Revealing the secret behind Smo cholesterylation

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

(2022) Ao Hu et al.   CELL RESEARCH

Hedgehog signaling mechanism and role in cancer

(2021) Jin Jiang   SEMINARS IN CANCER BIOLOGY

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

(2020) Xiaofeng Qi et al.   Nature Chemical Biology

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

(2019) Xiaofeng Qi et al.   NATURE

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

(2019) Ishan Deshpande et al.   NATURE

Structural Basis of Smoothened Activation in Hedgehog Signaling

(2018) Pengxiang Huang et al.   CELL

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

(2017) Xu Xiao et al.   MOLECULAR CELL

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE