Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action

Per- and polyfluoroalkyl substances in serum and associations with food consumption and use of personal care products in the Norwegian biomonitoring study from the EU project EuroMix

(2021) E. Thépaut et al.   ENVIRONMENTAL RESEARCH

An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects

(2021) Elena Menegola et al.   TOXICOLOGY

A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat

(2021) Justin M. Conley et al.   ENVIRONMENT INTERNATIONAL

Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos

(2020) Maria Zoupa et al.   FOOD AND CHEMICAL TOXICOLOGY

The MCRA toolbox of models and data to support chemical mixture risk assessment

(2020) Hilko van der Voet et al.   FOOD AND CHEMICAL TOXICOLOGY

Defining embryonic developmental effects of chemical mixtures using the embryonic stem cell test

(2020) Conny TM. van Oostrom et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

(2020) T. Husøy et al.   FOOD AND CHEMICAL TOXICOLOGY

Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures

(2020) Harm J. Heusinkveld et al.   REPRODUCTIVE TOXICOLOGY

Ten years of research on synergisms and antagonisms in chemical mixtures: A systematic review and quantitative reappraisal of mixture studies

(2020) Olwenn Martin et al.   ENVIRONMENT INTERNATIONAL

Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution

(2019) S. Rotter et al.   CRITICAL REVIEWS IN TOXICOLOGY

Modelling aggregate exposure to pesticides from dietary and crop spray sources in UK residents

(2019) Marc C. Kennedy et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The Norwegian biomonitoring study from the EU project EuroMix: Levels of phenols and phthalates in 24-hour urine samples and exposure sources from food and personal care products

(2019) T. Husøy et al.   ENVIRONMENT INTERNATIONAL

The EuroMix human biomonitoring study: Source-to-dose modeling of cumulative and aggregate exposure for the bisphenols BPA, BPS, and BPF and comparison with measured urinary levels

(2019) Cecile Karrer et al.   ENVIRONMENT INTERNATIONAL

Concentration addition and independent action model: Which is better in predicting the toxicity for metal mixtures on zebrafish larvae

(2018) Yongfei Gao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds

(2018) Yvonne C. M. Staal et al.   ARCHIVES OF TOXICOLOGY

Selecting mixtures on the basis of dietary exposure and hazard data: application to pesticide exposure in the European population in relation to steatosis

(2018) Amélie Crépet et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Zebrafish Models of Human Disease: Gaining Insight into Human Disease at ZFIN

(2017) Yvonne M. Bradford et al.   ILAR JOURNAL

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation

(2017) Kathrin Wiebke Schulte et al.   STRUCTURE

Identification of shared and unique gene families associated with oral clefts

(2017) Noriko Funato et al.   International Journal of Oral Science

Regulatory assessment of chemical mixtures: Requirements, current approaches and future perspectives

(2016) Aude Kienzler et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish

(2016) Joshua T. Gamse et al.   Zebrafish

Retinoic acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo

(2015) Tadahiro Shimomura et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Benchmark dose and the three Rs. Part I. Getting more information from the same number of animals

(2014) Wout Slob   CRITICAL REVIEWS IN TOXICOLOGY

Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment

(2014) Andreas Kortenkamp   CURRENT OPINION IN PHARMACOLOGY

Quantifying Synergy: A Systematic Review of Mixture Toxicity Studies within Environmental Toxicology

(2014) Nina Cedergreen   PLoS One

Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants

(2013) Shengde Wu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Shape and steepness of toxicological dose–response relationships of continuous endpoints

(2013) Wout Slob et al.   CRITICAL REVIEWS IN TOXICOLOGY

Evaluation of an alternative in vitro test battery for detecting reproductive toxicants

(2013) A.H. Piersma et al.   REPRODUCTIVE TOXICOLOGY

Triazole-induced gene expression changes in the zebrafish embryo

(2012) Sanne A.B. Hermsen et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish for drug toxicity screening: bridging thein vitrocell-based models andin vivomammalian models

(2011) Hendrian Sukardi et al.   Expert Opinion on Drug Metabolism & Toxicology

Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies

(2011) Sanne A.B. Hermsen et al.   TOXICOLOGY IN VITRO

CAESAR models for developmental toxicity

(2010) Antonio Cassano et al.   Chemistry Central Journal

Retinoic acid affects craniofacial patterning by changing Fgf8 expression in the pharyngeal ectoderm

(2010) Makoto Abe et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Dithiocarbamates Induce Craniofacial Abnormalities and Downregulate sox9a during Zebrafish Development

(2010) Antonius Leonardus van Boxtel et al.   TOXICOLOGICAL SCIENCES

Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity

(2010) Antonius L. van Boxtel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SCORE Imaging: Specimen in a Corrected Optical Rotational Enclosure

(2010) Andrew M. Petzold et al.   Zebrafish

Dose addition and the isobole method as approaches for predicting the cumulative effect of non-interacting chemicals: A critical evaluation

(2009) Sieto Bosgra et al.   CRITICAL REVIEWS IN TOXICOLOGY

An integrated probabilistic framework for cumulative risk assessment of common mechanism chemicals in food: An example with organophosphorus pesticides

(2009) Sieto Bosgra et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols