Article
Health Care Sciences & Services
Senthilraj Retinasekharan, Norasnieda Md Shukri, Ahmad Filza Ismail, Baharudin Abdullah
Summary: A new questionnaire was developed and validated to assess the knowledge, attitude, and practice of allergic rhinitis patients using intranasal corticosteroids. The questionnaire consists of 3 domains with 12 items and has demonstrated validity and reliability, making it a useful tool to improve patient treatment by understanding compliance factors.
Article
Pharmacology & Pharmacy
Prempreet Kaur Manjit Singh, Elang Kumaran Krishnan, Norhafiza Mat Lazim, Najib Majdi Yaacob, Baharudin Abdullah
Summary: The study found that medication adherence to intranasal corticosteroid spray among allergic rhinitis patients is associated with severe nasal symptoms, allergen sensitization, and elevated total serum IgE levels. Multiple medication use had no impact on adherence. Lack of symptoms was a significant barrier to adherence, highlighting the need to emphasize the benefits of using the prescribed dose and frequency of intranasal corticosteroid spray to patients with mild and moderate allergic rhinitis.
Article
Pharmacology & Pharmacy
S. Ulusoy, N. Bayar Muluk, G. K. Scadding, G. S. Passali, M. Dilber, P. Gevaert, D. Passali, A. S. Resuli, L. van Gerven, L. Kalogjera, E. Prokopakis, P. Rombaux, P. Hellings, C. Cingi
Summary: This paper reviews the intranasal trigeminal system and its associated reflexes, emphasizing their importance in human health and disease, particularly in rhinitis. The intranasal trigeminal system provides sensory perception and responds to chemical signals, supplying information about the nasal airway. The known reflexes within this system play a vital role in human physiology.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Otorhinolaryngology
Kachorn Seresirikachorn, Joaquim Mullol, Kanda Limitlaohaphan, Vararuthai Asvapoositkul, Kornkiat Snidvongs
Summary: The combination of INCS and LTRA showed no difference compared to INCS in monotherapy in improving nasal symptoms and patient's quality of life, but may be more effective in improving ocular symptoms.
Article
Allergy
Virginia Hernandez Santiago, Adeniyi Francis Fagbamigbe, Frank M. Sullivan, Utkarsh Agrawal, Daniel Morales, Colin Mccowan, Brian Lipworth
Summary: This study found that exposure to intranasal corticosteroids (INCS) is not significantly associated with COVID-19 mortality. However, the use of INCS is significantly associated with a lower all-cause mortality among different patient groups.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Allergy
Huadong Xu, Nobutaka Ohgami, Masafumi Sakashita, Kazuhiro Ogi, Kazunori Hashimoto, Akira Tazaki, Keming Tong, Masayo Aoki, Shigeharu Fujieda, Masashi Kato
Summary: The study found that the level of Pb in the nasal epithelial lining fluid of allergic patients was higher compared to the control group, and it was positively correlated with pollen counts and subjective symptoms. Using a mouse model, it was confirmed that Pb exacerbates allergic symptoms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Baoshi Fan, Haiqian Jia, Hui Yu, Yaoke Xu, Rui Li, Jikuan Qiu, Jiayue Wang, Xizi Wan, Junxiu Liu
Summary: Allergic rhinitis is a global health problem, and oral/intranasal administration of H-1-antihistamines and corticosteroids is the main therapeutic method. However, the low local bioavailability of drugs hinders effective treatment. Recently, a hydrogel-based intranasal delivery system (HIDS) has emerged as a promising strategy to extend drug residence time. This review discusses the designs, therapeutic effects, and future prospects of HIDS for allergic rhinitis treatment.
ADVANCED THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Antonio Moffa, Lucrezia Giorgi, Luca Carnuccio, Rodolfo Lugo, Peter Baptista, Manuele Casale
Summary: This study aimed to compare the efficacy of Beclomethasone Dipropionate (BDP) delivered via Spray-sol with nasal spray in allergic rhinitis (AR) patients. The results showed that BDP delivered with Spray-sol was more effective in reducing nasal symptoms and inflammation compared to nasal spray. These findings suggest the potential application of BDP nasal solution in the treatment of AR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Erhan Arslan, Kamil Gokce Tulaci, Hasan Canakci, Seda Arslan, Hasmet Yazici
Summary: The study found that intranasal steroid treatment was more successful in reducing adenoid/choana ratio in patients with adenoid tissue hypertrophy (ATH) without allergic rhinitis (AR). Additionally, the presence of allergic rhinitis played a significant role in predicting treatment success when considering intranasal steroid treatment for ATH.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Review
Otorhinolaryngology
Minh P. Hoang, Wirach Chitsuthipakorn, Kachorn Seresirikachorn, Kornkiat Snidvongs
Summary: Regular use of intranasal corticosteroid spray is more effective than as-needed use for improving symptoms and quality of life in patients with allergic rhinitis, but as-needed use shows better results compared to as-needed antihistamine and placebo. Therefore, as-needed intranasal corticosteroid spray has some value in the treatment of allergic rhinitis.
Review
Immunology
Chao Luo, Shunlin Peng, Mao Li, Xudong Ao, Zhiqing Liu
Summary: Probiotic supplements are effective in relieving symptoms of allergic rhinitis and improving the quality of life, but there is high heterogeneity in some results.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zao Ji, Feifei Jiang
Summary: This study systematically evaluated the clinical efficacy and safety of sublingual immunotherapy for allergic rhinitis. The findings showed that sublingual immunotherapy has better efficacy and safety compared to traditional medicine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
David C. Griffith, Elizabeth E. Morgan, Michael N. Dudley, Jeffery S. Loutit
Summary: The study showed that Biapenem exposure increased slightly more than dose proportionally after multiple doses, with no evidence of accumulation. Urinary recovery ranged from 14.2% at 250 mg to 42.3% at 1,250 mg. Biapenem was well tolerated up to 1,000 mg doses every 8 hours, but higher incidences of nausea, vomiting, and rash were reported at 1,250 mg.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Rezika Mohammed, Mezgebu Silamsaw Asres, Esayas Kebede Gudina, Wondimagegn Adissu, Hilary Johnstone, Anne Claire Marrast, Cristina Donini, Stephan Duparc, Daniel Yilma
Summary: An open label, phase IIa study conducted in Ethiopia evaluated the efficacy, safety, tolerability, and pharmacokinetics of a single 120-mg dose of the phosphatidylinositol 4-kinase inhibitor MMV390048 in Plasmodium vivax malaria. The study was not completed for operational reasons and emerging teratotoxicity data. MMV390048 exposure in P. vivax patients was lower than previously observed for healthy volunteers. Single-dose MMV390048 (120 mg) rapidly cleared asexual parasites and gametocytes in patients with P. vivax malaria and was well tolerated.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Otorhinolaryngology
Zhenxiao Huang, Bing Zhou, Dehui Wang, Hongrui Zang, Huankang Zhang, Huan Wang, Shenqing Wang, Lei Cheng, Jinrang Li, Wenying Wu, Huifang Zhou, Huili Wu
Summary: This study compared the efficacy of bioabsorbable steroid-eluting sinus stents with absorbable Nasopore packs after endoscopic sinus surgery for chronic rhinosinusitis. Results showed that steroid-eluting stents significantly reduced the need for postoperative surgical intervention and polyp formation compared to Nasopore, and were effective in preventing severe adhesions. Both the stents and Nasopore packs were effective in maintaining ethmoid sinus patency and preventing middle turbinate lateralization. Further prospective cohort studies with long-term outcomes are needed.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Review
Allergy
Yan Feng, Ya-Ping Meng, Ying-Ying Dong, Chang-Yu Qiu, Lei Cheng
Summary: In allergic rhinitis patients, leukotriene receptor antagonists (LTRAs) were found to be more effective in improving nighttime symptoms but less effective in improving daytime nasal symptoms compared to selective H1-antihistamines (SAHs).
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Developmental Biology
Song-Qun Hu, Hui-Min Xu, Fuping Qian, Chang-Sheng Chen, Xin Wang, Dong Liu, Lei Cheng
Summary: The role of IRF7 in hair cell development in zebrafish was investigated, suggesting it may be a member of the deafness gene family. Knockdown of irf7 led to alterations in the expression of multiple genes, ultimately affecting the development of hair cells.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Otorhinolaryngology
Yu Zhang, Qilei Zhang, Xinyang Wu, Geping Wu, Xingkai Ma, Lei Cheng
Summary: This study found that Bicalutamide, an androgen receptor antagonist, has therapeutic effects on an animal model of allergic rhinitis, reducing allergic lesions and suppressing PI3K/PKB activity in mast cells. These results provide important implications for the prevention and treatment of allergic rhinitis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Allergy
Xin-Yuan Chen, Xin-Jie Zhu, Min Chen, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Ruo-Xi Chen, Zhong-Fei Wu, Dong-Yun Bu, Zheng-Dong Zhang, Lei Cheng
Summary: This study found that the SNP rs79525962 in the GARP gene is associated with the risk of persistent allergic rhinitis (PER) sensitized to house dust mites. Different genotypes may result in alterations in the secondary structure of GARP.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Food Science & Technology
Jialu Shi, Youfa Wang, Lei Cheng, Jin Wang, Vijaya Raghavan
Summary: Food allergy has become a global public health issue, especially in developed countries. Recent studies have shown that dysbiosis in the gut microbiota is strongly linked to the increasing prevalence of food allergy. Modulating the gut microbial composition is crucial in regulating the immunogenicity of food antigens. Therefore, probiotics, prebiotics, synbiotics, and postbiotics have attracted significant attention as innovative strategies for preventing and treating food allergy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Yi-Fan Yang, Rui Zheng, Xiang Gu, Fang Gao, Min Chen, Mu-Long Du, Zheng-Dong Zhang, Mei-Ping Lu, Lei Cheng
Summary: This study found that two SNPs in the ferroptosis-related genes ENPP2 and EPAS1 are significantly associated with the risk of house dust mite-induced allergic rhinitis. These genetic variants may serve as potential predictors of susceptibility to house dust mite-induced allergic rhinitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Lin Lin, Lei Cheng
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Xiao-Ying Zhao, Ming Chen, Lei Cheng
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Ying-Ying Zhang, Min Zhang, Jia-Qi Zhang, Qiu-Qi Li, Mei-Ping Lu, Lei Cheng
Summary: Combining AIT with omalizumab can significantly improve the efficacy and safety of AIT in treating allergic diseases, increasing tolerance to allergens and reducing severe systemic adverse events.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Review
Allergy
Chengshuo Wang, Yixiao Bao, Jianjun Chen, Xiaoyang Chen, Lei Cheng, Yin Shi Guo, Chuangli Hao, He Lai, Huabin Li, Jing Li, Changshan Liu, Yun Liu, Zheng Liu, Hongfei Lou, Wei Lv, Guangmin Nong, Qianhui Qiu, Xiumin Ren, Jie Shao, Yi-Hong Shen, Li Shi, Xi-Cheng Song, Yuxin Song, Suping Tang, Hongtian Wang, Xiangdong Wang, Xueyan Wang, Zhenlin Wang, Qingyu Wei, Hua Xie, Zhimin Xing, Rui Xu, Yu Xu, Qintai Yang, Hongmei Yao, Jing Ye, Yiwen You, Hongmeng Yu, Yongmei Yu, Huanping Zhang, Gehua Zhang, Yuan Zhang, Yuxiang Zhi, Weikang Zhou, Li Zhu, Xinhua Zhu, Ruonan Chai, Dehua Chen, Kai Guan, Zizhen Huang, Yanran Huang, Tingting Ma, Yuemei Ma, Yifan Meng, Lei Ren, Jianxing Wang, Nan Wang, Mo Xian, Rong Xiang, Ming Zheng, Luo Zhang
Summary: The prevalence of allergic rhinitis in China has been increasing, with allergen immunotherapy (AIT) being the only curative intervention that aims to improve the immune system and induce immune tolerance. Experts have developed the first English version AIT guidelines for China, leading to progress in basic research and clinical practice, particularly in the use of biomarkers and understanding of AIT during the COVID-19 pandemic.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Allergy
Ruo-Xi Chen, Wen-Min Lu, Mei-Ping Lu, Mei-Lin Wang, Xin-Jie Zhu, Zhong-Fei Wu, Hui-Qin Tian, Lu-Ping Zhu, Zheng-Dong Zhang, Lei Cheng
Summary: In a Han Chinese population, susceptibility to mite-sensitized allergic rhinitis may be associated with two SNPs (rs1590 and rs17023107) in microRNA target sites of TGF-beta signaling pathway genes, when stratified by age and gender.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Allergy
Hao Chen, Jing Li, Lei Cheng, Zhongshan Gao, Xiaoping Lin, Rongfei Zhu, Lin Yang, Ailin Tao, Haiyu Hong, Wei Tang, Yinshi Guo, Huaiqiu Huang, Jinlyu Sun, He Lai, Cheng Lei, Guanghui Liu, Li Xiang, Zhuanggui Chen, Han Ma, Alson Wai-ming Chan, Chuangli Hao, Baoqing Sun
Summary: The prevalence of allergic diseases has been increasing in China in recent years, with allergen identification being key to diagnosis. While various allergy diagnostic methods are available, they are not standardized, making diagnostics more complex due to cross-sensitization and co-sensitization. This consensus aims to standardize allergen diagnostic methods and provide guidance for healthcare professionals, and was prepared by a panel of experts from professional allergy associations in China.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
