Targeting Oxidative Stress, NLRP3 Inflammasome, and Autophagy by Fraxetin to Combat Doxorubicin-Induced Cardiotoxicity

Shengxian decoction decreases doxorubicin‑induced cardiac apoptosis by regulating the TREM1/NF‑κB signaling pathway

(2021) Lei Yao et al.   Molecular Medicine Reports

Coumarin Derivatives in Inflammatory Bowel Disease

(2021) Luiz C. Di Stasi   MOLECULES

Activation of Nrf2 by miR-152 Inhibits Doxorubicin-Induced Cardiotoxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

(2021) Wen-Bin Zhang et al.   Oxidative Medicine and Cellular Longevity

Regulated cell death pathways in doxorubicin-induced cardiotoxicity

(2021) Effimia Christidi et al.   Cell Death & Disease

The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation

(2021) Yangyang Guo et al.   Aging-US

Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction via regulating Nrf2/Sirt3 signaling pathway

(2021) Jiwei Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro

(2021) Chun Wang et al.   TOXICOLOGY

Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice

(2021) Zachary R. Wakefield et al.   Oncotarget

In Vitro and In Vivo Antifibrotic Effects of Fraxetin on Renal Interstitial Fibrosis via the ERK Signaling Pathway

(2021) Yi-Hsien Hsieh et al.   Toxins

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats

(2021) Seenipandi Arunachalam et al.   Antioxidants

Isofraxidin Alleviates Myocardial Infarction Through NLRP3 Inflammasome Inhibition

(2020) Guofan Chen et al.   INFLAMMATION

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1

(2020) Zhenzhu Sun et al.   BIOCHEMICAL PHARMACOLOGY

Review of Intraperitoneal Injection of Sodium Pentobarbital as a Method of Euthanasia in Laboratory Rodents

(2020) Colin A Laferriere et al.   Journal of the American Association for Laboratory Animal Science

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

(2020) Emad H. M. Hassanein et al.   Oxidative Medicine and Cellular Longevity

Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1/AKT/Bcl-2 signalling pathway

(2020) YanDong Zhang et al.   PeerJ

The Role of NLRP3 Inflammasome Activation in the Epithelial to Mesenchymal Transition Process During the Fibrosis

(2020) Amani Abraheem Alsadiq Alyaseer et al.   Frontiers in Immunology

Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity

(2020) Shanshan Wei et al.   Cardiovascular Toxicology

The beneficial effects of reducing NLRP3 inflammasome activation in the cardiotoxicity and the anti-cancer effects of doxorubicin

(2020) Zaid H. Maayah et al.   ARCHIVES OF TOXICOLOGY

Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling

(2020) Xiaoli Cheng et al.   Biomed Research International

A mini-review on ion fluxes that regulate NLRP3 inflammasome activation

(2020) Chenguang Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways

(2019) Bin Wu et al.   Pharmacological Reports

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The true colors of autophagy in doxorubicin‑induced cardiotoxicity (Review)

(2019) Bin Xiao et al.   Oncology Letters

Involvement of neurotrophic signaling in doxorubicin‑induced cardiotoxicity

(2019) Dehua Liao et al.   Experimental and Therapeutic Medicine

Targeting the proinflammatory cytokines, oxidative stress, apoptosis and TGF-β1/STAT-3 signaling by irbesartan to ameliorate doxorubicin-induced hepatotoxicity

(2018) Ahmed M. Kabel et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells

(2018) Judit Erdei et al.   Oxidative Medicine and Cellular Longevity

Scopoletin 8-Hydroxylase-Mediated Fraxetin Production is Crucial for Iron Mobilization

(2018) Huei-Hsuan Tsai et al.   PLANT PHYSIOLOGY

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

(2018) Jessica Marinello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways

(2018) Dina S. El-Agamy et al.   Cancer Management and Research

Fraxetin and ethyl acetate extract from Lawsonia inermis L. ameliorate oxidative stress in P. berghei infected mice by augmenting antioxidant defence system

(2017) Dhananjay Kumar Singh et al.   PHYTOMEDICINE

Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

(2015) Iveta Najmanova et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Effect of metformin and adriamycin on transplantable tumor model

(2015) Ahmed M. Kabel et al.   TISSUE & CELL

Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats

(2015) Mustafa Argun et al.   Anatolian Journal of Cardiology

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

(2013) Raju Murali et al.   BIOCHIMIE

The Cardioprotective Role of Probucol Against Anthracycline and Trastuzumab-Mediated Cardiotoxicity

(2011) Jonathan R. Walker et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY