Neuroprotective and Therapeutic Strategies against Parkinson’s Disease: Recent Perspectives

Mesenchymal Stem Cells of Dental Origin-Their Potential for Antiinflammatory and Regenerative Actions in Brain and Gut Damage

(2016) Anna Földes et al.   Current Neuropharmacology

Development of stem cell-based therapies for Parkinson's disease

(2016) Bangfu Zhu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models

(2016) Kari Pollock et al.   MOLECULAR THERAPY

Developing Stem Cell Therapies for Parkinson’s Disease: Waiting Until the Time Is Right

(2014) Roger A. Barker   Cell Stem Cell

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model

(2014) Sumit Sarkar et al.   NEUROTOXICOLOGY

The ReSPonD trial - rivastigmine to stabilise gait in Parkinson’s disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson’s disease who have fallen

(2013) Emily J Henderson et al.   BMC Neurology

Mesenchymal stem cells and neuroregeneration in Parkinson's disease

(2013) Aleksandra Glavaski-Joksimovic et al.   EXPERIMENTAL NEUROLOGY

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

The promises of stem cells: stem cell therapy for movement disorders

(2013) Hideki Mochizuki et al.   PARKINSONISM & RELATED DISORDERS

Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model

(2013) Syed Z. Imam et al.   PLoS One

Explaining why Gleevec is a specific and potent inhibitor of Abl kinase

(2013) Y.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress in Stem Cell Therapy for Major Human Neurological Disorders

(2013) P. L. Martínez-Morales et al.   Stem Cell Reviews and Reports

Molecular Events Underlying Parkinson’s Disease – An Interwoven Tapestry

(2013) Kah-Leong Lim et al.   Frontiers in Neurology

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease

(2012) Patricia Mathieu et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials

(2012) Lorraine V. Kalia et al.   MOVEMENT DISORDERS

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Striatal Mechanisms Underlying Movement, Reinforcement, and Punishment

(2012) Alexxai V. Kravitz et al.   PHYSIOLOGY

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

(2011) J. Wang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

(2011) Karin Wirdefeldt et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

(2011) Yong-Hee Rhee et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

(2011) S. Z. Imam et al.   JOURNAL OF NEUROSCIENCE

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Parkinson’s disease: The non-motor issues

(2011) K. Ray Chaudhuri et al.   PARKINSONISM & RELATED DISORDERS

ES cell-derived renewable and functional midbrain dopaminergic progenitors

(2011) S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on the use of pramipexole in the treatment of Parkinson’s disease

(2011) Radu Constantinescu   Neuropsychiatric Disease and Treatment

Clinical review of treatment options for select nonmotor symptoms of Parkinson's disease

(2010) Lindy D. Wood et al.   American Journal Geriatric Pharmacotherapy

Nonmotor Symptoms in Genetic Parkinson Disease

(2010) Meike Kasten et al.   ARCHIVES OF NEUROLOGY

Deep Brain Stimulation for Parkinson Disease

(2010) Jeff M. Bronstein et al.   ARCHIVES OF NEUROLOGY

Olfaction as a biomarker in Parkinson’s disease

(2010) James F Morley et al.   Biomarkers in Medicine

Gene Therapy in Parkinsonʼs Disease

(2010) Li Rebekah Feng et al.   CNS DRUGS

Clinical Review and Treatment of Select Adverse Effects of Dopamine Receptor Agonists in Parkinsonʼs Disease

(2010) Lindy D. Wood   DRUGS & AGING

Using ‘omics’ to define pathogenesis and biomarkers of Parkinson’s disease

(2010) W Michael Caudle et al.   Expert Review of Neurotherapeutics

VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson’s disease

(2010) N Xiong et al.   GENE THERAPY

Premotor Parkinson's disease: Clinical features and detection strategies

(2010) Randolph Stephenson et al.   MOVEMENT DISORDERS

Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

(2010) Elena Moro et al.   MOVEMENT DISORDERS

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

(2010) Jia-Yi Li et al.   MOVEMENT DISORDERS

The nonmotor symptoms of Parkinson's disease-An overview

(2010) Shen-Yang Lim et al.   MOVEMENT DISORDERS

Treatment of the nonmotor symptoms of Parkinson disease

(2010) Werner Poewe   Nature Reviews Neurology

Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease

(2010) K. A. Chung et al.   NEUROLOGY

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell-derived dopamine neurons for brain repair in Parkinson’s disease

(2010) Rosemary A Fricker-Gates et al.   Regenerative Medicine

Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

(2010) M. Politis et al.   Science Translational Medicine

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: The COMPARE Trial

(2009) Michael S. Okun et al.   ANNALS OF NEUROLOGY

Abnormal serum concentrations of proteins in Parkinson’s disease

(2009) Ira L. Goldknopf et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Olfactory dysfunction as a diagnostic marker for Parkinson’s disease

(2009) Antje Haehner et al.   Expert Review of Neurotherapeutics

Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease

(2009) Lalitha Madhavan et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Impact of STN-DBS on life and health satisfaction in patients with Parkinson's disease

(2009) J. Ferrara et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The role of DAT-SPECT in movement disorders

(2009) G Kagi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease

(2009) S S Williams et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson's Disease

(2009) H. M. M. Smeding et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Biopsies of olfactory epithelium in patients with Parkinson's disease

(2009) Martin Witt et al.   MOVEMENT DISORDERS

Etiology and Pathogenesis of Parkinson Disease

(2009) Anthony H.V. Schapira   NEUROLOGIC CLINICS

Continuous dopaminergic stimulation achieved by duodenal levodopa infusion

(2009) Per Odin et al.   NEUROLOGICAL SCIENCES

A new sensitive imaging biomarker for Parkinson disease?

(2009) A. E. Lang et al.   NEUROLOGY

Can we image premotor Parkinson disease?

(2009) K. Marek et al.   NEUROLOGY

Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease

(2009) A. H.V. Schapira   NEUROLOGY

"Disease-modification" trials in Parkinson disease: Target populations, endpoints and study design

(2009) O. Rascol   NEUROLOGY

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

(2009) C. W. Christine et al.   NEUROLOGY

Neuroprotection in Parkinson's disease

(2009) Anthony H.V. Schapira   PARKINSONISM & RELATED DISORDERS

Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases

(2009) David S. Goldstein et al.   PARKINSONISM & RELATED DISORDERS

Dopamine Gene Therapy for Parkinson's Disease in a Nonhuman Primate Without Associated Dyskinesia

(2009) B. Jarraya et al.   Science Translational Medicine

Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease

(2009) Olle Lindvall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diet, Urate, and Parkinson's Disease Risk in Men

(2008) X. Gao et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Serum Urate as a Predictor of Clinical and Radiographic Progression in Parkinson Disease

(2008) Michael A. Schwarzschild   ARCHIVES OF NEUROLOGY

Targets for neuroprotection in Parkinson's disease

(2008) Talene A. Yacoubian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

(2008) M. Bogdanov et al.   BRAIN

A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease

(2008) Valerie Voon et al.   BRAIN

Targeting the caudal intralaminar nuclei for functional neurosurgery of movement disorders

(2008) Alim Louis Benabid   BRAIN RESEARCH BULLETIN

Prospective randomized 1-year follow-up comparison of bilateral subthalamotomy versus bilateral subthalamic stimulation and the combination of both in Parkinson's disease patients: a pilot study

(2008) M. Merello et al.   BRITISH JOURNAL OF NEUROSURGERY

Nilotinib: A second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia

(2008) David L. DeRemer et al.   CLINICAL THERAPEUTICS

The search for biomarkers in Parkinson’s disease: a critical review

(2008) Chrystalina A Antoniades et al.   Expert Review of Neurotherapeutics

Parkin mediates the degradation-independent ubiquitination of Hsp70

(2008) Darren J. Moore et al.   JOURNAL OF NEUROCHEMISTRY

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease

(2008) Alim Louis Benabid et al.   LANCET NEUROLOGY

Metabolomic analysis of urine and serum in Parkinson’s disease

(2008) Andrew W. Michell et al.   Metabolomics

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

A controlled trial of antidepressants in patients with Parkinson disease and depression

(2008) M. Menza et al.   NEUROLOGY

Statin use and the risk of Parkinson disease

(2008) A. D. Wahner et al.   NEUROLOGY

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

(2008) J. L. Eberling et al.   NEUROLOGY

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Critical issues of clinical human embryonic stem cell therapy for brain repair

(2008) Jia-Yi Li et al.   TRENDS IN NEUROSCIENCES

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain

Disease-modifying drugs and Parkinson's disease

(2007) Hervé Allain et al.   PROGRESS IN NEUROBIOLOGY