Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy

In situ vaccination and gene-mediated PD-L1 blockade for enhanced tumor immunotherapy

(2021) Yingying Hu et al.   CHINESE CHEMICAL LETTERS

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

(2020) Geoffrey M. Lynn et al.   NATURE BIOTECHNOLOGY

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response

(2020) Xiang Yu et al.   Nature Communications

Poly(l-glutamic acid)-Based Zwitterionic Polymer in a Charge Conversional Shielding System for Gene Therapy of Malignant Tumors

(2020) Jie Chen et al.   ACS Applied Materials & Interfaces

Effects of Branching Strategy on the Gene Transfection of Highly Branched Poly(β-amino ester)s

(2020) Yao Wang et al.   CHINESE JOURNAL OF POLYMER SCIENCE

A triple-combination nanotechnology platform based on multifunctional RNA hydrogel for lung cancer therapy

(2020) Junwei Li et al.   Science China-Chemistry

Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

(2020) Xiaobo Xi et al.   Science Advances

Clinical Challenges of Immune Checkpoint Inhibitors

(2020) Maria de Miguel et al.   CANCER CELL

“Building-block crosslinking” micelles for enhancing cellular transfection of biocompatible polycations

(2020) Pengkai Wu et al.   Science China-Materials

Highly Enhanced Antitumor Immunity by a Three-Barreled Strategy of the l-Arginine-Promoted Nanovaccine and Gene-Mediated PD-L1 Blockade

(2020) Yingying Hu et al.   ACS Applied Materials & Interfaces

Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger

(2020) Yingying Hu et al.   BIOMATERIALS

An immune cocktail therapy to realize multiple boosting of the cancer-immunity cycle by combination of drug/gene delivery nanoparticles

(2020) Jiayan Wu et al.   Science Advances

Functionalized multifunctional nanovaccine for targeting dendritic cells and modulation of immune response

(2020) Nesma El-Sayed et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Recent advances in polymeric biomaterials-based gene delivery for cartilage repair

(2020) Ran Yang et al.   Bioactive Materials

Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

(2020) Ye Liang et al.   Bioactive Materials

Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy

(2019) Linhua Zhang et al.   NANO LETTERS

Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy

(2019) Jun Xu et al.   BIOMATERIALS

Mannosylated PEGylated-Polyethyleneimine as Efficient CpG Oligodeoxynucleotide Carriers for Efficient Dendritic Cell Targeting Delivery and Activation

(2019) Junfeng Liu et al.   Journal of Biomedical Nanotechnology

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

(2019) Qian Chen et al.   NANO LETTERS

Nanoenabled Reversal of IDO1-Mediated Immunosuppression Synergizes with Immunogenic Chemotherapy for Improved Cancer Therapy

(2019) Hua Huang et al.   NANO LETTERS

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

(2019) João Conniot et al.   Nature Nanotechnology

Peptide-Based Vaccines: Current Progress and Future Challenges

(2019) Ryan J. Malonis et al.   CHEMICAL REVIEWS

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

(2018) Xudong Zhang et al.   ADVANCED MATERIALS

Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase

(2018) Xiuwen Guan et al.   BIOMATERIALS

Molecular Strings Significantly Improved the Gene Transfection Efficiency of Polycations

(2018) Huapan Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polycations for Gene Delivery: Dilemmas and Solutions

(2018) Jie Chen et al.   BIOCONJUGATE CHEMISTRY

Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy

(2016) Yuan Qian et al.   BIOMATERIALS

Production and clinical development of nanoparticles for gene delivery

(2016) Jie Chen et al.   Molecular Therapy-Methods & Clinical Development

pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response

(2015) Qi Liu et al.   ACS Nano

Immune responses to vaccines involving a combined antigen–nanoparticle mixture and nanoparticle-encapsulated antigen formulation

(2014) Weifeng Zhang et al.   BIOMATERIALS

An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

(2013) Christopher B Fox et al.   Expert Review of Vaccines

Dendritic cell targeted liposomes–protamine–DNA complexes mediated by synthetic mannosylated cholestrol as a potential carrier for DNA vaccine

(2013) Pan Li et al.   NANOTECHNOLOGY

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

(2012) Evan A. Scott et al.   BIOMATERIALS

Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization

(2011) Satwinder Kaur Singh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

(2010) Suzanne Foster et al.   BIOCONJUGATE CHEMISTRY

Gene therapy progress and prospects: synthetic polymer-based systems

(2008) D Schaffert et al.   GENE THERAPY