Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models

Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics

(2022) Aleksandra M. Juszczak et al.   MEDICINAL RESEARCH REVIEWS

Dauricine inhibits proliferation and promotes death of melanoma cells via inhibition of Src/ STAT3 signaling

(2021) Bo Deng et al.   PHYTOTHERAPY RESEARCH

Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway

(2020) Keitaro Iida et al.   CANCER SCIENCE

Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial–Mesenchymal Transition

(2020) Wook Jin   Cells

An Economic Evaluation of Pembrolizumab Versus Other Adjuvant Treatment Strategies for Resected High-Risk Stage III Melanoma in the USA

(2020) Arielle G. Bensimon et al.   CLINICAL DRUG INVESTIGATION

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression

(2020) Xiu-Qiong Fu et al.   Cell Death & Disease

Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

(2020) Sagie Brodsky et al.   MOLECULAR CELL

HIF-1α/VEGF signaling-mediated epithelial-mesenchymal transition and angiogenesis is critically involved in anti-metastasis effect of luteolin in melanoma cells

(2019) Chunyu Li et al.   PHYTOTHERAPY RESEARCH

Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment

(2019) Qian Yu et al.   Cell Death & Disease

Identification of a Novel Quinoxaline-Isoselenourea Targeting the STAT3 Pathway as a Potential Melanoma Therapeutic

(2019) Verónica Alcolea et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioavailability and Pharmaco-therapeutic potential of luteolin in overcoming Alzheimer`s disease

(2019) Fahad Ali et al.   CNS & Neurological Disorders-Drug Targets

MnFe2O4 nanoparticles accelerate the clearance of mutant huntingtin selectively through ubiquitin-proteasome system

(2019) Li Zhang et al.   BIOMATERIALS

Risks of Melanoma and Other Cancers in Melanoma-Prone Families over 4 Decades

(2018) Margaret A. Tucker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stereotactic radiosurgery and ipilimumab for patients with melanoma brain metastases: clinical outcomes and toxicity

(2018) Kevin Diao et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Melanoma Chemoprevention: Current Status and Future Prospects

(2017) Gagan Chhabra et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane

(2016) Yan Yang et al.   NEUROREPORT

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

(2015) Michinori Ogura et al.   CANCER SCIENCE

Phase 1 and pharmacological trial of OPB-31121, a signal transducer and activator of transcription-3 inhibitor, in patients with advanced hepatocellular carcinoma

(2015) Takuji Okusaka et al.   HEPATOLOGY RESEARCH

Absorption and Metabolism of Luteolin and Its Glycosides from the Extract of Chrysanthemum morifolium Flowers in Rats and Caco-2 Cells

(2015) Michiko Torii Yasuda et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats

(2015) Lie-Chwen Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells

(2015) Xince Huang et al.   OncoTargets and Therapy

Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets

(2015) Giuseppe Palmieri et al.   Frontiers in Oncology

Luteolin Arrests Cell Cycling, Induces Apoptosis and Inhibits the JAK/STAT3 Pathway in Human Cholangiocarcinoma Cells

(2014) Ploypailin Aneknan et al.   Asian Pacific Journal of Cancer Prevention

Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3

(2014) Mon-Yuan Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nutrition: The future of melanoma prevention?

(2014) Lana X. Tong et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Comparative Studies to Evaluate Relative in vitro Potency of Luteolin in Inducing Cell Cycle Arrest and Apoptosis in HaCaT and A375 Cells

(2013) Vazhapilly Cijo George et al.   Asian Pacific Journal of Cancer Prevention

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling

(2013) Hui-Hui Cao et al.   BIOCHEMICAL PHARMACOLOGY

The potential for targeting the STAT3 pathway as a novel therapy for melanoma

(2013) Gregory B Lesinski   Future Oncology

Downregulation of Stat3 in melanoma: reprogramming the immune microenvironment as an anticancer therapeutic strategy

(2013) P U Emeagi et al.   GENE THERAPY

Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition

(2012) Jun-shan Ruan et al.   ACTA PHARMACOLOGICA SINICA

The determination and interpretation of the therapeutic index in drug development

(2012) Patrick Y. Muller et al.   NATURE REVIEWS DRUG DISCOVERY

The Flavonoid Luteolin Inhibits Fcγ-Dependent Respiratory Burst in Granulocytes, but Not Skin Blistering in a New Model of Pemphigoid in Adult Mice

(2012) Eva Oswald et al.   PLoS One

Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3

(2012) Jin Fu et al.   PLoS One

Luteolin Inhibits Protein Kinase C  and c-Src Activities and UVB-Induced Skin Cancer

(2010) S. Byun et al.   CANCER RESEARCH

Bioavailability Challenges Associated with Development of Anti-Cancer Phenolics

(2010) S. Gao et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Intestinal Absorption of Luteolin from Peanut Hull Extract Is More Efficient than That from Individual Pure Luteolin

(2007) Ping Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY