Mitochondria in Pathological Cardiac Hypertrophy Research and Therapy

Aerobic exercise ameliorates cardiac hypertrophy by regulating mitochondrial quality control and endoplasmic reticulum stress through M 2 AChR

(2021) Mei Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nlrp3 Deficiency Alleviates Angiotensin II-Induced Cardiomyopathy by Inhibiting Mitochondrial Dysfunction

(2021) Yu Chen et al.   Oxidative Medicine and Cellular Longevity

Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy

(2021) Rongjun Zou et al.   Oxidative Medicine and Cellular Longevity

FABP5 Deficiency Impairs Mitochondrial Function and Aggravates Pathological Cardiac Remodeling and Dysfunction

(2021) Shanquan Gao et al.   Cardiovascular Toxicology

Mitochondrial disruption is involved in the effect of NFATc4 on aggravating cardiomyocyte hypertrophy

(2021) Xueping Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Allyl Methyl Sulfide Preserved Pressure Overload-Induced Heart Failure Via Modulation of Mitochondrial Function

(2021) Soheb Anwar Mohammed et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling

(2021) Guoqi Li et al.   CARDIOVASCULAR RESEARCH

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis

(2021) Thirupura S. Shankar et al.   Nature Communications

Targeting mitochondrial reactive oxygen species-mediated oxidative stress attenuates nicotine-induced cardiac remodeling and dysfunction

(2021) Anand Ramalingam et al.   Scientific Reports

Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction

(2021) Xin Luo et al.   Scientific Reports

Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR-α Signaling Pathway Improving Energy Metabolism

(2021) Xiaoying Zhang et al.   Frontiers in Pharmacology

Quantitative Proteomics Reveal That Metabolic Improvement Contributes to the Cardioprotective Effect of T89 on Isoproterenol-Induced Cardiac Injury

(2021) Xiao-Hong Wei et al.   Frontiers in Physiology

Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

(2021) Dongqi An et al.   Redox Biology

SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity

(2020) Xiaojun Feng et al.   Aging-US

Mitochondrial behaviour, morphology, and animal performance

(2020) Kyle B. Heine et al.   BIOLOGICAL REVIEWS

A Machine Learning-driven Study Indicates Emodin Improves Cardiac Hypertrophy by Modulation of Mitochondrial SIRT3 Signaling

(2020) Jian Gao et al.   PHARMACOLOGICAL RESEARCH

Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes

(2020) Carolina Conejeros et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

(2020) Wenjia Li et al.   Cell Death & Disease

Mitochondria in acute myocardial infarction and cardioprotection

(2020) Chrishan J.A. Ramachandra et al.   EBioMedicine

Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes

(2020) Bing-yan Liu et al.   ACTA PHARMACOLOGICA SINICA

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

(2020) Elizabeth D. Luczak et al.   Nature Communications

Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure

(2020) Miyesaier Abudureyimu et al.   Frontiers in Physiology

Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway

(2020) Yi Yang et al.   Aging-US

Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy

(2020) Maya Dia et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondria as a therapeutic target for cardiac ischemia‑reperfusion injury (Review)

(2020) Wenwen Marin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy

(2019) Dachun Xu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Mitochondrial Dysfunction in Atherosclerosis

(2019) Wenxi Peng et al.   DNA AND CELL BIOLOGY

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

(2019) Aline Maria Brito Lucas et al.   Current Molecular Pharmacology

TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction

(2019) Tianyi Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction

(2019) Yangpo Cao et al.   CIRCULATION RESEARCH

Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy

(2019) Run-Qing Xue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

PTENα Regulates Mitophagy and Maintains Mitochondrial Quality Control

(2018) Yuxin Yin et al.   Autophagy

miR-376b-3p attenuates mitochondrial fission and cardiac hypertrophy by targeting mitochondrial fission factor

(2018) Yong Le Sun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats

(2018) Prottoy Hasan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

(2018) Georges N. Kanaan et al.   Redox Biology

Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway

(2018) Man Xu et al.   CARDIOVASCULAR RESEARCH

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

(2018) Anna Picca et al.   Nature Reviews Cardiology

Deficiency of PKD2L1 (TRPP3) Exacerbates Pathological Cardiac Hypertrophy by Augmenting NCX1-Mediated Mitochondrial Calcium Overload

(2018) Zongshi Lu et al.   Cell Reports

Overexpression of miR-142-3p improves mitochondrial function in cardiac hypertrophy

(2018) Bei-lei Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure

(2018) Oliver J Müller et al.   CARDIOVASCULAR RESEARCH

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

(2018) Seitaro Nomura et al.   Nature Communications

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

(2017) Kathleen A. Hershberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy

(2017) Kai Tang et al.   Journal of the American Heart Association

Mitochondrial fission and fusion

(2016) H. Lee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure

(2016) Rob C.I. Wüst et al.   CARDIOVASCULAR RESEARCH

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Mitochondrial autophagy in cardiomyopathy

(2016) Mingming Tong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity

(2016) Yu-Xuan Luo et al.   EUROPEAN HEART JOURNAL

Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes

(2016) Wardit Tigchelaar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

miR-106a promotes cardiac hypertrophy by targeting mitofusin 2

(2016) Xiaoxiang Guan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy

(2016) Shin Ito et al.   Journal of the American Heart Association

Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis

(2015) J Zhao et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

(2015) Moshi Song et al.   Cell Metabolism

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

(2015) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice

(2015) Hyeong Jun Ku et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial biogenesis and dynamics in the developing and diseased heart

(2015) Gerald W. Dorn et al.   GENES & DEVELOPMENT

High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss

(2015) Heng Zeng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The war against heart failure: the Lancet lecture

(2015) Eugene Braunwald   LANCET

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

(2013) Liyan Zhang et al.   Circulation-Heart Failure

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy

(2011) E. D. Abel et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

(2011) Chris McDermott-Roe et al.   NATURE

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH