeanu
Summary: This study identified eight anthocyanins in red onion skins extract, with thermal stability decreasing and degradation rate increasing as temperature rises. The extract exhibited inhibitory activity on enzymes related to metabolic syndrome, oxidative stress, and inflammatory process diseases, making it suitable for multiple applications.
Article
Biotechnology & Applied Microbiology
Hla Myo, Nara Nantarat, Nuntawat Khat-Udomkiri
Summary: The use of biotransformation with Lactic Acid Bacteria on coffee pulp can enhance its antioxidant properties and potential health benefits.
FERMENTATION-BASEL
(2021)
Article
Plant Sciences
Samik Hazra, Anindya Sundar Ray, Swetarka Das, Arunava Das Gupta, Chowdhury Habibur Rahaman
Summary: This study investigated the chemical composition, antioxidant, anti-inflammatory, and antidiabetic activities of the phenolic extract of Causonis trifolia shoot (PECTS). The results showed that PECTS was rich in phenolics, flavonoids, tannins, and alkaloids, and exhibited significant antioxidant, anti-inflammatory, and antidiabetic properties. Molecular docking and computational modeling identified one compound (ergosta-5,22-dien-3-ol, acetate, (3 beta,22E)) with strong binding affinity to target proteins involved in these activities. The optimized extract showed no toxicity in cell and animal studies. These findings provide a foundation for the development of novel drugs using C. trifolia.
Article
Biochemistry & Molecular Biology
Brendan P. Norman, Andrew S. Davison, Juliette H. Hughes, Hazel Sutherland, Peter JM. Wilson, Neil G. Berry, Andrew T. Hughes, Anna M. Milan, Jonathan C. Jarvis, Norman B. Roberts, Lakshminarayan R. Ranganath, George Bou-Gharios, James A. Gallagher
Summary: This study conducted a metabolomic analysis of AKU disease and identified the metabolic effects of HGD deletion. The findings provide insights into the overall tyrosine metabolism and discovered previously unknown pathways. This research contributes to a better understanding and potential treatment options for AKU disease.
Article
Food Science & Technology
Xiaozhe Yang, Wenzhong Hu, Zhilong Xiu, Yaru Ji, Yuge Guan
Summary: This study investigated the interaction between Leu. mesenteroides and L. plantarum during single and mixed-culture fermentation of Chinese northeast sauerkraut using metabolomics and transcriptomics analysis. The results showed that the mixed culture had different metabolite profiles compared to the single culture. Carbohydrate metabolism was found to be the most influenced pathway, with significant differences in gene expression between the mixed and single cultures.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yucheng Zou, Aiping Zhang, Lin Lin, Sobhy Ahmed El-Sohaimy, Yang Li, Liangru Wu, Hui Zhang
Summary: Recently, biopolymer-based structured oil has been developed as a substitute for saturated and trans-fats. In this study, porous biopolymeric networks were created using cross-linked dialdehyde cellulose (DAC) and gelatin to prepare oleogels. The cross-linking between DAC and gelatin resulted in a porous three-dimensional network structure with enhanced thermal stability, mechanical properties, and water stability. The DG oleogels showed excellent oil absorption and oil holding capacities, and exhibited antibacterial activities against Escherichia coli and Staphylococcus aureus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Hina Rehman, Waqar Ali, Nadir Zaman Khan, Muhammad Aasim, Tariq Khan, Ayaz Ali Khan
Summary: This study reports the phyto-fabrication of ZnO-NPs mediated by Delphinium uncinatum root extract, and their various biological activities such as antioxidant, antimicrobial, antidiabetic, cytotoxic, anti-inflammatory, and anti-aging effects were investigated. With such diverse biological potentials, ZnO-NPs can be a potent weapon against a plethora of diseases, though further research is needed to understand the precise mechanism of their biological potency.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Xinxia Wang, Zaitian Wang, Zhilan Sun, Daoying Wang, Fang Liu, Lin Lin
Summary: This paper investigates the spoilage bacteria in chilled chicken and finds that different species of bacteria display different psychrotrophic spoilage characteristics. Among the six evaluated bacteria, Pseudomonas lundensis J8 exhibits the strongest spoilage potential in situ. The volatile flavor analysis indicates that the characteristic odors representing spoilage increase during storage and are correlated with the protease activity of bacteria in vitro.
Review
Biochemistry & Molecular Biology
Tariq Aziz, Abad Ali Nadeem, Abid Sarwar, Ishrat Perveen, Nageen Hussain, Ayaz Ali Khan, Zubaida Daudzai, Haiying Cui, Lin Lin
Summary: This review primarily focuses on the genetics, physical parameters, and the use of nanoparticles as delivery systems for drugs and vaccines via the nasal cavity in the aging process. Various genes, including VEGF and FOLR1, have been found to play significant roles in angiogenesis, cellular regeneration, and healthy aging.
Article
Biotechnology & Applied Microbiology
Muhammad Naveed, Muhammad Aqib Shabbir, Noor-ul Ain, Khushbakht Javed, Sarmad Mahmood, Tariq Aziz, Ayaz Ali Khan, Ghulam Nabi, Muhammad Shahzad, Mousa Essa Alharbi, Metab Alharbi, Abdulrahman Alshammari
Summary: The unexpected outbreak of monkeypox virus in 2022 has led researchers to focus on potential therapeutic approaches. This study used computational engineering to screen random antiviral compounds against the virulent protein MPXVgp169, and also modified toxic chains or atoms for enhanced efficacy. The chain-engineered dolutegravir showed promising results as a potential therapeutic strategy for monkeypox infection.
BIOENGINEERING-BASEL
(2023)
Article
Microbiology
Tariq Aziz, Muhammad Naveed, Khizra Jabeen, Muhammad Aqib Shabbir, Abid Sarwar, Yang Zhennai, Metab Alharbi, Abdulrahman Alshammari, Abdullah F. F. Alasmari
Summary: The comparative genomic analysis of Lactiplantibacillus plantarum YW11 isolated from Tibetan kefir reveals that its genome consists of a circular single chromosome with a G + C content of 43.2%. Through comparison with other closely related strains, it is found that L. plantarum YW11 shares a significant portion of its gene content with L. plantarum C11 and L. plantarum LMG21703. The analysis also shows that L. plantarum YW11 exhibits resistance against various pathogens and has excellent aerotolerance, making it useful for industrial applications.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Tariq Aziz, Muhammad Naveed, Muhammad Aqib Shabbir, Abid Sarwar, Ayaz Ali Khan, Yang Zhennai, Metab Alharbi, Abdulrahman Alsahammari, Abdullah F. Alasmari
Summary: This study conducted a comprehensive analysis of the Lactiplantibacillus plantarum K25 strain's genetic makeup through comparative genomics. The genome exhibited high efficiency and compactness, with 3,199 protein-encoding genes and a GC content of 43.38%. The study elucidated the evolutionary lineage of Lactiplantibacillus plantarum strains and identified various genetic components with potential applications in biotechnology and medicine.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xiaochen Chen, Jinming Dai, Mei Bai, Haiying Cui, Lin Lin
Summary: In this study, visible light-driven photocatalytic active composite nanofibers were synthesized by loading nonthermal nitrogen plasma-treated graphite carbon nitride (g-C3N4) onto poly(ethylene oxide) nanofibers. The nanofibers showed the highest photodegradation rate of omethoate when the carbon nitride loading amount was 0.5%. The high-power nonthermal nitrogen plasma treatment did not significantly affect the chemical structure of g-C3N4 but changed the abundance of its surface reactive sites, leading to a significant improvement in its photocatalytic activity. The research discusses possible photocatalytic mechanisms and enhances the application potential of g-C3N4 in pesticide degradation.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Naveed, Sarmad Mahmood, Tariq Aziz, Muhammad Hammad Arif, Urooj Ali, Faisal Nouroz, Christos Zacharis, Metab Alharbi, Abdulrahman Alshammari, Abdullah F. Alasmari
Summary: This study proposes an mRNA-based vaccine candidate against the Nipah virus using a reverse-vaccinology approach and immunoinformatics. The candidate shows high antigenicity, structural stability, and the ability to induce a prompt and stable immune response. It has the potential to eliminate the virus from the body and serves as a foundation for future trials.
ACTA BIOCHIMICA POLONICA
(2023)
Article
Biotechnology & Applied Microbiology
Zhihui Li, Tian-tian Lai, Tariq Aziz, Zhang Min, Abid Sarwar, Yang Zhennai, Metab Alharbi, Abdulrahman Alshammari, Abdullah F. Alasmari
Summary: This study successfully purified galacto-oligosaccharide (GOS) using a yeast fermentation method and investigated the interaction between GOS and casein. The results showed that higher concentrations of GOS in the GOS/casein complexes increased their viscoelasticity and water-holding capacity, but decreased their hardness, elasticity, and cohesiveness at a certain concentration. Addition of GOS to casein suspension significantly reduced the particle size of the formed complexes and improved the stability of the suspension system.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Shaoli Liu, Ting Lei, Guipu Li, Shuming Liu, Xiaojun Chu, Donghai Hao, Gongnian Xiao, Ayaz Ali Khan, Taqweem Ul Haq, Manal Y. Sameeh, Tariq Aziz, Manal Tashkandi, Guanghua He
Summary: In this study, four methods were employed to preprocess the original spectra of infant formula milk powder, and two algorithms were used to extract characteristic wavelengths. PLSR and SVR models were established to predict the contents of micronutrient components. The results showed that the preprocessing methods and algorithms were effective in extracting feature wavelengths and achieving accurate predictions. This study is important for online detection and optimization control of nutritional components in infant formula production.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Naveed, Imran Ali, Tariq Aziz, Nouman Ali, Ali Hassan, Shafiq Ur Rahman, Riffat Aziz, Metab Alharbi
Summary: This research analyzed the medicinal plant Melia azedarach and identified potential drug candidates against tuberculosis. The study also characterized a hypothetical protein in Mycobacterium tuberculosis. The compounds found in Melia azedarach have the potential for pharmacological applications.
JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Applied
Xueli Zhang, Xiaochen Chen, Jinming Dai, Haiying Cui, Lin Lin
Summary: The effects of boiling water treatments on the properties of dragon fruit peel pectin films were investigated in this study. It was found that boiling water treatment significantly impacted the mechanical, color, microstructure, and antioxidant capacity of the films, while the barrier, water sensitivity, and thermal stability were hardly affected.
FOOD HYDROCOLLOIDS
(2024)
Article
Biochemistry & Molecular Biology
Muhammad Naveed, Muhammad Aqib Shabbir, Tariq Aziz, Hafiz Muhammad Hurraira, Sayyeda Fatima Zaidi, Ramsha Athar, Hassan Anwer Chattha, Metab Alharbi, Abdulrahman Alsahammari, Abdullah F. Alasmari
Summary: Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder, currently lacks a cure. CRISPR-Cas9 genome editing technology shows promise as a potential treatment for ALS.
ACTA BIOCHIMICA POLONICA
(2023)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)