Bile Acid–Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in Mice

AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1

(2021) Meng Shi et al.   NATURE CELL BIOLOGY

Chronic Alcohol Consumption Increased Bile Acid Levels in Enterohepatic Circulation and Reduced Efficacy of Irinotecan

(2020) Xia Gong et al.   ALCOHOL AND ALCOHOLISM

Programmed cell death in alcohol-associated liver disease

(2020) Tatsunori Miyata et al.   Clinical and Molecular Hepatology

Effect of ethanol on lipid metabolism

(2019) Min You et al.   JOURNAL OF HEPATOLOGY

TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

(2019) Grégory Merlen et al.   GUT

FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury

(2019) Bo Kong et al.   DIGESTIVE AND LIVER DISEASE

Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice

(2019) Hong Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

How does your fat affect your liver when you drink?

(2019) Seonghwan Hwang et al.   JOURNAL OF CLINICAL INVESTIGATION

Bile-ology: from bench to bedside

(2019) Li-hua Jin et al.   Journal of Zhejiang University-SCIENCE B

Diagnosis and Treatment of Alcohol‐Related Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases

(2019) David W. Crabb et al.   HEPATOLOGY

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

(2018) Katharina Brandl et al.   JOURNAL OF HEPATOLOGY

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Dual role of the bile acid receptor Takeda G-protein-coupled receptor 5 for hepatic lipid metabolism in feast and famine

(2017) Dieter Häussinger et al.   HEPATOLOGY

Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity

(2017) Yi Lu et al.   MOLECULAR PHARMACOLOGY

Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations

(2017) Richard Parker et al.   Nature Reviews Gastroenterology & Hepatology

G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice

(2016) Ajay C. Donepudi et al.   HEPATOLOGY

Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

(2016) Lili Ding et al.   HEPATOLOGY

Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk

(2015) Phillipp Hartmann et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists

(2015) Donna D. Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice

(2015) Cuiqing Zhao et al.   JOURNAL OF LIPID RESEARCH

Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease

(2015) Tomonori Sugita et al.   Gastroenterology Research and Practice

Role of farnesoid X receptor and bile acids in alcoholic liver disease

(2015) Sharon Manley et al.   Acta Pharmaceutica Sinica B

Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

(2014) Sandra Jacinto et al.   Animal Cells and Systems

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

(2014) Guiyu Lou et al.   PLoS One

In Vivo Adeno-Associated Viral Vector-Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice

(2013) V. Jimenez et al.   DIABETES

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

(2013) Guoxiang Xie et al.   FASEB JOURNAL

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice

(2012) Wei Zhong et al.   AMERICAN JOURNAL OF PATHOLOGY

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Patented TGR5 modulators: a review (2006 – present)

(2012) Antimo Gioiello et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

(2011) Becky M. Sebastian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic control ofde novolipogenesis: role in diet-induced obesity

(2010) Maggie S. Strable et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism