HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

(2021) Debra Van Egeren et al.   Cell Stem Cell

LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms

(2021) Christian Marinaccio et al.   Cancer Discovery

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

(2020) Bethan Psaila et al.   MOLECULAR CELL

DNA methylation disruption reshapes the hematopoietic differentiation landscape

(2020) Franco Izzo et al.   NATURE GENETICS

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera

(2020) Jerry L. Spivak et al.   PLoS One

PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

(2020) Friederike Pastore et al.   Cancer Discovery

Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden

(2020) Theodoros Karantanos et al.   Blood Advances

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

(2020) Erik L. Bao et al.   NATURE

Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?

(2020) Emery H. Bresnick et al.   Blood Advances

Phase 2 study of ruxolitinib and decitabine in patients with myeloproliferative neoplasm in accelerated and blast phase

(2020) John O. Mascarenhas et al.   Blood Advances

Clinical Insights into the Origins of Thrombosis in Myeloproliferative Neoplasms

(2020) Alison R. Moliterno et al.   BLOOD

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

(2020) Felix A. Dingler et al.   MOLECULAR CELL

Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence

(2020) Kristbjorn O. Gudmundsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applied genomics in MPN presentation

(2020) Alison R. Moliterno et al.   Hematology-American Society of Hematology Education Program

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing

(2019) Alba Rodriguez-Meira et al.   MOLECULAR CELL

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

(2019) Anna S. Nam et al.   NATURE

High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer

(2019) Mikhail Gorbounov et al.   BREAST CANCER RESEARCH AND TREATMENT

Myelofibrosis in 2019: moving beyond JAK2 inhibition

(2019) Michael Schieber et al.   Blood Cancer Journal

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells

(2019) Juan Bautista Menendez-Gonzalez et al.   Scientific Reports

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

(2018) Maria Kleppe et al.   CANCER CELL

Lessons from the Crypt: HMGA1—Amping up Wnt for Stem Cells and Tumor Progression

(2018) Linda Resar et al.   CANCER RESEARCH

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

(2018) Amir Giladi et al.   NATURE CELL BIOLOGY

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

(2018) Miriam Marquis et al.   Blood Cancer Journal

Classification and Personalized Prognosis in Myeloproliferative Neoplasms

(2018) Jacob Grinfeld et al.   NEW ENGLAND JOURNAL OF MEDICINE

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

(2017) Laure Gilles et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization

(2017) Christelle Freitas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic Risk Assessment in Myeloproliferative Neoplasms

(2017) Ayalew Tefferi et al.   MAYO CLINIC PROCEEDINGS

Myeloproliferative Neoplasms

(2017) Jerry L. Spivak   NEW ENGLAND JOURNAL OF MEDICINE

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

(2017) Lingling Xian et al.   Nature Communications

CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles

(2017) Roberta Zini et al.   Blood Cancer Journal

The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature

(2017) M Zingariello et al.   Blood Cancer Journal

Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia

(2016) Ilaria Iacobucci et al.   CANCER CELL

The High Mobility Group A1 ( HMGA1 ) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 ( MMP-2 ) in a subset of tumors

(2016) Joelle Hillion et al.   GYNECOLOGIC ONCOLOGY

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms

(2016) Jacob Grinfeld et al.   HAEMATOLOGICA

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms

(2016) Jacob Grinfeld et al.   HAEMATOLOGICA

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis

(2014) A. Tefferi et al.   BLOOD

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

(2014) P. Lundberg et al.   BLOOD

JAK2V617F somatic mutation in the general population: myeloproliferative neoplasm development and progression rate

(2014) C. Nielsen et al.   HAEMATOLOGICA

Two Clinical Phenotypes in Polycythemia Vera

(2014) Jerry L. Spivak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivation of theCdkn2alocus cooperates withHMGA1to drive T-cell leukemogenesis

(2013) Francescopaolo Di Cello et al.   LEUKEMIA & LYMPHOMA

HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia

(2013) Sujayita Roy et al.   LEUKEMIA & LYMPHOMA

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

The HMGA1-COX-2 axis: A key molecular pathway and potential target in pancreatic adenocarcinoma

(2013) Joelle Hillion et al.   PANCREATOLOGY

HMGA1: A Master Regulator of Tumor Progression in Triple-Negative Breast Cancer Cells

(2013) Sandeep N. Shah et al.   PLoS One

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

(2012) S. L. Maude et al.   BLOOD

Flow cytometry analysis of murine hematopoietic stem cells

(2012) Allison Mayle et al.   CYTOMETRY PART A

HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells

(2012) Amy Belton et al.   PLoS One

HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks

(2012) Sandeep N. Shah et al.   PLoS One

Higher order chromatin organization in cancer

(2012) Karen L. Reddy et al.   SEMINARS IN CANCER BIOLOGY

Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias

(2011) J. E. Karp et al.   BLOOD

3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice

(2011) K. Ikeda et al.   BLOOD

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

(2011) Andrew Schuldenfrei et al.   BMC GENOMICS

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

(2011) Bin-Kuan Chou et al.   CELL RESEARCH

Flavopiridol inducesBCL-2expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia

(2011) Dwella M. Nelson et al.   LEUKEMIA & LYMPHOMA

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

(2010) H. Akada et al.   BLOOD

The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer?

(2010) L. M.S. Resar   CANCER RESEARCH

Hereditary myeloproliferative disorders

(2010) R. C. Skoda   HAEMATOLOGICA

HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma

(2009) Alexandra C Hristov et al.   MODERN PATHOLOGY

GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1

(2009) Z. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Upregulation of MMP-2 by HMGA1 Promotes Transformation in Undifferentiated, Large-Cell Lung Cancer

(2009) J. Hillion et al.   MOLECULAR CANCER RESEARCH

The natural history and treatment outcome of blast phase BCR-ABL- myeloproliferative neoplasms

(2008) C. S. Tam et al.   BLOOD

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice

(2008) S. Xing et al.   BLOOD

The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

(2008) J. Hillion et al.   CANCER RESEARCH

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS