Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice

The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders

(2021) Sofia Dionysopoulou et al.   Nutrients

Western Diet Consumption During Development: Setting the Stage for Neurocognitive Dysfunction

(2021) Linda Tsan et al.   Frontiers in Neuroscience

PEA prevented early BBB disruption after cerebral ischaemic/reperfusion (I/R) injury through regulation of ROCK/MLC signaling

(2021) Dequan Kong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAAA inhibitor F96 attenuates BBB disruption and secondary injury after traumatic brain injury (TBI)

(2021) Yitian Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stress and Psychiatric Disorders: The Role of Mitochondria

(2020) Teresa E. Daniels et al.   Annual Review of Clinical Psychology

Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer’s Disease

(2020) Sarah Beggiato et al.   Journal of Clinical Medicine

Palmitoylethanolamide counteracts brain fog improving depressive‐like behaviour in obese mice: possible role of synaptic plasticity and neurogenesis

(2020) Adriano Lama et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ciliary Neurotrophic Factor Acts on Distinctive Hypothalamic Arcuate Neurons and Promotes Leptin Entry Into and Action on the Mouse Hypothalamus

(2020) Wiebe Venema et al.   Frontiers in Cellular Neuroscience

Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis

(2020) Gustavo E. Tafet et al.   Frontiers in Psychiatry

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

(2019) Blanca Lizarbe et al.   Frontiers in Neuroscience

Activation of PPAR-α by N-palmitoylethanolamine engages allopregnanolone biosynthesis to modulate emotional behavior

(2019) Andrea Locci et al.   BIOLOGICAL PSYCHIATRY

“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

(2019) Dongsheng Cai et al.   Cell Metabolism

High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats

(2019) Min Yu et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

(2019) Gunnar R. Leitner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Butyrate prevents valproate‐induced liver injury: In vitro and in vivo evidence

(2019) Claudio Pirozzi et al.   FASEB JOURNAL

Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet‐induced obese mice

(2019) Chiara Annunziata et al.   FASEB JOURNAL

High-Fat Diet Induces Neuroinflammation and Mitochondrial Impairment in Mice Cerebral Cortex and Synaptic Fraction

(2019) Gina Cavaliere et al.   Frontiers in Cellular Neuroscience

Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice

(2019) A. Pierre et al.   PSYCHONEUROENDOCRINOLOGY

Depression and obesity: evidence of shared biological mechanisms

(2018) Yuri Milaneschi et al.   MOLECULAR PSYCHIATRY

Macrophage polarization and meta-inflammation

(2018) Chuan Li et al.   Translational Research

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

(2018) Stefania Petrosino et al.   Frontiers in Pharmacology

Palmitoylethanolamide counteracts autistic-like behaviours in BTBR T+tf/J mice: Contribution of central and peripheral mechanisms

(2018) Claudia Cristiano et al.   BRAIN BEHAVIOR AND IMMUNITY

Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis

(2018) Aitak Farzi et al.   MOLECULAR ASPECTS OF MEDICINE

EGCG ameliorates high-fat– and high-fructose–induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

(2017) Yashi Mi et al.   FASEB JOURNAL

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

(2017) Qingzhi Wang et al.   MOLECULAR NEUROBIOLOGY

Mast cells in neuroinflammation and brain disorders

(2017) Erik Hendriksen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The impact of obesity and hypercaloric diet consumption on anxiety and emotional behavior across the lifespan

(2017) Kathryn D. Baker et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

(2017) Stephen D. Skaper et al.   NEUROSCIENTIST

Obesity-Induced Neuroinflammation: Beyond the Hypothalamus

(2017) Owein Guillemot-Legris et al.   TRENDS IN NEUROSCIENCES

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

(2017) J.D. Douglass et al.   Molecular Metabolism

Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines

(2017) Ophélia Le Thuc et al.   Frontiers in Endocrinology

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

(2016) Stefania Petrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice

(2015) T. M. Zaved Waise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

(2015) Norman R. Saunders et al.   Frontiers in Neuroscience

Obesity and neuroinflammation: A pathway to cognitive impairment

(2014) Alyson A. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Palmitoylethanolamide Prevents Metabolic Alterations and Restores Leptin Sensitivity in Ovariectomized Rats

(2014) G. Mattace Raso et al.   ENDOCRINOLOGY

Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study

(2014) Kathryn E. Berkseth et al.   ENDOCRINOLOGY

Palmitoylethanolamide in CNS health and disease

(2014) Giuseppina Mattace Raso et al.   PHARMACOLOGICAL RESEARCH

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Effects of Palmitoylethanolamide and Luteolin in an Animal Model of Anxiety/Depression

(2013) Rosalia Crupi et al.   CNS & Neurological Disorders-Drug Targets

Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling

(2012) Oliver Braganza et al.   EPILEPSIA

Regional astrogliosis in the mouse hypothalamus in response to obesity

(2012) Laura B. Buckman et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

(2011) G. Mattace Raso et al.   JOURNAL OF NEUROENDOCRINOLOGY

Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines

(2011) Anna Pietrzak et al.   MEDIATORS OF INFLAMMATION

Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain

(2011) Oscar Sasso et al.   PAIN

Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice

(2009) Oscar Sasso et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Stress, memory and the amygdala

(2009) Benno Roozendaal et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE