Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies
出版年份 2022 全文链接
标题
Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies
作者
关键词
-
出版物
BIOTECHNOLOGY AND BIOENGINEERING
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2022-04-26
DOI
10.1002/bit.28120
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand
- (2022) Julia Scheffel et al. JOURNAL OF CHROMATOGRAPHY A
- Pilot‐scale demonstration of an end‐to‐end integrated and continuous biomanufacturing process
- (2021) Michael J. Coolbaugh et al. BIOTECHNOLOGY AND BIOENGINEERING
- An integrated continuous downstream process with real‐time control: A case study with periodic countercurrent chromatography and continuous virus inactivation
- (2021) Anton Löfgren et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process development and optimization of continuous capture with three‐column periodic counter‐current chromatography
- (2021) Ce Shi et al. BIOTECHNOLOGY AND BIOENGINEERING
- A Common Framework for Integrated and Continuous Biomanufacturing
- (2021) Jonathan Coffman et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch
- (2021) Sigrid Särnlund et al. BIOTECHNOLOGY AND BIOENGINEERING
- Side‐by‐side comparability of batch and continuous downstream for the production of monoclonal antibodies
- (2020) Laura David et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies
- (2020) Fabian Feidl et al. BIOTECHNOLOGY AND BIOENGINEERING
- Model-based design and control of a small-scale integrated continuous end-to-end mAb platform
- (2020) Joaquín Gomis-Fons et al. BIOTECHNOLOGY PROGRESS
- Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics
- (2020) Heliang Li et al. Cellular & Molecular Immunology
- Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process
- (2020) Joaquín Gomis-Fons et al. JOURNAL OF CHROMATOGRAPHY A
- Optimal loading flow rate trajectory in monoclonal antibody capture chromatography
- (2020) Joaquín Gomis-Fons et al. JOURNAL OF CHROMATOGRAPHY A
- Highly selective Protein A resin allows for mild sodium chloride-mediated elution of antibodies
- (2020) Julia Scheffel et al. JOURNAL OF CHROMATOGRAPHY A
- Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE
- (2020) Liang Zhang et al. METABOLIC ENGINEERING
- Continuous solvent/detergent virus inactivation using a packed-bed reactor
- (2019) Duarte L. Martins et al. Biotechnology Journal
- Integration of a complete downstream process for the automated lab-scale production of a recombinant protein
- (2019) Joaquín Gomis Fons et al. JOURNAL OF BIOTECHNOLOGY
- Optimization of a calcium-dependent Protein A-derived domain for mild antibody purification
- (2019) Julia Scheffel et al. mAbs
- Small-scale bioreactor supports high density HEK293 cell perfusion culture for the production of recombinant Erythropoietin
- (2019) Hubert Schwarz et al. JOURNAL OF BIOTECHNOLOGY
- Single pass diafiltration integrated into a fully continuous mAb purification process
- (2018) Joanna Rucker-Pezzini et al. BIOTECHNOLOGY AND BIOENGINEERING
- Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm
- (2018) Lindsay Arnold et al. Biotechnology Journal
- Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies
- (2018) Sara Kanje et al. JOURNAL OF MOLECULAR BIOLOGY
- Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation for optimum resin utilization and productivity
- (2018) Mark-Henry Kamga et al. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm
- (2018) Lindsay Arnold et al. Biotechnology Journal
- Effective strategies for host cell protein clearance in downstream processing of monoclonal antibodies and Fc-fusion proteins
- (2017) Yifeng Li PROTEIN EXPRESSION AND PURIFICATION
- Acid-induced aggregation propensity of nivolumab is dependent on the Fc
- (2016) Boning Liu et al. mAbs
- Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture
- (2015) Daniel Baur et al. Biotechnology Journal
- Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor
- (2015) Ye Zhang et al. JOURNAL OF BIOTECHNOLOGY
- The business impact of an integrated continuous biomanufacturing platform for recombinant protein production
- (2015) Jason Walther et al. JOURNAL OF BIOTECHNOLOGY
- End-to-end integrated fully continuous production of recombinant monoclonal antibodies
- (2015) Rahul Godawat et al. JOURNAL OF BIOTECHNOLOGY
- Developing the biofacility of the future based on continuous processing and single-use technology
- (2015) Stephan Klutz et al. JOURNAL OF BIOTECHNOLOGY
- Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture
- (2015) Daniel Baur et al. Biotechnology Journal
- Characterization and Stability Study of Polysorbate 20 in Therapeutic Monoclonal Antibody Formulation by Multidimensional Ultrahigh-Performance Liquid Chromatography–Charged Aerosol Detection–Mass Spectrometry
- (2014) Yi Li et al. ANALYTICAL CHEMISTRY
- Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™-part II: Applications for antibody production and cryopreservation
- (2013) Marie-Françoise Clincke et al. BIOTECHNOLOGY PROGRESS
- Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process
- (2013) Marie-Françoise Clincke et al. BIOTECHNOLOGY PROGRESS
- Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress
- (2013) Takahiko Ito et al. PROTEIN SCIENCE
- Integrated continuous production of recombinant therapeutic proteins
- (2012) Veena Warikoo et al. BIOTECHNOLOGY AND BIOENGINEERING
- Periodic counter-current chromatography - design and operational considerations for integrated and continuous purification of proteins
- (2012) Rahul Godawat et al. Biotechnology Journal
- Aggregates in monoclonal antibody manufacturing processes
- (2011) María Vázquez-Rey et al. BIOTECHNOLOGY AND BIOENGINEERING
- Technology trends in antibody purification
- (2011) Pete Gagnon JOURNAL OF CHROMATOGRAPHY A
- Acid-Induced Aggregation of Human Monoclonal IgG1 and IgG2: Molecular Mechanism and the Effect of Solution Composition
- (2010) Sanjay B. Hari et al. BIOCHEMISTRY
- DNA spike studies for demonstrating improved clearance on chromatographic media
- (2009) Michelle D. Butler et al. JOURNAL OF CHROMATOGRAPHY A
- Robustness of solvent/detergent treatment of plasma derivatives: a data collection from Plasma Protein Therapeutics Association member companies
- (2009) Herbert O. Dichtelmüller et al. TRANSFUSION
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started