Rapid Surface Display of mRNA Antigens by Bacteria‐Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine

How COVID unlocked the power of RNA vaccines

(2021) Elie Dolgin   NATURE

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

(2021) Di Yin et al.   NATURE BIOTECHNOLOGY

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

(2021) Eryn Blass et al.   Nature Reviews Clinical Oncology

Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice

(2021) Sikai Ling et al.   Nature Biomedical Engineering

Development of a Cancer Vaccine Using In Vivo Click‐Chemistry‐Mediated Active Lymph Node Accumulation for Improved Immunotherapy

(2021) Hao Qin et al.   ADVANCED MATERIALS

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

(2021) Keman Cheng et al.   Nature Communications

Multifunctional biomolecule nanostructures for cancer therapy

(2021) Jing Wang et al.   Nature Reviews Materials

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

(2021) Long Chen et al.   Science Translational Medicine

A Hybrid Eukaryotic-Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

(2020) Qi Chen et al.   ADVANCED MATERIALS

The promise of mRNA vaccines: a biotech and industrial perspective

(2020) Nicholas A. C. Jackson et al.   npj Vaccines

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

(2020) Qianqian Ni et al.   Science Advances

RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting

(2020) Shuo Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

(2020) Yao Li et al.   ACS Nano

Long-range RNA structural information via a paramagnetically tagged reporter protein

(2019) Madeleine Strickland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lymph node conduits transport virions for rapid T cell activation

(2019) Glennys V. Reynoso et al.   NATURE IMMUNOLOGY

Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery

(2019) Naoto Yoshinaga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

(2019) Wei Peng et al.   PLoS One

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET

(2019) Nhan Huynh et al.   Nature Communications

Evaluation of novel cationic gene based liposomes with cyclodextrin prepared by thin film hydration and microfluidic systems

(2019) Hassan Elsana et al.   Scientific Reports

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

(2018) Ryosuke Kojima et al.   Nature Communications

An RNA toolbox for cancer immunotherapy

(2018) Fernando Pastor et al.   NATURE REVIEWS DRUG DISCOVERY

Lipid Nanovesicles by Microfluidics: Manipulation, Synthesis, and Drug Delivery

(2018) Chao Liu et al.   ADVANCED MATERIALS

The role of RNA structure in translational regulation by L7Ae protein in archaea

(2018) Lin Huang et al.   RNA

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

(2017) Oh Youn Kim et al.   Nature Communications

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice

(2016) C. Garrett Rappazzo et al.   VACCINE

Efficient expression of stabilized mRNA PEG-peptide polyplexes in liver

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Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy

(2014) Vipul Gujrati et al.   ACS Nano

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Structure of a rare non-standard sequence k-turn bound by L7Ae protein

(2014) Lin Huang et al.   NUCLEIC ACIDS RESEARCH

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

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MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

(2012) J. K. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Listeriolysin O: the Swiss army knife of Listeria

(2012) Mélanie Anne Hamon et al.   TRENDS IN MICROBIOLOGY

pH dependence of listeriolysin O aggregation and pore-forming ability

(2011) Andrej Bavdek et al.   FEBS Journal

RNAIII activatesmapexpression by forming an RNA-RNA complex inStaphylococcus aureus

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Essential role of Toll-like receptor 2 in macrophage activation by glycogen

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Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming

(2011) Dong Ho Lee et al.   VACCINE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism

(2009) Marcus Mueller et al.   NATURE

Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality

(2008) Jae-Young Kim et al.   JOURNAL OF MOLECULAR BIOLOGY