Article
Chemistry, Multidisciplinary
Lingling Shang, Yonggan Yan, Zhao Li, Hong Liu, Shaohua Ge, Baojin Ma
Summary: A natural hemostatic powder that can rapidly self-gel to form adhesive is developed, which possesses multiple functions and can adhere to various surfaces for in situ sealing and rapid hemostasis. Additionally, the powder exhibits good antibacterial and inhibiting biofilm formation ability, and can promote wound repair by regulating immune response.
Article
Chemistry, Multidisciplinary
Chunyan Cui, Yage Sun, Xiongfeng Nie, Xuxuan Yang, Fushuo Wang, Wenguang Liu
Summary: Researchers created a self-stabilized deep eutectic supramolecular polymer adhesive called LA-DESP by heating a mixture of LA and LA-Na, which can sustainably release bioactive small molecules with antioxidant and antibacterial functions. The adhesive shows fast and strong adhesion to various substrates, including wet tissues. This study provides a new strategy for developing LA-based bioadhesives.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Shujun Cao, Gan Xu, Qiujing Li, Shukun Zhang, Yifan Yang, Jingdi Chen
Summary: In this study, an elastic and biodegradable wound dressing with antibacterial and hemostatic properties was designed and its potential clinical application was demonstrated through in vitro and in vivo experiments.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Environmental
Na Xu, Yuanping Gao, Zheng Li, Yu Chen, Menglong Liu, Jiezhi Jia, Rui Zeng, Gaoxing Luo, Jiangfeng Li, Yunlong Yu
Summary: Diabetic wound management faces challenges due to immune disorders. Targeted regulation of macrophage polarization could be a useful approach. The synthesized composite hydrogel showed good mechanical properties and antibacterial capacity, and promoted wound healing through anti-inflammation and pro-angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Yuanhua Zhang, Rongheng Chen, Li He, Xiaofei Wang, Dengjiang Wu, Yulin Lin, Mao Ye, Zhaoyin Zhu, Zhigang Chen, Yingping Jiang, Weijian Chen
Summary: Traditional dressings often have difficulties in closing and repairing irregular wounds, while injectable hydrogels that can be molded in situ offer advantages in treating complex and large wounds. However, most injectable hydrogels developed in current research have limitations in mechanical properties, biocompatibility, and clinical applications. This paper reports an injectable hydrogel with appropriate mechanical properties, excellent biocompatibility, and antibacterial activity.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hafez Jafari, Pejman Ghaffari-Bohlouli, Mohsen Alishahi, Farideh Davani, Seyyed Sajad Daneshi, Reza Heidari, Mohammad Hossein Morowvat, Seyyed Vahid Niknezhad, Lei Nie, Houman Savoji, Amin Shavandi
Summary: This study investigates the potential of using keratin and silk as natural structural proteins for designing tissue adhesives for wound healing. Through the utilization of polyphenol chemistry, the study demonstrates the silk-wool-tannic acid (SF-Wool-TA) complex as an in situ tissue adhesive. The SF-Wool-TA hydrogel exhibits various desirable properties, such as in situ gelation, recyclability, moldability, elasticity, adhesiveness, and self-healing, and has shown improved wound healing in vivo.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Yi-Ming Gao, Zi-Yuan Li, Xiao-Jie Zhang, Junji Zhang, Qing-Feng Li, Shuang-Bai Zhou
Summary: Inventions of materials with biocompatibility, bioadhesion, and easy manufacturing are urgently needed for wound healing in clinical treatment. This study reports the fabrication of a hybrid double-network polydopamine-HA (PDA-HA) hydrogel with enhanced adhesiveness compared to HA hydrogel. The PDA-HA hydrogel can be vacuum-dried to form a patch for convenient storage and distribution. When applied on wounds, the PDA-HA patch quickly rehydrates and tightly adheres to the wound, promoting wound healing and increasing healing rates.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Juan Zhou, Yanzhe Wu, Xihe Zhang, Jiahui Lai, Yuanli Li, Jian Xing, Liping Teng, Jinghua Chen
Summary: The GTT-3 hydrogel, developed as a versatile bioadhesive, possesses biocompatibility, adhesion, hemostasis, and therapeutic properties that promote wound healing through efficient integration and adhesion to tissue via chemical reactions, providing a new option for surgical operations.
Article
Engineering, Biomedical
Deyan Du, Xi Chen, Chang Shi, Zhuying Zhang, Dongjian Shi, Daisaku Kaneko, Tatsuo Kaneko, Zhen Hua
Summary: In this study, mussel-inspired epoxy bioadhesives (CSD-PEG) were successfully synthesized and exhibited high mechanical and adhesion strengths, making them promising candidates for surgical tissue repair, wound closure, and tissue engineering applications. Multiple interfacial interactions between the epoxy and catechol groups played a key role in enhancing the performance of the bioadhesives while maintaining favorable biocompatibility in vivo.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Xiuxia Wang, Hongyu Li, Fanling Meng, Liang Luo
Summary: The study developed an adhesive nanoparticle-based drug delivery system for locoregional photothermal and antiangiogenic cancer therapy. The nanoparticles showed super adhesion, antiangiogenesis, and efficient cellular uptake, leading to a synergistic antitumor effect in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nanoscience & Nanotechnology
Xinyue Wang, Hongjian Huang, Renfeng Xu, Yan Fang, Yunxiang Weng, Zhengchao Wang, Xiaopeng Xiong, Haiqing Liu
Summary: A strong and adhesive hydrogel for wet tissue adhesion was developed using modified tannic acid and polyethylenimine. The hydrogel exhibited excellent mechanical properties, wet tissue interfacial toughness, and could quickly and effectively adhere to various wet biological tissues.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Keke Wu, Xiaoxian Wu, Jinshan Guo, Yanpeng Jiao, Changren Zhou
Summary: A functional wound dressing was fabricated using polyphenol-europium ion assembly, showing abilities to improve wound microenvironment, scavenge ROS, and promote angiogenesis. In vitro and in vivo experiments confirmed its antioxidant properties, cell adhesion and proliferation-promoting effects, as well as angiogenesis stimulation abilities. This novel dressing holds promise for accelerated wound healing.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Applied
Zongbao Zhou, Jiangwei Xiao, Shuwen Guan, Zhijie Geng, Ruifang Zhao, Botao Gao
Summary: A curdlan-tannic acid hybrid hydrogel was successfully fabricated through the annealing technique, which exhibited excellent physicochemical properties and showed no significant cytotoxicity to cells. In vivo experiments proved that the multifunctional hydrogel could accelerate wound healing.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Yuxuan Yang, Xiaodan Zhao, Jing Yu, Xingxing Chen, Ruyue Wang, Mengyuan Zhang, Qiang Zhang, Yanfeng Zhang, Shuang Wang, Yilong Cheng
Summary: In this study, a bioactive skin-mimicking hydrogel band-aid was developed to promote the recovery of skin incision and defects on diabetic mice. The hydrogel showed promising anti-inflammation, antibacterial, and antioxidant properties, as well as moisture-resistant adhesiveness.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ines Guimaraes, Raquel Costa, Sara Madureira, Sandra Borges, Ana L. Oliveira, Manuela Pintado, Sara Baptista-Silva
Summary: Difficult-to-treat infections make complex wounds a problem of great clinical and socio-economic impact. Phytochemicals are promising alternatives for wound care, with antimicrobial and antioxidant activities. Chitosan-based microparticles were developed as carriers of tannic acid to improve its stability, bioavailability, and delivery. These microparticles showed high encapsulation efficiency, antimicrobial potential against common wound pathogens, and improved cell viability and proliferation compared to free tannic acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)