Identification of a Novel Quinoxaline-Isoselenourea Targeting the STAT3 Pathway as a Potential Melanoma Therapeutic

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity

(2017) Deepkamal N. Karelia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chalcogen containing heterocyclic scaffolds: New hybrids with antitumoral activity

(2016) Verónica Alcolea et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines

(2016) Verónica Alcolea et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Selenium compounds as therapeutic agents in cancer

(2015) Aristi P. Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Targeting drivers of melanoma with synthetic small molecules and phytochemicals

(2015) Leah Ray Strickland et al.   CANCER LETTERS

The use of interferon in melanoma patients: A systematic review

(2015) Rossella Di Trolio et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Melanoma Treatments: Advances and Mechanisms

(2015) Alexander Marzuka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells

(2015) Nabanita Mukherjee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Critical role of STAT3 in melanoma metastasis through anoikis resistance

(2015) Neel M. Fofaria et al.   Oncotarget

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

(2014) Kodappully Sivaraman Siveen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Stat3-Targeted Therapies Overcome the Acquired Resistance to Vemurafenib in Melanomas

(2013) Fang Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design

(2013) Wenying Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

(2013) T M Becker et al.   ONCOGENE

Mechanism of the inhibition of the STAT3 signaling pathway by EGCG

(2013) YANG WANG et al.   ONCOLOGY REPORTS

Selenium for the Prevention of Cutaneous Melanoma

(2013) Pamela Cassidy et al.   Nutrients

Is Selenium a Potential Treatment for Cancer Metastasis?

(2013) Yu-Chi Chen et al.   Nutrients

Cytotoxic and Proapototic Activities of Imidoselenocarbamate Derivatives Are Dependent on the Release of Methylselenol

(2012) Alicia Zuazo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

(2012) Maria R. Girotti et al.   Cancer Discovery

Melanoma Prevention Using Topical PBISe

(2011) C.-Y. Chung et al.   Cancer Prevention Research

Melanoma Chemoprevention in Skin Reconstructs and Mouse Xenografts Using Isoselenocyanate-4

(2010) N. Nguyen et al.   Cancer Prevention Research

Synthesis and antiproliferative activity of novel symmetrical alkylthio- and alkylseleno-imidocarbamates

(2010) Elena Ibáñez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis

(2010) G. Ishdorj et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Akt3 Signaling in Malignant Melanoma Using Isoselenocyanates

(2009) A. Sharma et al.   CLINICAL CANCER RESEARCH

Synthesis and Anticancer Activity Comparison of Phenylalkyl Isoselenocyanates with Corresponding Naturally Occurring and Synthetic Isothiocyanates

(2008) Arun K. Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selenium Compounds and Apoptotic Modulation: A New Perspective in Cancer Therapy

(2008) Carmen Sanmartin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

PBISe, a novel selenium-containing drug for the treatment of malignant melanoma

(2008) S. V. Madhunapantula et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, synthesis, and studies of small molecule STAT3 inhibitors

(2007) Deepak Bhasin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS