Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets

(2021) Antonino Lauria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise

(2021) Noura Khaiwa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells – involvement of carbonyl reductase 1

(2020) Paulina Koczurkiewicz-Adamczyk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Trastuzumab-deruxtecan: an investigational agent for the treatment of HER2-positive breast cancer

(2020) Rupert Bartsch   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery

(2019) Ying Qu et al.   JOURNAL OF CONTROLLED RELEASE

Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poisons with Potent Anticancer Activity

(2019) Biswajit Kundu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibody-drug conjugates of 7-ethyl-10-hydroxycamptothecin: Sacituzumab govitecan and labetuzumab govitecan

(2019) Wenjuan Dong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

(2019) Xiaoxia Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study

(2019) Kenji Tamura et al.   LANCET ONCOLOGY

RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1

(2019) Chengxiang Lian et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin

(2019) Cheng-Jie Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer

(2019) Shanu Modi et al.   NEW ENGLAND JOURNAL OF MEDICINE

New cinnamic acid-pregenolone hybrids as potential antiproliferative agents: Design, synthesis and biological evaluation

(2019) Yong-Xi Ge et al.   STEROIDS

(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

(2019) Mengqiu Song et al.   Cancers

Trans -cinnamic acid attenuates UVA-induced photoaging through inhibition of AP-1 activation and induction of Nrf2-mediated antioxidant genes in human skin fibroblasts

(2018) You-Cheng Hseu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes

(2018) Subhendu K. Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer

(2018) Afroz S. Mohammad et al.   PHARMACEUTICAL RESEARCH

Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo

(2018) Hongzhi Du et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enzymatic modification of chitosan by cinnamic acids: Antibacterial activity against Ralstonia solanacearum

(2016) Caifeng Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids

(2015) Linhu Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Perspectives on Biologically Active Camptothecin Derivatives

(2015) Ying-Qian Liu et al.   MEDICINAL RESEARCH REVIEWS

Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38

(2013) Vaskor Bala et al.   JOURNAL OF CONTROLLED RELEASE

A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors

(2013) Zhenyuan Miao et al.   JOURNAL OF MEDICINAL CHEMISTRY

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

(2010) Yong Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antitumor Agents 286. Design, Synthesis, and Structure−Activity Relationships of 3′R,4′R-Disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DSP) Analogues as Potent Chemosensitizers to Overcome Multidrug Resistance

(2010) Ting Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Development of Novel Camptothecin Drugs

(2008) Siong Liew et al.   CURRENT PHARMACEUTICAL DESIGN

Next generation topoisomerase I inhibitors: Rationale and biomarker strategies

(2007) Beverly A. Teicher   BIOCHEMICAL PHARMACOLOGY