期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 74, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2022.102388
关键词
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资金
- National Natural Science Foundation of China [32022037, 31971123]
- Leading Innovative and Entrepreneur Team Introduction Program of Hangzhou
- Special Research Program of Novel Coronavirus Pneumonia of Westlake University
- Tencent Foundation
- Westlake Education Foundation
This article provides an overview of the functional and structural studies on ACE2 receptor and the spike protein of coronaviruses, and discusses the relationship between the symptoms of COVID-19 and ACE2.
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a public health crisis and led to tremendous economic devastation. The spike protein (S) of SARS-CoV-2 hijacks the angiotensin converting enzyme 2 (ACE2) as a receptor for virus entry, representing the initial step of viral infection. S is one of the major targets for development of the antiviral drugs, antibodies, and vaccines. ACE2 is a peptidase that plays a physiologically important role in the renin-angiotensin system. Concurrently, it also forms dimer of heterodimer with the neutral amino acid transporter B(0)AT1 to regulate intestinal amino acid metabolism. The symptoms of COVID-19 are closely correlated with the physiological functions of ACE2. In this review, we summarize the functional and structural studies on ACE2, B(0)AT1, and their complex with S of SARS-CoV-2, providing insights into the various symptoms caused by viral infection and the development of therapeutic strategies.
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