Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits

(2021) Lei Zhang et al.   CELL BIOLOGY AND TOXICOLOGY

Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism

(2019) Yannick Degboé et al.   Frontiers in Immunology

Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway

(2019) Rui Liu et al.   JOURNAL OF IMMUNOLOGY

Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation

(2019) Qian Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Erythropoietin Reduces Neurodegeneration and Long-Term Memory Deficits Following Sevoflurane Exposure in Neonatal Rats

(2019) Toru Goyagi   NEUROTOXICITY RESEARCH

The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats

(2019) Fan Yang et al.   Frontiers in Neuroscience

Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN

(2019) Lei Zhang et al.   EBioMedicine

Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

(2019) Xin Jin et al.   PHARMACOLOGICAL RESEARCH

Serum Ngb (Neuroglobin) Is Associated With Brain Metabolism and Functional Outcome of Aneurysmal Subarachnoid Hemorrhage

(2019) Chen-Yu Ding et al.   STROKE

IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole

(2019) Ágata C. Cevey et al.   Frontiers in Immunology

Neuroglobin protects offspring rats from neuronal damage induced by sevoflurane exposure to pregnant rats by inhibiting endogenous apoptosis

(2019) Yongfang Zhang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling

(2019) Yan Gao et al.   LIFE SCIENCES

Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by General Anesthesia in Neonatal Mice

(2019) Hengchang Li et al.   Frontiers in Neuroscience

Cistanches alleviates sevoflurane‐induced cognitive dysfunction by regulating PPAR‐γ‐dependent antioxidant and anti‐inflammatory in rats

(2019) Sheng Peng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway

(2018) Juan Ji et al.   AGING CELL

Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus

(2018) Ping Dong et al.   BEHAVIOURAL BRAIN RESEARCH

Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells

(2018) Lili Xu et al.   BRAIN RESEARCH BULLETIN

Hypoxia-Induced Neuroinflammation and Learning–Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine

(2018) Yunkyoung Lee et al.   MOLECULAR NEUROBIOLOGY

Recombinant neuroglobin ameliorates early brain injury after subarachnoid hemorrhage via inhibiting the activation of mitochondria apoptotic pathway

(2018) Fuxiang Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise

(2018) Ziyi Wu et al.   Frontiers in Cellular Neuroscience

Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases

(2018) Haixia Wen et al.   Cell Death & Disease

TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway

(2018) Ran Li et al.   Journal of Neuroinflammation

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

(2018) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury

(2018) Eliana Baez-Jurado et al.   MOLECULAR NEUROBIOLOGY

Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1–Bax signaling

(2018) Yangyang Shan et al.   Drug Design Development and Therapy

Dexmedetomidine Ameliorates the Neurotoxicity of Sevoflurane on the Immature Brain Through the BMP/SMAD Signaling Pathway

(2018) Yangyang Shan et al.   Frontiers in Neuroscience

MicroRNA-27a-3p suppression of peroxisome proliferator-activated receptor-γ contributes to cognitive impairments resulting from sevoflurane treatment

(2017) Xiang Lv et al.   JOURNAL OF NEUROCHEMISTRY

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

(2017) James P. Barrett et al.   Journal of Neuroinflammation

Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta

(2017) Oscar Hidalgo-Lanussa et al.   MOLECULAR NEUROBIOLOGY

Hemin protects against oxygen–glucose deprivation-induced apoptosis activation via neuroglobin in SH-SY5Y cells

(2017) Yun-Jia Wang et al.   NEUROCHEMICAL RESEARCH

Sevoflurane suppresses microglial M2 polarization

(2017) Zengyang Pei et al.   NEUROSCIENCE LETTERS

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats

(2017) Xingyue Li et al.   Frontiers in Molecular Neuroscience

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibiting NADPH oxidase protects against long-term memory impairment induced by neonatal sevoflurane exposure in mice

(2016) Z. Sun et al.   BRITISH JOURNAL OF ANAESTHESIA

Neuroglobin protects astroglial cells from hydrogen peroxide-induced oxidative stress and apoptotic cell death

(2016) Fatma Amri et al.   JOURNAL OF NEUROCHEMISTRY

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model

(2016) Noemie Tentillier et al.   JOURNAL OF NEUROSCIENCE

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

(2016) Zhenxing Liang et al.   PROGRESS IN NEUROBIOLOGY

Expression and Cell Distribution of Neuroglobin in the Brain Tissue After Experimental Subarachnoid Hemorrhage in Rats: A Pilot Study

(2013) Wei-De Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hemin-mediated neuroglobin induction exerts neuroprotection following ischemic brain injury through PI3K/Akt signaling

(2013) BEI ZHANG et al.   Molecular Medicine Reports

Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders

(2012) Zhanyang Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

17β-Oestradiol Anti-Inflammatory Effects in Primary Astrocytes Require Oestrogen Receptor β-Mediated Neuroglobin Up-Regulation

(2012) E. De Marinis et al.   JOURNAL OF NEUROENDOCRINOLOGY

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

Systemic infection and delirium: when cytokines and acetylcholine collide

(2010) Willem A van Gool et al.   LANCET