Article
Infectious Diseases
Chris Kenyon
Summary: The study found a significant association between macrolide use in food-producing animals and pneumococcal macrolide resistance, indicating the need for further research to verify this hypothesis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Alexandra Chiaverini, Alessandra Cornacchia, Gabriella Centorotola, Elga Ersilia Tieri, Nadia Sulli, Ilaria Del Matto, Giorgio Iannitto, Domenico Petrone, Antonio Petrini, Francesco Pomilio
Summary: This study investigates the occurrence of Klebsiella pneumoniae in wildlife and its antimicrobial resistance. The results show the presence of resistant strains in wild animals, indicating a link between humans, domestic animals, and wildlife. This highlights the lack of knowledge about this ecological context and underestimation of potential health risks.
Review
Veterinary Sciences
Alice C. Tompson, Ana L. P. Mateus, Dave C. Brodbelt, Clare I. R. Chandler
Summary: The review found that antibiotics are frequently used in companion animal care and qualitative research methods contribute to a deeper understanding of the context of antibiotic use. Future research and policy efforts should consider the societal structures and networks that impact companion animal antibiotic use, moving beyond individual choices.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Piotr Serwacki, Mateusz Gajda, Wioletta Swiatek-Kwapniewska, Marta Walaszek, Karolina Nowak, Jadwiga Wojkowska-Mach
Summary: The study aimed to assess the use of fluoroquinolone (FQ) in treatment by analyzing FQ consumption and resistance levels of selected pathogens in EU/EEA countries and Poland between 2016 and 2021. Data from ECDC surveillance systems were used to describe pathogen resistance, and the ESAC-Net project was used to determine FQ consumption. The study found that FQ consumption decreased in most EU/EEA countries, but Poland still had high usage. It recommends withdrawing FQ from empirical treatment in Poland and countries with high FQ-resistant microorganisms.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olivia M. Gruenzweil, Lauren Palmer, Adriana Cabal, Michael P. Szostak, Werner Ruppitsch, Christian Kornschober, Maciej Korus, Dusan Misic, Tanja Bernreiter-Hofer, Anna D. J. Korath, Andrea T. Fessler, Franz Allerberger, Stefan Schwarz, Joachim Spergser, Elke Mueller, Sascha D. Braun, Stefan Monecke, Ralf Ehricht, Chris Walzer, Hrvoje Smodlaka, Igor Loncaric
Summary: The study aimed to investigate the presence of ESBL- and AmpC-producing Enterobacterales, as well as Salmonella, in marine mammals. Results revealed a high prevalence of multidrug-resistant bacteria and pandemic high-risk clones, indicating anthropogenic antimicrobial pollution in these animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Rapacka-Zdonczyk, Agata Wozniak, Beata Kruszewska, Krzysztof Waleron, Mariusz Grinholc
Summary: The study aimed to demonstrate the potential tolerance development in Gram-negative bacteria during antimicrobial blue light (aBL) treatment. Results showed that representative Gram-negative bacteria may develop tolerance to aBL, and the observed adaptation was a stable feature. Assays involving deficient mutants revealed possible mechanisms for aBL tolerance development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Yann Mouanga Ndzime, Richard Onanga, Roland Fabrice Kassa Kassa, Michelle Bignoumba, Pierre Philippe Mbehang Nguema, Amahani Gafou, Romeo Wenceslas Lendamba, Kelly Mbombe Moghoa, Cyrille Bisseye
Summary: Urinary tract infections are a major cause of consultation worldwide, with E. coli and K. pneumoniae being the main uropathogenic strains. This study in Franceville found a high prevalence of UTIs caused by these bacteria, with high levels of antibiotic resistance, emphasizing the need for appropriate local antibiotic use.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Kasim Allel, Anne Peters, Jose Conejeros, Jose R. W. Martinez, Maria Spencer-Sandino, Roberto Riquelme-Neira, Lina Rivas, Pamela Rojas, Cristian Orellana Chea, Patricia Garcia, Rafael Araos, Olivia McGovern, Twisha S. Patel, Cesar A. Arias, Fernanda C. Lessa, Eduardo A. Undurraga, Jose M. Munita
Summary: The increased usage of carbapenems and broad-spectrum β-lactams during the COVID-19 pandemic was associated with a higher prevalence of carbapenemase-producing Klebsiella pneumoniae in a public hospital in Chile. We observed emergence and spread of bla(NDM) ST45 during the pandemic. These data are critical to inform national policies and clinical care.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Agriculture, Dairy & Animal Science
Biel Garcias, Laia Aguirre, Chiara Seminati, Nerea Reyes, Alberto Allepuz, Elena Obon, Rafael A. Molina-Lopez, Laila Darwich
Summary: This study identified a high prevalence of ESBL resistant enterobacteria and AMR genes in wild European hedgehogs in Catalonia, highlighting their potential role as sentinels for AMR environmental pollution, particularly in densely populated areas. The results suggest a strong correlation between human activity and transmission of AMR genes to wildlife, emphasizing the need for One Health approach in tackling AMR issues.
Article
Infectious Diseases
Siwei Guo, Xin Li, You Li, Huan Tong, Minji Wei, Bingqian Yan, Miaomei Tian, Bing Xu, Jing Shao
Summary: Sitafloxacin fumarate injection is an alternative therapeutic agent for the treatment of UTIs caused by MDR isolates. The study shows that Sitafloxacin has lower MICs compared to levofloxacin and has a high probability of achieving target attainment in common complicated urinary tract infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Environmental Sciences
Prateek Jindal, Jasbir Bedi, Randhir Singh, Rabinder Aulakh, Jatinder Gill
Summary: The study found that commensal E. coli and Klebsiella harbor antimicrobial drug resistance genes in farm environments, which may impact human populations and the environment, with untreated animal waste being considered a significant source of resistant bacteria leading to environmental pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Sheeba S. Manoharan-Basil, Natalia Gonzalez, Chris Kenyon
Summary: This study found a positive correlation between the prevalence of meningococcal reduced susceptibility to cefotaxime and ciprofloxacin and the consumption of cephalosporins and quinolones. This finding emphasizes the importance of strengthening antimicrobial stewardship programs.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Alice Elena Ghenea, Ovidiu Mircea Zlatian, Oana Mariana Cristea, Anca Ungureanu, Radu Razvan Mititelu, Andrei Theodor Balasoiu, Corina Maria Vasile, Alex-Ioan Salan, Daniel Iliuta, Mihaela Popescu, Anca-Loredana Udristoiu, Maria Balasoiu
Summary: CTX-M β-lactamases have become the most prevalent ESBLs in Enterobacteriaceae. This study identified the prevalence of bla(CTX-M-15), bla(SHV-1), and bla(TEM-1) encoding β-lactamases in Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) strains in a Romanian hospital's ICU. The findings highlight the importance of reducing antibiotic use and improving resistance surveillance to guide local antibiotic therapy.
Article
Pharmacology & Pharmacy
Reem E. Alarfaj, Manal M. Alkhulaifi, Ahmed J. Al-Fahad, Shokran Aljihani, Alaa Eldeen B. Yassin, Majed F. Alghoribi, Majed A. Halwani
Summary: This study tested the antibacterial activity and biofilm reduction capability of liposome formulations encapsulating tobramycin and Tobramycin-N-acetylcysteine against tobramycin-resistant strains of E. coli, K. pneumoniae and A. baumannii. The results showed that the TNL formulation exhibited the best antibacterial effect against A. baumannii, while both TL and TNL formulations reduced biofilm formation in E. coli and K. pneumoniae.
Article
Biochemistry & Molecular Biology
Cassandra L. Wouters, Neda Heydarian, Jennifer Pusavat, Hannah Panlilio, Anh K. Lam, Erika L. Moen, Robert E. Brennan, Charles V. Rice
Summary: This study focuses on using branched polyethylenimine (BPEI) modified with polyethylene glycol (PEG) to target virulence from Gram-negative bacterial pathogens. Results show that the beta-lactam antibiotic oxacillin can be potentiated by 600 Da BPEI to kill some Escherichia coli and Klebsiella pneumoniae. Modification of 600 Da BPEI with PEG increases drug safety and improves activity. The ability to use oxacillin against Gram-negative pathogens expands effective treatment options and simplifies complicated treatment regimens.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Editorial Material
Immunology
Robert L. Colebunders, Chris Kenyon
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Irith De Baetselier, Bea Vuylsteke, Thijs Reyniers, Hilde Smet, Dorien Van den Bossche, Chris Kenyon, Tania Crucitti
Summary: The study found that MSM who were recurrently infected with STIs were more likely to have Mycoplasma genitalium infections and were more resistant to macrolides and fluoroquinolones. These individuals play a crucial role in the emergence of antimicrobial resistance in M. genitalium.
INTERNATIONAL JOURNAL OF STD & AIDS
(2022)
Article
Immunology
Chris Kenyon, Thibaut Vanbaelen, Christophe Van Dijck
Summary: Many countries are facing the dual epidemics of increasing STI incidence and antimicrobial resistance. Intensifying STI screening is suggested, but it may not have a significant impact on STI prevalence while having a deleterious effect on antimicrobial resistance. A multi-level, socio-ecological framework is proposed to better understand the determinants of STI prevalence and AMR spread.
INTERNATIONAL JOURNAL OF STD & AIDS
(2022)
Article
Immunology
Christophe Van Dijck, Irith De Baetselier, Vicky Cuylaerts, Jozefien Buyze, Jolein Laumen, Bea Vuylsteke, Chris Kenyon
Summary: The study found a significant association between coinfection with Mycoplasma genitalium and higher gonococcal bacterial load. This suggests that Mycoplasma genitalium may play a role as a cofactor in gonococcal transmission.
INTERNATIONAL JOURNAL OF STD & AIDS
(2022)
Article
Multidisciplinary Sciences
Jolein Gyonne Elise Laumen, Christophe Van Dijck, Said Abdellati, Irith De Baetselier, Gabriela Serrano, Sheeba Santhini Manoharan-Basil, Emmanuel Bottieau, Delphine Martiny, Chris Kenyon
Summary: Non-pathogenic Neisseria are a reservoir of antimicrobial resistance genes for pathogenic Neisseria meningitidis and Neisseria gonorrhoeae. Men who have sex with men (MSM) are at risk of co-colonization with resistant non-pathogenic and pathogenic Neisseria. Our study found that non-pathogenic Neisseria among MSM show lower susceptibility to azithromycin and ciprofloxacin compared to a general population, while susceptibility to ceftriaxone did not differ significantly. Antimicrobial exposure did not have a significant impact on susceptibility of non-pathogenic Neisseria in MSM.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Jolein Gyonne Elise Laumen, Said Abdellati, Christophe Van Dijck, Delphine Martiny, Irith De Baetselier, Sheeba Santhini Manoharan-Basil, Dorien van den Bossche, Chris Kenyon
Summary: This article explores the feasibility of using oral rinse-and-gargle samples and selective media to monitor antimicrobial resistance in commensal oropharyngeal Neisseria. The pilot study shows that the diversity and number of Neisseria species isolated from rinse samples were similar to those from swabs. The proportion of Neisseria colonies with decreased susceptibility to azithromycin was also comparable between the two sample types. This study provides encouraging data for using a simple protocol of oral rinse-and-gargle as a surveillance tool for monitoring antimicrobial susceptibility in commensal oropharyngeal Neisseria.
Article
Infectious Diseases
Chris Kenyon
Summary: The study found a significant association between macrolide use in food-producing animals and pneumococcal macrolide resistance, indicating the need for further research to verify this hypothesis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Chris Kenyon
Summary: This study found a positive correlation between the national median concentration of ciprofloxacin in rivers and fluoroquinolone resistance in Escherichia coli.
Letter
Infectious Diseases
Thibaut Vanbaelen, Thijs Reyniers, Anke Rotsaert, Bea Vuylsteke, Eric Florence, Chris Kenyon, Irith De Baetselier
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Infectious Diseases
Christophe Van Dijck, Chris Kenyon
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Infectious Diseases
Jef Vanhamel, Valeska Laisnez, Laurens Liesenborghs, Isabel Brosius, Nicole Berens-Riha, Thibaut Vanbaelen, Chris Kenyon, Koen Vercauteren, Marie Laga, Naima Hammami, Oriane Lambricht, Romain Mahieu, Amaryl Lecompte, Wim Vanden Berghe, Bea Vuylsteke
Summary: This study describes the initial phase of the monkeypox outbreak in Belgium and provides a detailed description of sexual behavior and transmission contexts. The results suggest that sexual contact and networks play a significant role in the transmission of monkeypox. Delayed detection of monkeypox infection may be attributed to the confusion of initial symptoms with other sexually transmitted infections or skin conditions, as well as low perception of risk.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Review
Infectious Diseases
Fabian Yuh Shiong Kong, Chris Kenyon, Magnus Unemo
Summary: Rates of STIs are increasing worldwide, and interventions using doxycycline post-exposure prophylaxis (PEP) have shown promise in reducing incidence. However, unanswered questions regarding long-term effects on microbiomes, antimicrobial resistance, and potential impact on STIs and other pathogens remain. In this review, seven areas of concern regarding the widespread use of doxycycline PEP are discussed.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Sheeba Santhini Manoharan-Basil, Margaux Balduck, Said Abdellati, Zina Gestels, Tessa de Block, Chris Kenyon
Summary: Antibiotic tolerance is associated with treatment failure, but the molecular mechanisms behind it are poorly understood. In a recent study, researchers induced tolerance to ceftriaxone in N. gonorrhoeae and identified mutations in four genes that may contribute to this tolerance. These findings provide insight into the development of antibiotic tolerance in bacteria.
Article
Immunology
Zina Gestels, Sheeba Santhini Manoharan-Basil, Chris Kenyon
Summary: Research suggests that the use of doxycycline as post-exposure prophylaxis in men who have sex with men may lead to cross-resistance to other antimicrobials, which should be considered in future studies.
INTERNATIONAL JOURNAL OF STD & AIDS
(2023)
Article
Infectious Diseases
Elvis Achondou Akomoneh, Zina Gestels, Said Abdellati, Katleen Vereecken, Koen Bartholomeeusen, Dorien van den Bossche, Chris Kenyon, Sheeba Santhini Manoharan-Basil
Summary: The growing threat of antimicrobial resistance has led the scientific community to search for new antimicrobial agents. In this study, a strain of Rothia dentocariosa with antimicrobial activity against pathogenic Neisseria species was investigated. The genomic DNA of the strain was sequenced and bioinformatic analysis was performed. Several biosynthetic gene clusters were identified, as well as peptides with potential antimicrobial activity. These findings have important implications for the development of antimicrobial products against multidrug-resistant N. gonorrhoeae.