METTL1 promotes hepatocarcinogenesis via m 7 G tRNA modification‐dependent translation control

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N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

(2021) Esteban A. Orellana et al.   MOLECULAR CELL

METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression

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Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA

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RNA modifications regulating cell fate in cancer

(2019) Sylvain Delaunay et al.   NATURE CELL BIOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Gene Expression by N-methyladenosine in Cancer

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METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN

(2019) Qiu-Hong Tian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

(2019) Yunhao Chen et al.   Molecular Cancer

TrmB, a tRNA m7G46 methyltransferase, plays a role in hydrogen peroxide resistance and positively modulates the translation of katA and katB mRNAs in Pseudomonas aeruginosa

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Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing

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Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq

(2019) Shuibin Lin et al.   Nature Protocols

Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis

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Modifications and functional genomics of human transfer RNA

(2018) Tao Pan   CELL RESEARCH

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Mettl1/Wdr4-Mediated m 7 G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation

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Mutations in WDR4 as a new cause of Galloway-Mowat syndrome

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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The RNA modification landscape in human disease

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ALKBH1-Mediated tRNA Demethylation Regulates Translation

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The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

The role of hepatic resection in the treatment of hepatocellular cancer

(2015) Sasan Roayaie et al.   HEPATOLOGY

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry

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tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

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A High-Throughput Quantitative Approach Reveals More Small RNA Modifications in Mouse Liver and Their Correlation with Diabetes

(2013) Menghong Yan et al.   ANALYTICAL CHEMISTRY

Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific

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Radiofrequency Ablation of Hepatocellular Carcinoma as First-Line Treatment: Long-term Results and Prognostic Factors in 162 Patients with Cirrhosis

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Cancer Epigenetics: From Mechanism to Therapy

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AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

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