What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?

Requirement for antiapoptotic MCL-1 during early erythropoiesis

(2021) Meghan E. Turnis et al.   BLOOD

The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis

(2021) Robert T. Flemmer et al.   Frontiers in Cell and Developmental Biology

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

(2021) Lahiru Gangoda et al.   CELL DEATH AND DIFFERENTIATION

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

(2020) Mathias Uhlen et al.   SCIENCE

An atlas of the protein-coding genes in the human, pig, and mouse brain

(2020) Evelina Sjöstedt et al.   SCIENCE

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

(2020) Xuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

(2020) Marc E. Healy et al.   GASTROENTEROLOGY

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

(2020) Xuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage

(2020) Kerstin Brinkmann et al.   EMBO JOURNAL

Venetoclax penetrates in cerebrospinal fluid and may be effective in CLL with central nervous system involvement.

(2019) Gianluigi Reda et al.   HAEMATOLOGICA

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

A Phase 1, First-in-Human Study of AMG 176, a Selective MCL-1 Inhibitor, in Patients With Relapsed or Refractory Multiple Myeloma

(2019) Andrew Spencer et al.   Clinical Lymphoma Myeloma & Leukemia

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

(2018) Matthew S. Davids et al.   CLINICAL CANCER RESEARCH

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition

(2018) Clare E. Weeden et al.   ONCOGENE

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

(2018) Monika A Jakubowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Revised Dose Ramp-Up to Mitigate the Risk of Tumor Lysis Syndrome When Initiating Venetoclax in Patients With Mantle Cell Lymphoma

(2018) Matthew S. Davids et al.   JOURNAL OF CLINICAL ONCOLOGY

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

(2018) Jarny Choi et al.   NUCLEIC ACIDS RESEARCH

BCL-W has a fundamental role in B cell survival and lymphomagenesis

(2017) Clare M. Adams et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

(2017) Charlotte Viant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1

(2016) E C Watson et al.   CELL DEATH AND DIFFERENTIATION

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

(2016) Carolyn A. de Graaf et al.   Stem Cell Reports

Bcl-2 is required for the survival of doublecortin-expressing immature neurons

(2015) Maheen Ceizar et al.   HIPPOCAMPUS

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

(2015) Nai Yang Fu et al.   NATURE CELL BIOLOGY

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

(2015) Emma M. Carrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

BCL-2 is dispensable for thrombopoiesis and platelet survival

(2015) M A Debrincat et al.   Cell Death & Disease

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity

(2014) R. W. Rooswinkel et al.   BLOOD

Developmental Regulated Expression of Anti- and Pro-Apoptotic BCL-2 Family Genes During Human Early Embryonic Development

(2014) I. Boumela et al.   CURRENT MEDICINAL CHEMISTRY

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

(2014) G. L. Kelly et al.   GENES & DEVELOPMENT

Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer

(2014) W Nakajima et al.   Cell Death & Disease

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL

(2014) Michael F. T. Koehler et al.   ACS Medicinal Chemistry Letters

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

(2014) Zhi-Fu Tao et al.   ACS Medicinal Chemistry Letters

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

(2014) Priyanka Sathe et al.   Nature Communications

The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells

(2013) Renata P. Guedes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

(2013) R. L. Thomas et al.   GENES & DEVELOPMENT

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

(2013) X. Wang et al.   GENES & DEVELOPMENT

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-XL

(2013) Brad E. Sleebs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

(2012) M. A. Debrincat et al.   BLOOD

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

(2012) D. Merino et al.   BLOOD

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

(2012) T Kodama et al.   CELL DEATH AND DIFFERENTIATION

Transfer of CD8+ T Cell Memory Using Bcl-2 as a Marker

(2012) A. Dunkle et al.   JOURNAL OF IMMUNOLOGY

Mcl-1 regulates the survival of adult neural precursor cells

(2012) Craig D. Malone et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Delving deeper: MCL-1's contributions to normal and cancer biology

(2012) Rhonda M. Perciavalle et al.   TRENDS IN CELL BIOLOGY

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl-2 Allows Effector and Memory CD8+ T Cells To Tolerate Higher Expression of Bim

(2011) S. Kurtulus et al.   JOURNAL OF IMMUNOLOGY

Survivin Inhibition Is Critical for Bcl-2 Inhibitor-Induced Apoptosis in Hepatocellular Carcinoma Cells

(2011) Xiangxuan Zhao et al.   PLoS One

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

(2010) Scott Ackler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer

(2010) Shih-Yen Weng et al.   JOURNAL OF HEPATOLOGY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

(2010) I. Vikstrom et al.   SCIENCE

Epithelial Ablation of Bcl-XLIncreases Sensitivity to Oxygen without Disrupting Lung Development

(2009) Rhonda J. Staversky et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Islet  -Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

(2009) E. M. Carrington et al.   DIABETES

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

(2009) Hayato Hikita et al.   HEPATOLOGY

Baxβ: A Constitutively Active Human Bax Isoform that Is under Tight Regulatory Control by the Proteasomal Degradation Mechanism

(2009) Nai Yang Fu et al.   MOLECULAR CELL

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

(2008) D. A. Steimer et al.   BLOOD

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models

(2008) A. R. Shoemaker et al.   CLINICAL CANCER RESEARCH

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage

(2008) N. Arbour et al.   JOURNAL OF NEUROSCIENCE