Targeting integrin αvβ3 with indomethacin inhibits patient‐derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma

Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo

(2021) Xuechao Jia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3

(2021) Yamei Hu et al.   ONCOGENE

TAZ target gene ITGAV regulates invasion and feeds back positively on YAP and TAZ in liver cancer cells

(2020) Sofia M.E. Weiler et al.   CANCER LETTERS

Anti-tumor effects of anti-PD-1 antibody, pembrolizumab, in humanized NSG PDX mice xenografted with dedifferentiated liposarcoma

(2020) Bongkum Choi et al.   CANCER LETTERS

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1

(2019) Gaoxiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Ilex hainanensis Merr targets ITGAV to suppress the proliferation and metastasis of osteosarcoma cells

(2019) Yi Pei et al.   OncoTargets and Therapy

Results of a Phase 1/2 Trial of Chemoradiotherapy With Simultaneous Integrated Boost of Radiotherapy Dose in Unresectable Locally Advanced Esophageal Cancer

(2019) Dawei Chen et al.   JAMA Oncology

A bispecific antibody targeting the αv and α5β1 integrins induces integrin degradation in prostate cancer cells and is superior to monospecific antibodies

(2019) Raghav Joshi et al.   MOLECULAR CANCER RESEARCH

Controlling Immunity and Inflammation through Integrin-Dependent Regulation of TGF-β

(2019) Martijn Nolte et al.   TRENDS IN CELL BIOLOGY

Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions

(2018) Meng Wang et al.   Annals of the New York Academy of Sciences

Epidemiology of Esophageal Squamous Cell Carcinoma

(2018) Christian C. Abnet et al.   GASTROENTEROLOGY

Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients

(2018) De-Chen Lin et al.   GASTROENTEROLOGY

14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling

(2018) Jing Luo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy

(2018) Zhen Fan et al.   Nature Communications

Treatment for unresectable or metastatic oesophageal cancer: current evidence and trends

(2017) Peter S. N. van Rossum et al.   Nature Reviews Gastroenterology & Hepatology

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis

(2016) C. Coyle et al.   ANNALS OF ONCOLOGY

The E3 ubiquitin ligase c-Cbl mediates integrin β1 ubiquitination during dilated cardiomyopathy

(2016) Nan Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential Effect on Bone Lesions of Targeting Integrins: Randomized Phase II Trial of Abituzumab in Patients with Metastatic Castration-Resistant Prostate Cancer

(2016) M. Hussain et al.   CLINICAL CANCER RESEARCH

CEP55 overexpression predicts poor prognosis in patients with locally advanced esophageal squamous cell carcinoma

(2016) Wenpeng Jiang et al.   Oncology Letters

Population-wide Impact of Long-term Use of Aspirin and the Risk for Cancer

(2016) Yin Cao et al.   JAMA Oncology

Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3

(2015) SIDA QIN et al.   Molecular Medicine Reports

Correlation between the expression of integrins in prostate cancer and clinical outcome in 1284 patients

(2014) Katharina Heß et al.   Annals of Diagnostic Pathology

Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction

(2014) Vincent Sarrazy et al.   CARDIOVASCULAR RESEARCH

Emerging therapies targeting the ubiquitin proteasome system in cancer

(2014) Nathaniel M. Weathington et al.   JOURNAL OF CLINICAL INVESTIGATION

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

(2013) Jeong-Hwan Yoon et al.   EMBO Molecular Medicine

αv-Integrin isoform expression in primary human tumors and brain metastases

(2013) Alexander Vogetseder et al.   INTERNATIONAL JOURNAL OF CANCER

Oesophageal carcinoma

(2013) Arjun Pennathur et al.   LANCET

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator

(2013) Robert A Terkeltaub et al.   ARTHRITIS RESEARCH & THERAPY

A randomized, double-blind, multicenter, phase 2 study of a human monoclonal antibody to human αν integrins (intetumumab) in combination with docetaxel and prednisone for the first-line treatment of patients with metastatic castration-resistant prostate cancer

(2012) A. Heidenreich et al.   ANNALS OF ONCOLOGY

The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells

(2012) Claudia Brunelli et al.   BIOCHEMICAL JOURNAL

Integrin αv Expression Is Required for the Acquisition of a Metastatic Stem/Progenitor Cell Phenotype in Human Prostate Cancer

(2011) Christel van den Hoogen et al.   AMERICAN JOURNAL OF PATHOLOGY

COX inhibitors directly alter gene expression: role in cancer prevention?

(2011) Xingya Wang et al.   CANCER AND METASTASIS REVIEWS

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

(2011) Kendra Garrison et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Androgen Receptor Induces Integrin  6 1 to Promote Prostate Tumor Cell Survival via NF- B and Bcl-xL Independently of PI3K Signaling

(2011) L. E. Lamb et al.   CANCER RESEARCH

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine

(2011) Moses K. Donkor et al.   IMMUNITY

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor–Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface

(2010) Kalyan C. Nannuru et al.   CANCER RESEARCH

Perioperative management of esophageal cancer

(2010) Alicia Okines et al.   Nature Reviews Clinical Oncology

Enhanced drug targeting by attachment of an anti αv integrin antibody to doxorubicin loaded human serum albumin nanoparticles

(2009) Sylvia Wagner et al.   BIOMATERIALS

Progressive Multifocal Leukoencephalopathy after Natalizumab Monotherapy

(2009) Hans Lindå et al.   NEW ENGLAND JOURNAL OF MEDICINE