Review
Otorhinolaryngology
Dongdong Hong, Juanling Weng, Meiting Ye, Yuanxian Liu
Summary: This study performed a network meta-analysis to evaluate the efficacy of different oral H1 antihistamine treatments for patients with allergic rhinitis. The results suggest that rupatadine is the most effective in alleviating symptoms of patients with allergic rhinitis among the treatments involved.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Review
Pediatrics
Shifang Fu, Yuetong Li, Rongrong Li, Fengjiao Ren, Yinjing Piao, Yanguo Wang, Mingchi Luo
Summary: The study concludes that pediatric tuina, either alone or in combination with other treatments, is clinically effective in treating allergic rhinitis in children, improving symptoms such as nasal congestion, runny nose, sneezing, and turbinate swelling.
FRONTIERS IN PEDIATRICS
(2022)
Review
Medicine, General & Internal
Yong Liao, Juan Zhong, Shuqin Liu, Menglin Dai, Yang Liu, Xinrong Li, Yepeng Yang, Dazheng Zhang, Dan Lai, Tao Lu, Qinxiu Zhang, Yu Zhao
Summary: Through a systematic review of 10 randomized controlled trials, it was found that YPFS did not show significant treatment effects for pediatric allergic rhinitis, but was relatively safe compared to Western medical therapy. Further large-scale studies are needed to conclusively determine the utility of YPFS in the treatment of PAR, despite its good efficacy and safety.
Review
Integrative & Complementary Medicine
Ting Yuan, Jun Xiong, Xue Wang, Jun Yang, Yunfeng Jiang, Xiaohong Zhou, Kai Liao, Lingling Xu
Summary: Indirect moxibustion may have a good clinical effect on the overall treatment of allergic rhinitis and improve the clinical symptoms of patients, but there was no obvious advantage in improving VAS score and Serum IgE level. Due to the limitations of small sample size, moderate quality, and low level of evidence in the included literature, future clinical trials should be designed in strict accordance with the standard of RCT to verify this result.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Review
Medicine, General & Internal
Asti Widuri, Bambang Udji Djoko Rianto, Luh Putu Lusy Indrawati, Ranggaputra Nugraha, Abdul Wahab
Summary: This study aims to systematically review the clinical efficacy of nasal irrigation with various solutions for adults with allergic rhinitis (AR). The study will include randomized controlled trials related to nasal irrigation for AR and provide a summary of the results through data analysis and review.
Article
Allergy
Min-Hye Kim, Kyoung-Hee Sohn, Hye Jung Park, Young Hee Nam, Mi-Hye Kim, Jae-Woo Jung, Jae-Woo Kwon, Yoo Seob Shin, Jong-Sook Park, Young-Joo Cho, Choon-Sik Park, Byoung Whui Choi
Summary: The study evaluated the treatment effects and adverse events of a combination drug called Monterizine (R) (a combination of montelukast and levocetirizine) in patients with perennial allergic rhinitis and asthma. The results showed that TNSS score and quality of life significantly improved after 3-6 months of treatment with Monterizine without significant adverse reactions.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Lukas Israel, Gabriele Rotter, Ulrike Foerster-Ruhrmann, Josef Hummelsberger, Rainer Noegel, Andreas Michalsen, Tatjana Tissen-Diabate, Sylvia Binting, Thomas Reinhold, Miriam Ortiz, Benno Brinkhaus
Summary: Self-administered acupressure as a self-care technique shows potential benefits for patients with seasonal allergic rhinitis, improving disease-specific quality of life and reducing disease-related symptoms and medication intake. High-quality confirmatory studies are needed for further validation of these findings, including a sham-control group.
Review
Allergy
Wasuchon Chaichan, Chidchanok Ruengorn, Kednapa Thavorn, Brian Hutton, Jacek C. Szepietowski, Jonathan A. Bernstein, Mati Chuamanochan, Surapon Nochaiwong
Summary: A systematic review and network meta-analysis were conducted to compare the safety profiles of different second-generation H1-antihistamines in patients with chronic urticaria. The study found variations in safety profiles, with mizolastine, emedastine, and cetirizine associated with unfavorable safety profiles.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Emergency Medicine
Pakhawadee Palungwachira, Ketsara Vilaisri, Khrongwong Musikatavorn, Jongkonnee Wongpiyabovorn
Summary: This study found that adding IV dexamethasone did not improve the treatment of severe pruritus from uncomplicated acute urticaria. Oral corticosteroid therapy may lead to persistent urticaria activity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jian-Feng Zhang, Ying-Dong Wang, Peng Lin, Jun-Chen Li, Chen-Qi Guo, Jing-Bo Zhai, Yu Zhang
Summary: This study systematically evaluated the efficacy and safety of Runzao Zhiyang capsule (RZC) in treating chronic urticaria (CU) and found that RZC combined with second-generation H1-antihistamines (sgAHs) therapy is more effective in improving total effective rate, quality of life, and reducing recurrence rate and adverse events.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Yajie Yan, Jiajun Zhang, Haolan Liu, Ze Lin, Qiulan Luo, Yunying Li, Yan Ruan, Shiqing Zhou
Summary: This study evaluated the effectiveness and safety of Xiao-qing-long-tang (XQLT) in treating allergic rhinitis (AR). The results showed that XQLT can alleviate the symptoms of AR and is safe to use in clinical practice. However, more clinical trials are needed to further evaluate the effectiveness of XQLT.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Otorhinolaryngology
Ying-Ying Zhang, Min Zhang, Jia-Qi Zhang, Qiu-Qi Li, Mei-Ping Lu, Lei Cheng
Summary: Combining AIT with omalizumab can significantly improve the efficacy and safety of AIT in treating allergic diseases, increasing tolerance to allergens and reducing severe systemic adverse events.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Medicine, General & Internal
Ioana Corina Bocsan, Ioana Adriana Muntean, Nicolae Miron, Irena Pintea, Carmen Teodora Dobrican, Corina Ureche, Anca Dana Buzoianu, Diana Deleanu
Summary: Soluble ICAM-1 and VCAM-1 play important roles in allergic rhinitis (AR), and H1 antihistamines can improve AR symptoms and reduce the levels of adhesion molecules. This study found that patients with grass pollen-induced AR had higher levels of ICAM-1 and VCAM-1 compared to healthy controls during pollen exposure. Despite antihistaminic therapy, these levels tended to remain high during pollen season.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Otorhinolaryngology
Nadim Khoueir, Michel G. Khalaf, Ralph Assily, Simon Rassi, Walid Abou Hamad
Summary: This systematic review and meta-analysis examined the effects of intranasal antihistamines (INAH) on idiopathic rhinitis (IR). The study found that INAH had a beneficial effect on improving nasal symptoms compared to placebo. No significant difference in efficacy was observed between different types of INAH. The most commonly reported adverse event was bitter taste sensation.
Review
Otorhinolaryngology
Wirach Chitsuthipakorn, Minh P. Hoang, Dichapong Kanjanawasee, Kachorn Seresirikachorn, Kornkiat Snidvongs
Summary: Combination therapy with antihistamines and intranasal corticosteroids can improve symptoms and quality of life in patients with allergic rhinitis. Adding a decongestant, saline, or leukotriene receptor antagonist to antihistamine monotherapy can improve outcomes. Adding intranasal antihistamines can improve nasal symptoms, leukotriene receptor antagonists can improve ocular symptoms, and saline irrigation can improve quality of life when intranasal corticosteroid monotherapy is ineffective.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Otorhinolaryngology
Zhenxiao Huang, Bing Zhou, Dehui Wang, Hongrui Zang, Huankang Zhang, Huan Wang, Shenqing Wang, Lei Cheng, Jinrang Li, Wenying Wu, Huifang Zhou, Huili Wu
Summary: This study compared the efficacy of bioabsorbable steroid-eluting sinus stents with absorbable Nasopore packs after endoscopic sinus surgery for chronic rhinosinusitis. Results showed that steroid-eluting stents significantly reduced the need for postoperative surgical intervention and polyp formation compared to Nasopore, and were effective in preventing severe adhesions. Both the stents and Nasopore packs were effective in maintaining ethmoid sinus patency and preventing middle turbinate lateralization. Further prospective cohort studies with long-term outcomes are needed.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Allergy
Chang -Yu Qiu, Xin-Yan Cui, Mei-Ping Lu, Min Yin, Wan-Yun Xu, Xin-Jie Zhu, Qing Yang, Lei Cheng
Summary: In this study, significantly differentially expressed circRNAs were identified in allergic rhinitis patients. A circRNA-miRNA-mRNA network was constructed, revealing potential involvement of Wnt signaling pathway, inflammatory responses, etc. in the regulation of allergic rhinitis pathogenesis by circRNAs.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Developmental Biology
Song-Qun Hu, Hui-Min Xu, Fuping Qian, Chang-Sheng Chen, Xin Wang, Dong Liu, Lei Cheng
Summary: The role of IRF7 in hair cell development in zebrafish was investigated, suggesting it may be a member of the deafness gene family. Knockdown of irf7 led to alterations in the expression of multiple genes, ultimately affecting the development of hair cells.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Min Zhang, Jing-Zi Ni, Lei Cheng
Summary: Intranasal corticosteroids (INCSs) have a favorable safety profile and high local-systemic balance of bioavailability with a low incidence of adverse events in the treatment of pediatric allergic rhinitis (AR). However, the use of INCSs should be individualized based on patient response and adverse effects. Evaluation of the benefits and risks of INCSs is necessary to ensure clinical efficacy and prevent potential events.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Otorhinolaryngology
Yu Zhang, Qilei Zhang, Xinyang Wu, Geping Wu, Xingkai Ma, Lei Cheng
Summary: This study found that Bicalutamide, an androgen receptor antagonist, has therapeutic effects on an animal model of allergic rhinitis, reducing allergic lesions and suppressing PI3K/PKB activity in mast cells. These results provide important implications for the prevention and treatment of allergic rhinitis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Allergy
Xin-Yuan Chen, Xin-Jie Zhu, Min Chen, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Ruo-Xi Chen, Zhong-Fei Wu, Dong-Yun Bu, Zheng-Dong Zhang, Lei Cheng
Summary: This study found that the SNP rs79525962 in the GARP gene is associated with the risk of persistent allergic rhinitis (PER) sensitized to house dust mites. Different genotypes may result in alterations in the secondary structure of GARP.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Food Science & Technology
Jialu Shi, Youfa Wang, Lei Cheng, Jin Wang, Vijaya Raghavan
Summary: Food allergy has become a global public health issue, especially in developed countries. Recent studies have shown that dysbiosis in the gut microbiota is strongly linked to the increasing prevalence of food allergy. Modulating the gut microbial composition is crucial in regulating the immunogenicity of food antigens. Therefore, probiotics, prebiotics, synbiotics, and postbiotics have attracted significant attention as innovative strategies for preventing and treating food allergy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Yi-Fan Yang, Rui Zheng, Xiang Gu, Fang Gao, Min Chen, Mu-Long Du, Zheng-Dong Zhang, Mei-Ping Lu, Lei Cheng
Summary: This study found that two SNPs in the ferroptosis-related genes ENPP2 and EPAS1 are significantly associated with the risk of house dust mite-induced allergic rhinitis. These genetic variants may serve as potential predictors of susceptibility to house dust mite-induced allergic rhinitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Lin Lin, Lei Cheng
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Xiao-Ying Zhao, Ming Chen, Lei Cheng
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Ying-Ying Zhang, Min Zhang, Jia-Qi Zhang, Qiu-Qi Li, Mei-Ping Lu, Lei Cheng
Summary: Combining AIT with omalizumab can significantly improve the efficacy and safety of AIT in treating allergic diseases, increasing tolerance to allergens and reducing severe systemic adverse events.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Review
Allergy
Chengshuo Wang, Yixiao Bao, Jianjun Chen, Xiaoyang Chen, Lei Cheng, Yin Shi Guo, Chuangli Hao, He Lai, Huabin Li, Jing Li, Changshan Liu, Yun Liu, Zheng Liu, Hongfei Lou, Wei Lv, Guangmin Nong, Qianhui Qiu, Xiumin Ren, Jie Shao, Yi-Hong Shen, Li Shi, Xi-Cheng Song, Yuxin Song, Suping Tang, Hongtian Wang, Xiangdong Wang, Xueyan Wang, Zhenlin Wang, Qingyu Wei, Hua Xie, Zhimin Xing, Rui Xu, Yu Xu, Qintai Yang, Hongmei Yao, Jing Ye, Yiwen You, Hongmeng Yu, Yongmei Yu, Huanping Zhang, Gehua Zhang, Yuan Zhang, Yuxiang Zhi, Weikang Zhou, Li Zhu, Xinhua Zhu, Ruonan Chai, Dehua Chen, Kai Guan, Zizhen Huang, Yanran Huang, Tingting Ma, Yuemei Ma, Yifan Meng, Lei Ren, Jianxing Wang, Nan Wang, Mo Xian, Rong Xiang, Ming Zheng, Luo Zhang
Summary: The prevalence of allergic rhinitis in China has been increasing, with allergen immunotherapy (AIT) being the only curative intervention that aims to improve the immune system and induce immune tolerance. Experts have developed the first English version AIT guidelines for China, leading to progress in basic research and clinical practice, particularly in the use of biomarkers and understanding of AIT during the COVID-19 pandemic.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Allergy
Ruo-Xi Chen, Wen-Min Lu, Mei-Ping Lu, Mei-Lin Wang, Xin-Jie Zhu, Zhong-Fei Wu, Hui-Qin Tian, Lu-Ping Zhu, Zheng-Dong Zhang, Lei Cheng
Summary: In a Han Chinese population, susceptibility to mite-sensitized allergic rhinitis may be associated with two SNPs (rs1590 and rs17023107) in microRNA target sites of TGF-beta signaling pathway genes, when stratified by age and gender.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)