Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling

(2021) Juliane C Campos et al.   EMBO REPORTS

Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans

(2020) Ai Ito et al.   BIOGERONTOLOGY

Global transcriptional regulation of innate immunity by ATF-7 in C. elegans

(2019) Marissa Fletcher et al.   PLoS Genetics

HSB-1 Inhibition and HSF-1 Overexpression Trigger Overlapping Transcriptional Changes to Promote Longevity in Caenorhabditis elegans

(2019) Surojit Sural et al.   G3-Genes Genomes Genetics

Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity

(2019) Ziyun Wu et al.   Cell Metabolism

Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes

(2019) Kai Mao et al.   Cell Metabolism

HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes

(2019) Kovács et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

(2018) Megan M. Senchuk et al.   PLoS Genetics

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans

(2017) Dylan J. Dues et al.   FREE RADICAL BIOLOGY AND MEDICINE

The ModERN Resource: Genome-Wide Binding Profiles for Hundreds ofDrosophilaandCaenorhabditis elegansTranscription Factors

(2017) Michelle M. Kudron et al.   GENETICS

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

(2017) Jason F. Cooper et al.   Scientific Reports

The ModERN Resource: Genome-Wide Binding Profiles for Hundreds ofDrosophilaandCaenorhabditis elegansTranscription Factors

(2017) Michelle M. Kudron et al.   GENETICS

Characterization of the direct targets of FOXO transcription factors throughout evolution

(2016) Ashley E. Webb et al.   AGING CELL

Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways

(2016) Dylan J. Dues et al.   Aging-US

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response

(2016) Jian Li et al.   GENES & DEVELOPMENT

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Oxidative stress is increased in C. elegans models of Huntington’s disease but does not contribute to polyglutamine toxicity phenotypes

(2016) Emily Machiela et al.   NEUROBIOLOGY OF DISEASE

Roles for ROS and hydrogen sulfide in the longevity response to germline loss inCaenorhabditis elegans

(2016) Yuehua Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans

(2016) Salvador Peña et al.   PLoS One

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

(2015) Neeraj Kumar et al.   Oncotarget

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation?

(2014) Christopher F. Bennett et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial stress: Balancing friend and foe

(2014) Eva Diana Runkel et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

(2014) Collin Y. Ewald et al.   NATURE

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity

(2013) Ronald G. Tepper et al.   CELL

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway

(2013) M. Rauthan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Characterization of the Caenorhabditis elegans Mitochondrial Thioredoxin System Uncovers an Unexpected Protective Role of Thioredoxin Reductase 2 in β-Amyloid Peptide Toxicity

(2012) Briseida Cacho-Valadez et al.   ANTIOXIDANTS & REDOX SIGNALING

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1

(2011) Jeremy Michael Van Raamsdonk et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans

(2010) W. Niu et al.   GENOME RESEARCH

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans

(2007) Nate W. Kahn et al.   BIOCHEMICAL JOURNAL