The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

The growing landscape of succinylation links metabolism and heart disease

(2021) Lanting Yang et al.   Epigenomics

Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets

(2020) Marike W. van Gisbergen et al.   Frontiers in Oncology

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

(2020) Tongxin Ge et al.   Frontiers in Endocrinology

Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

(2020) Chunhua Jiang et al.   Frontiers in Cell and Developmental Biology

N-degron and C-degron pathways of protein degradation

(2019) Alexander Varshavsky   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Topological Parameters of Complex Disease Genes Reveals the Importance of Location in a Biomolecular Network

(2019) Xiaohui Zhao et al.   Genes

Loss of the HIF pathway in a widely distributed intertidal crustacean, the copepodTigriopus californicus

(2019) Allie M. Graham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

(2019) Norma Masson et al.   SCIENCE

The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments

(2018) Daniel B Mills et al.   eLife

Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis

(2018) Michael D. Birnbaum et al.   ONCOGENE

Target site specificity and in vivo complexity of the mammalian arginylome

(2018) Junling Wang et al.   Scientific Reports

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

(2017) Mark D. White et al.   Nature Communications

Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth

(2017) Masaru Koido et al.   Oncotarget

Analysis of the relationship between coexpression domains and chromatin 3D organization

(2017) María E. Soler-Oliva et al.   PLoS Computational Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response

(2016) Akhilesh Kumar et al.   Cell Death & Disease

Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers

(2015) R Rai et al.   ONCOGENE

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

(2015) Fangliang Zhang et al.   Nature Communications

Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats

(2014) Christopher S. Brower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway

(2013) Christopher S. Brower et al.   MOLECULAR CELL

An archaeal origin of eukaryotes supports only two primary domains of life

(2013) Tom A. Williams et al.   NATURE

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

A Heme-Sensing Mechanism in the Translational Regulation of Mitochondrial Cytochrome c Oxidase Biogenesis

(2012) Iliana C. Soto et al.   Cell Metabolism

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell–cell adhesion

(2012) Fangliang Zhang et al.   JOURNAL OF CELL BIOLOGY

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

(2012) K. I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Evolution

(2012) M. W. Gray   Cold Spring Harbor Perspectives in Biology

Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation

(2012) Jing-Yu Li et al.   PLoS Genetics

Arginyltransferase Is an ATP-Independent Self-Regulating Enzyme that Forms Distinct Functional Complexes In Vivo

(2011) Junling Wang et al.   CHEMISTRY & BIOLOGY

UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition

(2011) Rasheda Sultana et al.   EXPERIMENTAL CELL RESEARCH

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

(2011) Francesco Licausi et al.   NATURE

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

(2011) Daniel J. Gibbs et al.   NATURE

T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension

(2011) P. Di Tommaso et al.   NUCLEIC ACIDS RESEARCH

Plant Oxygen Sensing Is Mediated by the N-End Rule Pathway: A Milestone in Plant Anaerobiosis

(2011) R. Sasidharan et al.   PLANT CELL

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

The arginylation-dependent association of calreticulin with stress granules is regulated by calcium

(2010) Marcos A. Carpio et al.   BIOCHEMICAL JOURNAL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence-Dependent Degradation

(2010) F. Zhang et al.   SCIENCE

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway

(2008) Zanxian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY