Article
Chemistry, Multidisciplinary
Jian Dong, Kai-Jia Zhang, Gao-Cai Li, Xing-Ren Chen, Jia-Jia Lin, Jia-Wei Li, Zhong-Yang Lv, Zhao-Zhi Deng, Jin Dai, Wangsen Cao, Qing Jiang
Summary: The synthetic triterpenoid compound CDDO-Im has been identified to exhibit prominent chondroprotective and anti-osteoarthritis (OA) activities by inhibiting chondrocyte apoptosis and cartilage degradation. It effectively reduces knee joint cartilage erosion and inflammatory cytokine levels in a mouse OA model, mainly through Nrf2 activation and enhancement of autophagy activities.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Xiaoli Hou, Huanhuan Liu, Yukun Ping, Feng Zhang, Lingyun Zhi, Xinhui Jiang, Fuping Zhang, Cai Song, Zhaohui Zhang, Jinggui Song
Summary: The study found that CDDO-Im treatment significantly improved depressive behaviors in PSD rats and reduced neuronal loss in the hippocampus. This treatment alleviated oxidative stress and inflammatory response in PSD rats by regulating the Nrf2/ARE pathway.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eiki Yoshida, Shimon Sakaguchi, Masayuki Yamamoto
Summary: Activation of Nrf2 improves arthritis in SKG mice by inhibiting pro-inflammatory cytokines and inducing antioxidant enzymes, suggesting it as a new therapeutic strategy for rheumatoid arthritis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Juan Zhang, Jing Liu, Jing-Wen Liu, Qi-Meng Zhu, Min Zhang, Rui Zhang, Xiao-Chi Ma, Xia Lv, Zhen-Long Yu, Cheng-Peng Sun
Summary: This study aimed to explore the anti-inflammatory and anti-oxidation effects of Inulae Herba (IH) and its underlying mechanism for treating acute lung injury (ALI).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Cell Biology
Bryan J. Mathis, Hideyuki Kato, Yuji Hiramatsu
Summary: Nrf2 is a key regulator of the antioxidant response and detoxification of xenobiotics. However, excessive upregulation of Nrf2 may lead to cardiomyopathy, and miRNA involvement adds complexity to this mechanism. Extensive research has been done on exogenous compounds that regulate Nrf2 and their potential to promote cardiomyopathy, as well as their comparison to exercise-induced factors.
Article
Integrative & Complementary Medicine
Miao Lin, Weixi Xie, Dayan Xiong, Siyuan Tang, Xiaoting Huang, Lang Deng, Lei Huang, Xiaohua Zhang, Tingting Zhou, Rui Qian, Qian Zeng, Xiaoxue Sang, Yuyang Luo, Qingzhong Hua, Lu Ren, Wei Liu
Summary: The study found that cyasterone can defend against sepsis-induced acute lung injury (ALI) by inhibiting inflammatory responses and oxidative stress, which depends on the upregulation of the Nrf2 pathway through phosphorylation of AKT(Ser473)/GSK3 beta(Ser9).
Article
Pharmacology & Pharmacy
Yueguo Wang, Wenwen Wang, Shusheng Zhou, Yulan Wang, Obed Cudjoe, Yu Cha, Chunyan Wang, Xiaoguang Cao, Wei Liu, Kui Jin
Summary: Our study found that Poldip2 knockdown alleviates LPS-induced acute lung injury (ALI) by inhibiting the Nox4/Nrf2/NF-κB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ya-xian Wu, Ying-ying Wang, Zhi-qi Gao, Dan Chen, Gang Liu, Bin-bin Wan, Feng-juan Jiang, Ming-xia Wei, Jing Zuo, Jun Zhu, Yong-quan Chen, Feng Qian, Qing-feng Pang
Summary: Ethyl ferulate (EF) ameliorates LPS-induced acute lung injury (ALI) by activating the AMPK/Nrf2 pathway, reducing inflammation. The study provides a basis for developing EF as an anti-inflammatory agent for ALI/ARDS therapy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Jessica A. Moerland, Ana S. Leal, Beth Lockwood, Elena Y. Demireva, Huirong Xie, Teresa Krieger-Burke, Karen T. Liby
Summary: The NRF2/KEAP1 pathway protects healthy cells and maintains cellular homeostasis. Activating NRF2 improves the phenotype of tumor-educated macrophages and reduces tumor burden, but this effect is dependent on Nrf2 expression. Nrf2 knockout exacerbates lung tumorigenesis and impairs the anti-cancer effect of macrophages, while the NRF2 activator CDDO-Me promotes an Nrf2-dependent, anti-cancer macrophage phenotype.
Article
Immunology
Ting-Ting Yao, Yan Zhang, Rong-Ling He, Xin Lv, Yi-Jun He, Meng -Yu Li, Yuan-Yuan Han, Ling-Zhi Long, Guo-Liang Jiang, Xiao-Yun Cheng, Gao-Yun Hu, Qian-Bin Li, Li-Jian Tao, Jie Meng
Summary: Mefunidone effectively protects against lipopolysaccharide-induced acute lung injury by inhibiting the MAPK signaling pathway and activating the Nrf2 pathway, thereby alleviating inflammation and oxidative stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lianxiang Luo, Fangfang Huang, Saiyi Zhong, Rui Ding, Jiating Su, Xiaoling Li
Summary: In this study, it was found that astaxanthin can inhibit inflammation and ferroptosis by regulating the Keap1-Nrf2/HO-1 pathway, thereby reducing the occurrence and development of LPS-induced ALI.
Article
Plant Sciences
Huanwu Hong, Siyue Lou, Fanli Zheng, Hang Gao, Nina Wang, Shasha Tian, Guozheng Huang, Huajun Zhao
Summary: The study demonstrates that Hydnocarpin D (HD) can protect against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting oxidative stress and inflammation. This protective effect may be mediated through the regulation of MAPK/NF-kappa B and Keap1/Nrf2/HO-1 signaling pathways.
Article
Cell Biology
Lingming Kong, Jie Deng, Xiang Zhou, Binbin Cai, Baofu Zhang, Xiaohu Chen, Zongjing Chen, Weiming Wang
Summary: This study demonstrates that SIT reduces oxidative stress and excessive autophagy in SAP-ALI through the p62-Keap1-Nrf2 signaling pathway and nuclear translocation of Nrf2. However, the anti-inflammatory effect of SIT is reduced in Nrf2 knockout mice and Nrf2-knockdown BEAS-2B cells, leading to ROS accumulation and excessive autophagy.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Le Zhang, Lijuan Xu, Haihu Chen, Wannian Zhang, Chengguo Xing, Zhuo Qu, Jianqiang Yu, Chunlin Zhuang
Summary: A series of novel compounds were designed to reduce oxidative stress and inflammation by inhibiting the Keap1-Nrf2 pathway, with SCN-16 showing promising activity. In cell experiments and animal models, SCN-16 demonstrated superior effects in reducing inflammation and lung injuries compared to existing compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)