Article
Neurosciences
Jaehyun Kim, Tae Hyon Ha, Kiwon Kim, Eun-Mi Lee, Hyekyeong Kim, Doh Kwan Kim, Hong-Hee Won, Matthew Lewis, Hyewon Lee, Woojae Myung
Summary: The study found that the use of atypical antipsychotic drugs in elderly individuals with depressive disorders is associated with a significantly higher risk of subsequent dementia. Risperidone showed the highest risk for dementia among atypical antipsychotics. Healthcare professionals should be aware of this potential long-term risk when prescribing these medications.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Endocrinology & Metabolism
Zhaoxia Wu, Pengjiao Xi, Yan Zhang, Haomin Wang, Jie Xue, Xuguo Sun, Derun Tian
Summary: Diet-induced obesity is associated with chronic inflammation in the hypothalamus. Overexpression of LKB1 in hypothalamus can attenuate inflammation, reduce food intake and weight gain, improve lipid metabolism, and decrease hepatic fat accumulation. This suggests LKB1 as a potential target for treating obesity and other inflammatory diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Medicine, General & Internal
Kathryn Meldrum, Ellaina Andersson, Betty Sagigi, Torres Webb, Chenoa Wapau, Rachel Quigley, Edward Strivens, Sarah Russell
Summary: This study aims to develop a mental well-being screening tool for older adults in the Torres Strait that can be used in primary health and geriatric settings. Yarning circles will be conducted to gather information about social and emotional well-being among First Nations peoples in the region. The data will be analyzed thematically and led by Torres Strait Islander members of the research team. The study has been approved by ethics committees and the findings will be disseminated through conferences and peer-reviewed publications.
Article
Clinical Neurology
Fernanda de Oliveira Meller, Luana Meller Manosso, Antonio Augusto Schafer
Summary: This study found a direct association between diet quality and depression symptoms among Brazilians, with individuals consuming soda or artificial juice and unhealthy diets being more likely to have major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Dara K. Y. Leung, Kayla K. Y. Wong, Aimee Spector, Gloria H. Y. Wong
Summary: The study found that Chinese carers adopt strategies such as maintaining the personhood of the person with dementia, responding positively to BPSD, explanation and bargaining, responding negatively to BPSD, controlling upsetting thoughts, and seeking respite care to manage BPSD. They value warm and supportive family relationships, identify and minimize triggers, but some may struggle with care tasks. Changing attitudes, seeking social and emotional support, and practicing self-care were described to manage carers' distress.
Article
Cell Biology
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Galecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim
Summary: This study examines the association between the reoccurrence of illness (ROI), the phenome of depression, and major dysmood disorder (MDMD) features and immune response in major depressive disorder and a major depressive episode (MDD/MDE). The results show that MDMD is characterized by heightened immune responses, which are a consequence of ROI-associated sensitization combined with immunostimulatory triggers.
Article
Geriatrics & Gerontology
Luisa Lampignano, Rodolfo Sardone, Francesca D'Urso, Mario Altamura, Carla Piccininni, Chiara Griseta, Ilaria Bortone, Fabio Castellana, Roberta Zupo, Rossella Donghia, Vito Guerra, Emanuela Resta, Annamaria Cisternino, Maria Gabriella Caruso, Antonio Daniele, Giovanni De Pergola, Antonello Bellomo, Heiner Boeing, Gianluigi Giannelli, Francesco Panza, Madia Lozupone
Summary: This study investigated the relationship between dietary habits and the incidence of late-onset depression. The results showed that consuming processed meat was associated with an increased risk of LOD.
Review
Biochemistry & Molecular Biology
Ashley Selman, Scott Burns, Arubala P. Reddy, John Culberson, P. Hemachandra Reddy
Summary: Chronic conditions such as obesity, diabetes, and dementia are increasing in the US population. They share similar origins and risk factors, including age, genetic predisposition, depression, and a high-fat diet. Obesity is a key factor leading to diabetes, while dementia can be prevented through lifestyle changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Murilo Bastos, Michael Pereira da Silva, Danyele da Silva, Glauco Nonose Negrao, Graziele Schumanski, Weber Claudio Francisco Nunes da Silva, Juliana Sartori Bonini, Leonardo Costa Pereira
Summary: This study aimed to assess the prevalence and mortality rates of Alzheimer's disease among Brazilian elderly and investigate their associations with sociodemographic and lifestyle factors. It also analyzed the prevalence and mortality rates in Brazilian state capitals. The findings showed positive and negative correlations between Alzheimer's disease rates and various factors, such as healthcare coverage, food consumption, and physical activity levels.
Article
Biochemistry & Molecular Biology
Pengjiao Xi, Wenjuan Zhu, Yan Zhang, Meng Wang, Huimin Liang, Haomin Wang, Derun Tian
Summary: The study reveals the significant role of hypothalamic TRPV4 in obesity. Overexpressed hypothalamic TRPV4 leads to weight gain, fat accumulation, and hepatic steatosis, while reducing central inflammation induced by high-fat diet. This suggests that hypothalamic TRPV4 could serve as a potential target for therapeutic intervention against obesity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Medicine, General & Internal
Dimitrios Saredakis, Hannah A. D. Keage, Megan Corlis, Tobias Loetscher
Summary: This study aims to identify changes in apathy after a reminiscence therapy intervention using head-mounted displays (HMDs). Participants will be allocated to three groups for comparison: VR reminiscence therapy group, an active control group using laptop computer or physical items, and a passive control group. Results will be disseminated through academic publications and international conferences.
Article
Medicine, General & Internal
Kimberley S. van Schooten, Michele L. Callisaya, Bridianne O'Dea, Thomas Lung, Kaarin Anstey, Stephen R. Lord, Helen Christensen, Alicia Brown, Jessica Chow, Garth McInerney, Lillian Miles, Michelle Ngo, Amy Perram, Kim Delbaere
Summary: This study aims to evaluate the effectiveness of an eHealth program targeting the cumulative effects of key fall-risk factors in older people. Through a randomized controlled trial, 518 older adults with high fall risk will be recruited to assess outcomes including fall rate, program adherence, healthcare utilization, quality of life, among others.
Article
Chemistry, Medicinal
Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Atapol Sughondhabirom, Kitiporn Plaimas, Apichat Suratanee, Michael Maes
Summary: This study examines the effects of cannabidiol (CBD) on the immune-inflammatory response and immune-regulatory system in patients with depression and healthy controls. The results suggest that higher concentrations of CBD may worsen inflammatory processes.
Article
Medicine, General & Internal
Wenting Peng, Christina E. Miyawaki, Safiyyah M. Okoye, Wenru Wang, Yuqian Luo, Cen Mo, Minhui Liu
Summary: This study investigates the relationship between depressive symptoms and cognitive impairment in older adults and finds that homebound status mediates this association. Interventions to promote outdoor mobility can delay cognitive impairment in older adults with depressive symptoms.
Review
Pharmacology & Pharmacy
Dongliang Liu, Yue Hu, Dali Wang, Hezhou Han, Yi Wang, Xilu Wang, Zhaoyu Zhou, Xiulan Ma, Yaodong Dong
Summary: Tinnitus, the perception of sound in the absence of external stimuli, is prevalent in adults and particularly the elderly. It can lead to cognitive decline and significantly impact quality of life. While various interventions have been used, there are no approved drugs for tinnitus treatment, although herbal medicines such as Ginkgo biloba are commonly used. This literature review evaluates the efficacy of herbal medicines in the treatment of tinnitus and highlights the issues in existing clinical trials, which have inconsistent conclusions due to insufficient evidence.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nicolas C. Nicolaides, Evangelia Charmandari
Summary: Glucocorticoids play a crucial role in restoring homeostasis in response to stress. Inappropriate glucocorticoid signaling can lead to pathological conditions, emphasizing the importance of understanding these rare endocrinologic diseases and improving therapeutic management through advancements in structural, molecular, and cellular biology, as well as biotechnology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Georgios Valsamakis, Konstantinos Valtetsiotis, Evangelia Charmandari, Irene Lambrinoudaki, Nikolaos F. Vlahos
Summary: This review examines the use of Gonadotropin-releasing Hormone (GnRH) analogues as co-treatment for chemotherapy and radiotherapy. The ovarian suppressive effects of these analogues make them a potential option for treating infertility caused by these treatments. GnRH agonists have shown effectiveness in hematological and breast cancer treatment, while evidence for their use in ovarian endometrial and cervical cancers is limited. GnRH antagonists have a similar protective effect and may be preferred in cases where immediate treatment is necessary or when flare-up effects are contra-indicated. Combining agonists and antagonists has primarily been studied in animal models. More research is needed to determine their efficacy and impact on ovarian reserve and fertility outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Vasiliki Efthymiou, Evangelia Charmandari, Dimitrios Vlachakis, Artemis Tsitsika, Artur Palasz, George Chrousos, Flora Bacopoulou
Summary: Self-efficacy is an important factor in behavioral changes, particularly related to diet and exercise. This study aimed to examine the self-efficacy of Greek adolescents in these areas and how it can be improved through a school-based lifestyle intervention. The study found that the intervention significantly increased self-efficacy and reduced abdominal obesity in the adolescents. Additionally, those with higher diet quality scores demonstrated greater self-efficacy in diet and exercise.
Review
Nutrition & Dietetics
Diamanto Koutaki, George Paltoglou, Aikaterini Vourdoumpa, Evangelia Charmandari
Summary: This systematic review examines the impact of Bisphenol A (BPA) concentrations on thyroid function in neonates, children, and adolescents. The studies show a negative correlation between BPA concentrations and TSH in children, with potential gender-specific effects and impact on neurodevelopment. However, the findings on specific thyroid hormone concentrations and thyroid autoimmunity are inconclusive.
Article
Biochemistry & Molecular Biology
Nicolas C. Nicolaides, Manousos Makridakis, Rafael Stroggilos, Vasiliki Lygirou, Eleni Koniari, Ifigeneia Papageorgiou, Amalia Sertedaki, Jerome Zoidakis, Evangelia Charmandari
Summary: Significant inter-individual variation in susceptibility to stress-related disorders has been observed among healthy subjects. This study used proteomics analysis to identify molecular differences between glucocorticoid resistant and glucocorticoid sensitive subjects, and found that certain plasma proteins may play a role in chronic stress-related diseases. These findings have clinical implications and provide insight into the underlying mechanisms of these diseases.
Article
Pediatrics
Alexandra Georgiou, Odysseas Androutsos, Giorgos Chouliaras, Evangelia Charmandari
Summary: The study found that children and adolescents in Greece with overweight or obesity did not meet the national food-based dietary guidelines, particularly in terms of dairy products, fruits, vegetables, legumes, and fish consumption. Additionally, a significant number of participants regularly consumed unhealthy foods and beverages. New strategies to promote healthy eating habits for children and adolescents with overweight or obesity are urgently needed.
Article
Nutrition & Dietetics
Christina Raftopoulou, George Paltoglou, Evangelia Charmandari
Summary: This review summarizes the impact of childhood obesity on telomere length, revealing a negative association. Lifestyle interventions in children may lead to increased telomere length peripherally, suggesting a potential mechanistic relation worth further investigation.
Editorial Material
Nutrition & Dietetics
Odysseas Androutsos, Evangelia Charmandari
Article
Endocrinology & Metabolism
Christina Raftopoulou, Ozair Abawi, Grit Sommer, Maria Binou, George Paltoglou, Christa E. Flueck, Erica L. T. van den Akker, E. Charmandari
Summary: This study investigated the leukocyte telomere length (LTL) in children with congenital adrenal hyperplasia (CAH) who were treated with glucocorticoids. The results showed that LTL was shorter in patients with classic CAH compared to nonclassic CAH, and in those who were overtreated or treated with long-acting glucocorticoids. These findings suggest that LTL may serve as a biomarker for monitoring glucocorticoid treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Sofia Karampatsou, George Paltoglou, Sofia M. Genitsaridi, Penio Kassari, Evangelia Charmandari
Summary: This study demonstrates the association between FGF-23, osteopontin, NGAL and sclerostin with being overweight or obese, and their alteration in relation to changes in BMI. There is a crosstalk between adipose tissue and bone tissue, and these markers may play a role in glucose metabolism.
Article
Nutrition & Dietetics
Simon Toupance, Sofia I. Karampatsou, Carlos Labat, Sofia-Maria Genitsaridi, Athanasia Tragomalou, Penio Kassari, George Soulis, Allyson Hollander, Evangelia Charmandari, Athanase Benetos
Summary: In adults, short leukocyte telomere length (LTL) is associated with metabolic disorders, and this association may be influenced by early life interactions between LTL and metabolic disorders. In children, obesity and metabolic disturbances are associated with shorter telomeres, but not with more pronounced LTL attrition.
Review
Biochemistry & Molecular Biology
Konstantinos Valtetsiotis, Georgios Valsamakis, Evangelia Charmandari, Nikolaos F. Vlahos
Summary: Female infertility and reproduction issues are becoming more prevalent, leading to delayed family planning. This review examines potential metabolic mechanisms involved in ovarian aging and explores new medical treatments, including stem cell procedures, caloric restriction, hyperbaric oxygen treatment, and mitochondrial transfer. Understanding the connection between metabolism and reproduction could significantly advance the prevention of ovarian aging and extend female fertility. Overall, the field of ovarian aging has the potential to expand the fertility window and reduce the reliance on artificial reproductive techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Aikaterini Vourdoumpa, George Paltoglou, Evangelia Charmandari
Summary: Overweight and obesity in childhood and adolescence is a major public health problem, with genetic, epigenetic, and environmental factors influencing its development. This study reviewed evidence on the association between genetic variations and changes in body mass index (BMI) and body composition in overweight/obese children and adolescents undergoing multidisciplinary management. SNPs in 24 genetic loci were significantly associated with BMI and/or body composition changes, highlighting the role of genetic and molecular factors in the development of obesity.
Review
Nutrition & Dietetics
Galateia Stathori, Anastasia-Maria Tzounakou, George Mastorakos, Nikolaos F. Vlahos, Evangelia Charmandari, Georgios Valsamakis
Summary: The prevalence of central precocious puberty (CPP) in girls has been increasing worldwide and is often associated with childhood obesity and diet. Evidence suggests that girls with obesity have alterations in appetite-regulating hormones, potentially affecting the onset of puberty. Additionally, diet-induced hypothalamic inflammation may play a role in the pathophysiology of CPP, leading to changes in appetite-regulating hormones in young children.
Article
Pediatrics
Odysseas Androutsos, Thomas Tsiampalis, Matina Kouvari, Maria Manou, Maria Dimopoulou, Alexandra Georgiou, Rena I. Kosti, Evangelia Charmandari
Summary: This study aimed to assess the diet quality of a large cohort of children and adolescents with overweight or obesity. The results showed that more than half of the children had a high diet quality, but still, one-third of overweight children had poor diet quality. Boys and children living in urban areas had better diet quality, while younger children had lower diet quality. Therefore, targeted dietary interventions should be designed for this group.
